Protein Alignment Sara and aka-1

DIOPT Version :9

• Sequence 1: NP_524729.2
• Gene: Sara / 44263
• FlyBaseID: FBgn0026369
• Length: 1343
• Species: Drosophila melanogaster
• Sequence 2: NP_495565.2
• Gene: aka-1 / 174216
• WormBaseID: WBGene00000101
• Length: 1284
• Species: Caenorhabditis elegans
• Alignment Length: 1510
• Identity: 332/1510 - (21%)
• Similarity: 583/1510 - (38%)
• Gaps: 415/1510 - (27%)

  Fly     2 DLVDIDQVLDNLELSIAADEQLSRNAAAAAAAGANPGRFLGDGASASISGVGAGAGVSGAAGVTP 66
            ::.|:|.:||.:|      ..|.:...:..:....|...:|                ....|:..
 Worm     3 EVPDMDDLLDEME------SDLVKKCCSVQSKPLLPPTSIG----------------MQPRGIKH 45

  Fly    67 TPASGKSFVGVSQVFNSLDDYRENVKSLQVD-AQLPSYDWQTEA-----EHEDDIHKFSEQASKN 125
            .||. ::.|.||:...|.|...:...::.:| :|||: .:||::     ..|.:|.|.:|.:::
 Worm    46 NPAP-RTVVTVSKFVISEDMNEQMEGNINIDTSQLPN-TFQTKSSFPPNSDERNIGKENEVSAR- 107

  Fly   126 NGQTIVSSSESL-TTSSCSTFSSGPSPVSN--GSHSEELATP-PEDEKTSEVQVE---PKEQ--- 180
              |.|....:|: ..|..:.|......::.  ...||..:.| ||.|:.|||:.:   |:.|
 Worm   108 --QEIAHKLKSVHNYSDATNFDPSKKVITQKFSQESEPESEPEPEPEEVSEVEEDTLVPETQIIS 170

  Fly   181 -------DQQP------------------------------------------------------ 184
                   |.:|
 Worm   171 NLNATARDTEPTATISKPNLDLDTEMEDMLAYLNDESVDKSSLKDKPAREEGGRDSIEESANESA 235

  Fly   185 --------------EQVKHEDQHQDQAVPPPTQSKQTVEEL-AVGLSSI--SITASGTESQSLLP 232
                          |.:.|...|.|.||....::..:|.:: |:.|.|.  |:.:...::.:.|.
 Worm   236 LYQFADRFSELVISEALNHRKMHYDPAVKEFYEANDSVPDVFAMSLDSTHSSLNSFNADNHNYLS 300

  Fly   233 EEVTASSVLGQVLEELSEESSPSREP-----ETEMTNGIDVPLANLPASVAEVPVPKEMEQPVQT 292
            |...:|.  .:.::.::||:..|.||     |||         .||.....:|...:..|..||.
 Worm   301 EPENSSK--KERMQSVAEENEASEEPTQSSSETE---------KNLQNEKIDVEFIENSEAIVQN 354

  Fly   293 EEEDVELPQEQHPRRSQPLTFCSTMDEISDTELDSMLQEMDAD---DNQADDQQMPDDEKSCSAS 354
            |.|||  |:.               :..|.|.|:::...:::|   :|.::...:.:.....|.:
 Worm   355 ESEDV--PES---------------NSTSGTVLENIEDHLESDVVIENGSESSFVNEKMNEASTA 402

  Fly   355 PVTEEESV------RILSDEQETTSNDQMNVDNFSQASTVEFADLKQPESTPVTAMGEDVASSFS 413
            .:..|:||      .:.:::|||.|.:  ..|:.:..::.||.|  :...:..:...|:|..:..
 Worm   403 HLVAEQSVVDDSEIHLETEDQETLSPE--TADSSTNKNSDEFPD--EGSQSEASVNNEEVLENVE 463

  Fly   414 STESDSLSGRKLDGEVEVDREHEDASLATDALETQEQRPQRPQTLNLNGCQAESSTPSQDENPEI 478
            ..|.:..       .|:...|:.|:|:..:..|..|.||:...::
 Worm   464 HVEDECT-------VVDAVNENTDSSIEENDEENTENRPRFDSSI-------------------- 501

  Fly   479 QQETLQPTEVREGAAGVGVIPGEDDEES--PIYEAVGYSDPHANLGKVPPIWVPDNMAGQCMQCQ 541
                          |.:.|:...|.:||  |..|. ..::....|||..|.|:||:....||.|.
 Worm   502 --------------ATIHVLHESDSDESATPRRER-RLTESELQLGKTSPYWIPDSECPNCMLCN 551

  Fly   542 QKFTMIKRRHHCRACGKVLCSVCCSQRFRLEFATEPES-----RVCVQCYMILSERQANGLNSES 601
            .:||:|.|||||||||:|||..||:::..||:..|...     |||..|..:|:..:.:..:.:.
 Worm   552 TRFTIITRRHHCRACGRVLCGSCCNEKAFLEYLQEEGKKLQAVRVCKPCSAMLARIETHEQDEQR 616

  Fly   602 APGSALPPTPIRSPNPNNPMEYCSTIPPHRQVANSPGAPPPSVIVPVGVLK--------KTDGSS 658
            ...|      |.|.|..:..|..|:|            |..|..:|.||||        :.||:|
 Worm   617 RRES------IASENGLSGDETISSI------------PAASTSIPRGVLKTKPTVHVNEEDGAS 663

  Fly   659 SNSS--SSDGQKGQRKRKSVMFSDGIAPGSELASTMEQQWGESKHSRRGLSRSGSGAGQKPPTPA 721
            ::|.  |:.|......|:||||.||:.||:                                 ||
 Worm   664 TSSQAHSTSGNVSDSSRRSVMFRDGVRPGA---------------------------------PA 695

  Fly   722 TEEPPRSIDTSSTLGLVAQLFRGSIPPSAAAATLSATETSAGRSSSQSQAQTSPRRKAESSRNRK 786
            .|..|..                             ..::|.:...:|:.:||..|:....|..
 Worm   696 DEGNPEE-----------------------------ERSTALKPKKKSRKRTSVVRRIAELRME- 730

  Fly   787 LPPNGDAQGCYLPPEENGLPPICISSKEGGEVDYKVVRNDGSLLDRLQN-ETLKFIIKNNFFVLV 850
                 |...|.||.|  |:..:.|...   :.::....:..::|:.|.| ..:..::|.|....|
 Worm   731 -----DELACALPKE--GITKLLIVKP---DCEHPKFEDASTVLETLCNFSVVTVVLKKNLNCTV 785

  Fly   851 KIVNMSCCMNRWVLNFTTSGLHHMGSDELII----------LLEIKQPKQEEYVKGEVAIPKDLF 905
            :|.|.......|.:  :|.|...:|.|||:.          .::.::|:.:| ....|.:|..:.
 Worm   786 QIFNNPNFGLVWAV--STQGFAQIGLDELMFSWTLNDQEKQKVDAEEPELDE-KSALVVLPLPVL 847

  Fly   906 QHLYEIYVEA-EHARSGTHEL--------AFTSPRNANFLGSREHGGFIFIRPTYQC-LQGVIVP 960
            ..:..||.:: ||..:|..::        :.|.|.    ....:|  .:|.|||.|. |:.:.:|
 Worm   848 HRISLIYTQSTEHEYAGVRKVENRLMRVHSVTDPT----YPLTKH--IMFFRPTVQVGLKNMRIP 906

  Fly   961 DNPYLVGVLIHRHEVPWAKVLPLRLILRLGAQYRYYPCPLISVRGRESVYG-EIAQTIINFLVDF 1024
            .||:|:...:|..|:.||..||.||:.:||.::..:|.|.::..||||.|. :::.|::....||
 Worm   907 TNPFLIACFLHDDELNWATALPNRLLYKLGEKFNVFPTPFVNSIGRESTYSTDVSGTVLKVFTDF 971

  Fly  1025 RNYSYSLPAIRGLYIHMEDRQTTVIIPKYRQQDVIKAINNASDHILAFAGNFSKVADGHLVCMQN 1089
            |::||.:..|.|..:.:.:.:|.:.|||...:: :|.:.|.|..::|::.:.....|..|||
 Worm   972 RSWSYRMRHISGCTVSLTNDKTVIRIPKSAIKE-LKDVLNFSRSMVAWSCDLHCEDDSVLVC--- 1032

  Fly  1090 INDDRSEMYSYSTQ--AINIQGQPRKITGASFFVLNEALKSSSGLSGKCSIVEDGLMVQIMPAKM 1152
               :.::...||||  |.|| || |:.|.|||.:|:...|.|   |.:.::||||:.|::...::
 Worm  1033 ---EETDPGLYSTQVFAKNI-GQ-RESTSASFVILDGGSKVS---SLQVNVVEDGVAVRLQSERL 1089

  Fly  1153 EEVRQALRNQNDIDIVCGPIDATDDQSEIVSI----KWVDNNRDINVGVKSPID-----DQPMDG 1208
            |.:..|:.:.||      .::::.|....|..    .|:..:.|..  .||.||     ::...|
 Worm  1090 ETILNAINDGND------AVESSKDMEFRVEFVEDGNWICTDSDYY--PKSQIDGLYLINKFQYG 1146

  Fly  1209 ISNMRVLKWASFNYSNTNYAIRLSDIYIIKCEDWYATNGGNCE-----EITRIAEQLARSASMAL 1268
            :|..|.|..........:|.||:|.:|.:        ..|..:     :|..:.|..||.....|
 Worm  1147 LSLERALTQVLQVQGINDYGIRMSHVYNL--------GDGRLQPEEEPKIYGMIEIAARECVAML 1203

  Fly  1269 LPLLDLLAAAGINKLGLRATLDQDNVGYEAG------ARGSKLPPLYMNALDNHLIATLHGESSG 1327
            .|.:..|..|||..:.:|..:......|:..      |...|    |..:||..:
 Worm  1204 EPHIQHLICAGIGSVSIRLFVSPYEFEYDVSKWLGLEAENDK----YKQSLDQLI---------- 1254

  Fly  1328 IQEPIILELIFYILN 1342
               |::..::.|:.|
 Worm  1255 ---PMLYNMVEYVPN 1266

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sara	NP_524729.2	FYVE_endofin	522..589	CDD:277268	33/71 (46%)
		SARA	614..650	CDD:288292	8/35 (23%)
		DUF3480	959..1321	CDD:288806	103/384 (27%)
aka-1	NP_495565.2	PTZ00341	<334..>477	CDD:173534	32/170 (19%)
		FYVE_endofin	532..604	CDD:277268	33/71 (46%)
		DUF3480	905..1257	CDD:371829	104/396 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	112	1.000	Domainoid score	I3897
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003142
OrthoInspector	1	1.000	-	-		oto19192
orthoMCL	1	0.900	-	-		OOG6_105532
Panther	1	1.100	-	-	LDO	PTHR46319
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2928
SonicParanoid	1	1.000	-	-		X2534
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.940