DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sara and ZK632.12

DIOPT Version :9

Sequence 1:	NP_524729.2	Gene:	Sara / 44263	FlyBaseID:	FBgn0026369	Length:	1343	Species:	Drosophila melanogaster
Sequence 2:	NP_499183.1	Gene:	ZK632.12 / 176397	WormBaseID:	WBGene00014019	Length:	266	Species:	Caenorhabditis elegans

Alignment Length:	257	Identity:	67/257 - (26%)
Similarity:	99/257 - (38%)	Gaps:	61/257 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   404 MGEDVASSFSSTESDSLSGRKLDGE---VEVDR---EHEDASLATDAL-----ETQEQRPQRPQT 457
            |||.:          |:.||.|.||   |::.|   :.....|..|.|     ...::|..:.:.
Worm    25 MGEQL----------SVFGRVLVGEGVLVKMCRKKPKQRQFFLFNDILVYGNIVISKKRYNKQRI 79

  Fly   458 LNLNGCQAES-------------STPSQDENPEIQQETLQPTEVREGAAGVGVIPGEDDEESPIY 509
            |.|.|.|.|.             .||::........|    ||.||....:         |..:.
Worm    80 LRLEGVQVEDLEDDGIEKHGWIIKTPAKSFAVYAATE----TEKREWMLHI---------ERCVT 131

  Fly   510 EAVGYSDPHANLGKVPPIWVPDNMAGQCMQC-QQKFTMIKRRHHCRACGKVLCSVCCSQRFRLEF 573
            :.:...:..|..... .:||||..|.:||.| :.:|.:::||||||.||:|:|..|.|:.||::.
Worm   132 DLLERGNKQAATAHA-AVWVPDGEAVKCMVCGKTQFNLVQRRHHCRNCGRVVCGACSSRTFRIDN 195

  Fly   574 ATEPESRVCVQCYMILSERQANGLNSESAPGSALPPTPI------------RSPNPNNPMEY 623
            ..:...|||..|:..||........||...|:.|.....            ||.|.:.|..|
Worm   196 VHKKPVRVCDHCFDSLSSATPGQEESEPKTGNRLHHEDSSSDSEDEVNGSGRSSNESRPTFY 257

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sara	NP_524729.2	FYVE_endofin	522..589	CDD:277268	27/67 (40%)
		SARA	614..650	CDD:288292	4/10 (40%)
		DUF3480	959..1321	CDD:288806
ZK632.12	NP_499183.1	PH_Phafin2-like	7..129	CDD:269927	28/126 (22%)
		PH	39..130	CDD:278594	20/103 (19%)
		FYVE_PKHF	148..208	CDD:277257	26/59 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2928
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.030