DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sara and Zfyve16

DIOPT Version :9

Sequence 1:	NP_524729.2	Gene:	Sara / 44263	FlyBaseID:	FBgn0026369	Length:	1343	Species:	Drosophila melanogaster
Sequence 2:	NP_775568.1	Gene:	Zfyve16 / 218441	MGIID:	2145181	Length:	1528	Species:	Mus musculus

Alignment Length:	1543	Identity:	450/1543 - (29%)
Similarity:	669/1543 - (43%)	Gaps:	367/1543 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 DIDQVLDNLELSIAADEQLSRNAAAAAAAGANPGRFLGDGASASISGVGAGAGV------SGAAG 63
            ||.|:|.: :...:||..::.::::.:.|             .::|.|..|:..      :..||
Mouse   142 DIKQLLPD-DPKSSADTLITLDSSSVSEA-------------LTVSSVDCGSNAVREEQNNINAG 192

  Fly    64 VTPTPASGKSFVGVS---QVFNSLDDYR-ENVKSLQVDAQLPSYDWQTEAEHEDDIHKFSEQASK 124
            :.....|.|. :||.   .:|:|....| ||:|...:..:|.:.|:...:...:...:.|.  :|
Mouse   193 IKNRDISIKE-LGVKVDMALFDSCKYNRTENLKDKIISNELETVDFDMPSVLMEQSSEMSN--TK 254

  Fly   125 NNGQTIVSSSESLTTSSCSTFSSGPSPVSN------GSHSEELATP---PEDEKTSEVQVEPKEQ 180
            :|.|......|.|....|.........|:|      |..|..:|.|   ||:|     .:.|.:.
Mouse   255 DNPQYKRLPCELLKDDGCLAEEKVAVAVNNTECLEEGGGSNTIAMPCKLPENE-----GISPSDP 314

  Fly   181 DQQPEQVKHEDQHQDQAVPPPTQS-------KQTVEE--------------------LAVGLSSI 218
            ..:.|..|..|.        |.|.       ||||:|                    :...||.:
Mouse   315 ASKDENFKLPDF--------PLQENRTSVFMKQTVKEDSRNLDLKDNNDIVHVSGDDVPPSLSCL 371

  Fly   219 SITAS-------GTESQSLLP---------------EEVTASSVL-------------------- 241
            |::.|       ..|...:||               ||:..|.||
Mouse   372 SLSGSLCGSLIHNNEHSDILPPNESEGQNNDAVTIHEEIQKSDVLDGETDLSKKETCRSIFLQPV 436

  Fly   242 ------GQV-LEE--LSEESSPSREPETEMTNGIDVPLANLPASVAEVPVPKEMEQPVQTEEEDV 297
                  |:| :||  :|.||..|.| :.........|:|...|||.|.|.|.|
Mouse   437 NEKKGEGKVEVEEMVISGESLESPE-DASSAAAAGSPVALSAASVPEAPGPCE------------ 488

  Fly   298 ELPQEQHPRRSQPLTFCST-----------MDE-------ISDTELDSMLQE--------MDADD 336
                        .|||.|:           :||       |||.|||:.|:|        |.|.:
Mouse   489 ------------GLTFPSSDMDGQELDYFNIDESMRSGILISDAELDAFLKEQCLSNSNTMSAGE 541

  Fly   337 NQADDQ-QMPD-------DEK------SCSASPVTEEESV-RILSDEQETTSNDQMNVDNFSQAS 386
            |..|.| ||..       ||.      :..|....|...| ...:.::|.|.|:.:::.......
Mouse   542 NVNDSQLQMNQITMKGLHDENAGDIYFNAEAGAAGENGGVGNCETSDKENTENNGLSIGEKGAIP 606

  Fly   387 TVEFADLKQPE--------STPVTAMGEDVASSFSSTESDSLSGRKLDGEVEVD-REHEDASLAT 442
            |.......||:        |....|:|........|....:.|.::|:....|| .|.|..:...
Mouse   607 TERELSACQPDIRDELPVPSIKTQAVGGARPKQLLSLPPGTRSSKELNKPDVVDVPESEPCTANA 671

  Fly   443 DALET--QEQRPQRPQTLNLNGCQAESS--------TPSQDENPEIQQETLQPTEVREGAAGVGV 497
            .|:.|  .:..|....:.|.|....||:        |.::|..||.::
Mouse   672 TAVSTCSADHIPDSQVSFNSNYIDIESNFEDGSSFVTANKDSLPENKR----------------- 719

  Fly   498 IPGEDDEESPIYEAVGYSDPHANLGKVPPIWVPDNMAGQCMQCQQKFTMIKRRHHCRACGKVLCS 562
                  :||.:            ||:..|.||||:.|..||.||.|||..||||||||||||.|.
Mouse   720 ------KESLV------------LGQKQPTWVPDSEAPNCMNCQVKFTFTKRRHHCRACGKVFCG 766

  Fly   563 VCCSQRFRLEFATEPESRVCVQCYMILSERQANGLNSESAPGSALPPTPIRSPNPNNPMEYCSTI 627
            |||:::.:|:: .|.|:||||.||..:::.||  .....:||.:.    ::|.:.|.    |:|.
Mouse   767 VCCNRKCKLQY-LEKEARVCVICYETINKAQA--FERMMSPGGSC----LKSNHSNE----CATD 820

  Fly   628 PPHRQVANSPGAPPPSVIVPVGVLKK--TDGSSSNSSSSDGQKGQRKRKSVMFSDGIAPGSELAS 690
            .|.::...| ..|.|:.: |:..||:  .:|..|           :::|.|.|:|||.|..|:|.
Mouse   821 QPLQETQTS-STPSPTTL-PISALKQPNVEGPCS-----------KEQKRVWFADGILPNGEVAD 872

  Fly   691 TMEQQWGESKHSRRGLSRSGSGAGQKPPT----------PATEEPPRSIDTSSTLGLVAQLFRGS 745
            |.:...|..:     .|...|......||          |..|:|      ::.||   .:.|..
Mouse   873 TTKLSSGSKR-----CSDDFSPVLPDVPTMINKVDRTHSPTVEKP------NNGLG---DIIRSE 923

  Fly   746 IPPSAAAATLSATETSAGRSSSQSQAQTSPRR--------KAESSRNRKLPPNG----------- 791
            |..|....| :..|...|.:.::......|..        ..|.|....:|.|.
Mouse   924 ISQSPTCHT-APVERLPGNTGTEGLPMPGPFTLEDDVFVDSEEPSTPTVVPANSGLPVASISDYR 987

  Fly   792 ---DAQGC------YLPPEENGLPPICISSKEGGEVDYKVVRNDGS---LLDRLQNE---TLKFI 841
               ....|      .||.::.||||:..:|.|.|.|  .||:...|   ::..|:.|   ...|:
Mouse   988 LLCSVAKCVCNNISLLPDDDIGLPPLLATSGEDGSV--PVVQERPSHEQIILLLEGEGFPPATFV 1050

  Fly   842 IKNNFFVLVKIVNMSCCMNRWVLNFTTSGLHHMGSDELIILLEIKQPKQEEYVKGEVAIPKDLFQ 906
            :..|..|.||:|..| ....|.  |:|:|||.:|..|:|:||:.        :..|..:|||:|:
Mouse  1051 LNANLLVNVKLVLYS-SEKYWY--FSTNGLHGLGQAEIIVLLQC--------LPNEDTVPKDIFR 1104

  Fly   907 HLYEIYVEAEHAR--SGTHELAFTSPRNANFLGSREHGGFIFIRPTYQCLQGVIVPDNPYLVGVL 969
            ....||.:|...:  .....|.||.    :||.|::||||:||.||:|.|.|:.||.:|:|.|:|
Mouse  1105 LFITIYKDALKGKYIENLDNLTFTE----SFLNSKDHGGFLFITPTFQNLDGLPVPRSPFLCGIL 1165

  Fly   970 IHRHEVPWAKVLPLRLILRLGAQYRYYPCPLISVRGRESVYGEIAQTIINFLVDFRNYSYSLPAI 1034
            |.:.|:|||||.|:||:|||||:|:.||.||.|||||:.::|||..||:|.|||.|||.|:|..|
Mouse  1166 IQKLEIPWAKVFPMRLMLRLGAEYKAYPAPLTSVRGRKPLFGEIGHTIMNLLVDLRNYQYTLHNI 1230

  Fly  1035 RGLYIHMEDRQTTVIIPKYRQQDVIKAINNASDHILAFAGNFSKVADGHLVCMQNINDDRSEMYS 1099
            ..|.||||..::.:.||:.:..||:|.|:::::|:::...:||..||.||||:|:..       .
Mouse  1231 DQLLIHMEMGKSCIKIPRKKYSDVMKVIHSSNEHVISIGASFSTEADSHLVCVQSDG-------V 1288

  Fly  1100 YSTQAINIQGQPRKITGASFFVLNEALKSSSGLSGKCSIVEDGLMVQIMPAKMEEVRQALRNQND 1164
            |.|||.:..|||||:|||||.|.|.|||:|||...|.|||||||||||.|..||.:|.|||.|.|
Mouse  1289 YQTQANSATGQPRKVTGASFVVFNGALKTSSGFLAKSSIVEDGLMVQITPETMEGLRLALREQKD 1353

  Fly  1165 IDIVCGPIDATDDQSEIVSIKWVDNNRDINVGVKSPIDDQPMDGISNMRVLKWASFNYSNTNYAI 1229
            ..|.||.:||. |..|.|.|.|||:....|.||.|.:|...::|..:.::.  ...::......:
Mouse  1354 FRIQCGKVDAV-DLREYVDICWVDSEERKNKGVISSVDGMSVEGFPSEKIK--LETDFETEEKTV 1415

  Fly  1230 RLSDI-YIIKCEDWYATNGGNCEEITRIAEQLARSASMALLPLLDLLAAAGINKLGLRATLDQDN 1293
            :.::: |.:|.:|....:..     .:.|:::|.:.|.||.|.|..|.:..:||:|||.::|.|.
Mouse  1416 KCTEVFYFLKDQDISILSSS-----YQFAKEIAVACSAALCPHLRTLKSNRMNKIGLRVSIDTDM 1475

  Fly  1294 VGYEAGARGSKLPPLYMNALDNHLIATLHGESSGIQEPIILELIFYIL 1341
            |.::||..|..||..|:|.||:.||..:||.:|....|:.:||.|:||
Mouse  1476 VEFQAGCEGQLLPQHYLNDLDSALIPVIHGGTSNSSLPLEIELAFFIL 1523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sara	NP_524729.2	FYVE_endofin	522..589	CDD:277268	39/66 (59%)
		SARA	614..650	CDD:288292	9/35 (26%)
		DUF3480	959..1321	CDD:288806	158/362 (44%)
Zfyve16	NP_775568.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	629..664		7/34 (21%)
		FYVE_endofin	726..792	CDD:277268	39/66 (59%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	819..849		8/31 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	928..949		3/21 (14%)
		DUF3480	1155..1503	CDD:288806	158/362 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849180
Domainoid	1	1.000	336	1.000	Domainoid score	I1115
eggNOG	1	0.900	-	-		E1_KOG1841
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S6349
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003142
OrthoInspector	1	1.000	-	-		otm43015
orthoMCL	1	0.900	-	-		OOG6_105532
Panther	1	1.100	-	-	LDO	PTHR46319
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2928
SonicParanoid	1	1.000	-	-		X2534
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.680