Protein Alignment Sara and Zfyve9

DIOPT Version :9

• Sequence 1: NP_524729.2
• Gene: Sara / 44263
• FlyBaseID: FBgn0026369
• Length: 1343
• Species: Drosophila melanogaster
• Sequence 2: XP_006503049.1
• Gene: Zfyve9 / 230597
• MGIID: 2652838
• Length: 1431
• Species: Mus musculus
• Alignment Length: 1461
• Identity: 456/1461 - (31%)
• Similarity: 678/1461 - (46%)
• Gaps: 306/1461 - (20%)

  Fly    14 ELSIAADEQLSRNAAAAAAAGANPGRFLGDGASASISGVGAGAGVSGAAGVTPTPASGKSFVGVS 78
            |.::..|:.:.||.                ......|.|..|....|:....|...:    |.|.
Mouse   140 ENAVTEDQLIKRNY----------------NQDDQFSAVEVGEEKCGSLTCLPDEKN----VLVV 184

  Fly    79 QVFNSLDDYRENVKSLQVDAQ----------LPSYDWQTEAE-HEDDIHKFSEQASKNNGQTIVS 132
            .|.::.|.     ::||.|.|          :.|:....:.| .:.|...||...|...|.....
Mouse   185 AVMHNCDK-----RTLQSDLQDCNNYNSQSLMNSFSCSLDNETRQTDQFSFSMNGSTEKGINSEK 244

  Fly   133 SSESL---------------TTSSCSTFSSGPSPVSNGSHSEELATPPEDEKTSEVQVEPKEQDQ 182
            ..::|               .:|:.:|..|.||.:.:|   |.:...|.....:.:.|...:...
Mouse   245 QMDALNKPKPERDSVNHLCAASSNSATSISSPSQLKDG---ENVGRDPSTSTVTSLAVNSSQGMD 306

  Fly   183 QPEQVKHEDQHQDQAVPPPTQSKQTVEELAVGLSSISITASGTESQSLLPEEVTASSVLGQVL-- 245
            ....:|.:..:...            |:|: |::|.|.|..|..:        :.|...|::|
Mouse   307 GGPAIKQQGNYMPD------------EDLS-GMNSSSRTDLGISN--------SFSHSSGELLIK 350

  Fly   246 -----EELSEESSPS-----REPETEMTNGIDVPLANLPASVAEVPVPKEMEQPVQTEEEDVELP 300
                 |..:|:|.||     .:|:|...:|.|                 ..||............
Mouse   351 TEPAEERTAEDSLPSDLSLNLKPDTPALSGRD-----------------NCEQSSDCLGSSETRA 398

  Fly   301 QEQHPRRSQPLTFCST-MDEISDTELDSMLQEMDADDNQADDQQ-------MPDDEKSCSASPVT 357
            .|.....||...:..| ::|:||::::.. .:|....||.:|..       |.|.:.....:.:.
Mouse   399 DEDEGNDSQMTNWKLTKLNEMSDSQVNEE-NQMALQSNQPEDTNSGGECVGMADSDLDFKGTCMN 462

  Fly   358 EEESVRILSDEQETTSNDQMN-VDNFS-QASTVEFADLKQPESTPVTAMGEDVASSFS------- 413
            |.|.....:......:|...| .|::. |:..|.|.....|.........:::..|.|
Mouse   463 ESEGYDFSTVNDAPAANSLSNSCDSYGMQSPIVSFVPKTLPSKEDSVTEEKEIEESKSECYSNIY 527

  Fly   414 ---STESDSLSGRKLDGEVEVDREH------------------EDASLATDALETQEQRPQRPQT 457
               ..|:...||..|:....|.:::                  :.|:|.:.::.....||::|..
Mouse   528 EQRGNENAEGSGLLLNSTGNVMKKNYLHNFCSQIPSVLGQSSPKIANLQSISVPFGGARPKQPSN 592

  Fly   458 LNL-----------NGCQAESSTPSQDENPEIQQETL-QPTEVREGAAGVGVIPGED--DEESPI 508
            |.|           |...|.:...|:::|..:.:..| :.:.|...:|.:|.|...|  .|....
Mouse   593 LKLQIPKPLSDHLQNDLPANNGNNSKNKNDVLGKAKLGENSAVNACSATLGNISVTDTNGEHLET 657

  Fly   509 YEA-------------------------VGYSDPHANLGKVPPIWVPDNMAGQCMQCQQKFTMIK 548
            |||                         :....|...||:|.|:||||:.|..||:|:.:||..|
Mouse   658 YEAEISSRPCLALAPDSPDNDLRASQFGISARKPFTTLGEVAPVWVPDSQAPNCMKCEARFTFTK 722

  Fly   549 RRHHCRACGKVLCSVCCSQRFRLEFATEPESRVCVQCYMILSERQA--NGLNSESAPGSALPPTP 611
            |||||||||||.|:.|||.:.:|.:....|:||||.|:.:|...||  |.:::.|
Mouse   723 RRHHCRACGKVFCASCCSLKCKLLYMDRKEARVCVICHSVLMNAQAWENMMSASS---------- 777

  Fly   612 IRSPNPNNPMEYCSTIPPHRQVANSPGA---PPPSVIVPVGVLKKTDGSSSNSSSSDGQKGQRKR 673
             :|||||||.||||||||.:| |.:.||   |||:|:|||||||........         .|::
Mouse   778 -QSPNPNNPAEYCSTIPPLQQ-AQASGALSSPPPTVMVPVGVLKHPGTEVPQ---------PREQ 831

  Fly   674 KSVMFSDGIAPGSELASTMEQQWGESKHSRRGLSRSGS-GAGQKPPTPATEEP-PRSIDTSSTLG 736
            :.|.|:|||.|..|:|..       :|.:..|.|.:|: .....|..|....| |...|||
Mouse   832 RRVWFADGILPNGEVADA-------AKLTMNGTSSAGTLAVSHDPVKPVATSPLPTEADTS---- 885

  Fly   737 LVAQLFRGSIPPSAAAATLSATETSAGRSSSQSQAQTSPRRKAESSRNRKLPPNGDAQGCYLPPE 801
                ||.|||             |..|                        .|.|.|..  |.||
Mouse   886 ----LFSGSI-------------TQVG------------------------SPVGSAMN--LIPE 907

  Fly   802 ENGLPPICISSKEGGEVDYKVVRNDG--SLLDRLQN---ETLKFIIKNNFFVLVKIVNMSCCMNR 861
            : |||||.||:  |.:.||.|.....  |::.:|::   :.|.|::..|...:|||||.   :||
Mouse   908 D-GLPPILIST--GVKGDYAVEEKPSQISVMQQLEDGGPDPLVFVLNANLLSMVKIVNY---VNR 966

  Fly   862 WVLNFTTSGLHHMGSDELIILLEIKQPKQEEYVKGEVAIPKDLFQHLYEIYVEAEHAR-SGTHEL 925
            ....|||.|:|.:|..|::|||:.        :..|..:|||:|.|..::|.:|.... .|:...
Mouse   967 KCWCFTTKGMHAVGQSEIVILLQC--------LPDEKCLPKDIFNHFVQLYRDALAGNVVGSLGH 1023

  Fly   926 AFTSPRNANFLGSREHGGFIFIRPTYQCLQGVIVPDNPYLVGVLIHRHEVPWAKVLPLRLILRLG 990
            :|.|   .:||||:|||||:::..|||.||.:::|..|||.|:||.:.|.|||||.|:||:||||
Mouse  1024 SFFS---QSFLGSKEHGGFLYVTSTYQSLQDLVLPTPPYLFGILIQKWETPWAKVFPIRLLLRLG 1085

  Fly   991 AQYRYYPCPLISVRGRESVYGEIAQTIINFLVDFRNYSYSLPAIRGLYIHMEDRQTTVIIPKYRQ 1055
            |:||.|||||.|||.|:.::||...||:|.|.|||||.|:||.::||.:.||.|:|::.||..|.
Mouse  1086 AEYRLYPCPLFSVRFRKPLFGETGHTIMNLLADFRNYQYTLPVVQGLVVDMEVRKTSIKIPSNRY 1150

  Fly  1056 QDVIKAINNASDHILAFAGNFSKVADGHLVCMQNINDDRSEMYSYSTQAINIQGQPRKITGASFF 1120
            .:::||:|.:::|:||....|::.||.||||:|  |||.    :|.||||:|..||||:||||||
Mouse  1151 NEMMKAMNKSNEHVLAGGACFNEKADSHLVCVQ--NDDG----NYQTQAISIHNQPRKVTGASFF 1209

  Fly  1121 VLNEALKSSSGLSGKCSIVEDGLMVQIMPAKMEEVRQALRNQNDIDIVCGPIDATDDQSEIVSIK 1185
            |.:.|||||||...|.||||||:||||....|:.:|||||...|..|.||..||.|.|.:| .|:
Mouse  1210 VFSGALKSSSGYLAKSSIVEDGVMVQITAENMDSLRQALREMKDFTITCGKADAEDPQEQI-HIQ 1273

  Fly  1186 WVDNNRDINVGVKSPIDDQPMDGISNMRVLKWASFNYSNTNYAIRLSDIYIIKCEDWYATNGGNC 1250
            |||:::.:|.||.||||.:.|:.|:|:::...:  .|......||.::::.::.:|.:     ||
Mouse  1274 WVDDDKTVNKGVVSPIDGKSMESITNVKIFHGS--EYKANGKVIRWTEVFFLENDDHH-----NC 1331

  Fly  1251 ----EEITRIAEQLARSASMALLPLLDLLAAAGINKLGLRATLDQDNVGYEAGARGSKLPPLYMN 1311
                .:.:|:.|.:|::..:||.|.|.||...|:.|||||.|||.|.|||:||:.|..||..|||
Mouse  1332 LSDPADHSRLTEHVAKAFCLALCPHLKLLKEDGMTKLGLRVTLDSDQVGYQAGSNGQPLPSQYMN 1396

  Fly  1312 ALDNHLIATLHGESSGIQE-PIILELIFYIL 1341
            .||:.|:..:||.:..:.| |:::|||||||
Mouse  1397 DLDSALVPVIHGGACQLSEGPVVMELIFYIL 1427

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sara	NP_524729.2	FYVE_endofin	522..589	CDD:277268	36/66 (55%)
		SARA	614..650	CDD:288292	26/38 (68%)
		DUF3480	959..1321	CDD:288806	175/365 (48%)
Zfyve9	XP_006503049.1	FYVE_endofin	696..763	CDD:277268	36/66 (55%)
		SARA	779..817	CDD:371513	26/38 (68%)
		DUF3480	1054..1406	CDD:371829	175/365 (48%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849179
Domainoid	1	1.000	336	1.000	Domainoid score	I1115
eggNOG	1	0.900	-	-		E1_KOG1841
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	579	1.000	Inparanoid score	I1023
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003142
OrthoInspector	1	1.000	-	-		otm43015
orthoMCL	1	0.900	-	-		OOG6_105532
Panther	1	1.100	-	-	O	PTHR46319
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2928
SonicParanoid	1	1.000	-	-		X2534
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.780