Protein Alignment Sara and Sara

DIOPT Version :10

• Sequence 1: NP_524729.2
• Gene: Sara / 44263
• FlyBaseID: FBgn0026369
• Length: 1343
• Species: Drosophila melanogaster
• Sequence 2: XP_061496727.1
• Gene: Sara / 1270913
• VectorBaseID: AGAMI1_006840
• Length: 1394
• Species: Anopheles gambiae
• Alignment Length: 1517
• Identity: 525/1517 - (34%)
• Similarity: 776/1517 - (51%)
• Gaps: 299/1517 - (19%)

  Fly     1 MDLVDIDQVLDNLELSIAADEQLSRNAAAAAAAGANPGRFLGDGASASISGVGAGAGVSGAAGVT 65
            |||||||:|||:|||:     :...|:.|...|          .|.|:::|..|....:..|.:.
Mosquito     1 MDLVDIDKVLDDLELN-----EDDGNSVATRPA----------DAKATVNGTAADPQSAVVAALG 50

  Fly    66 PTPASGK------SFVGVSQVFNSLDDYRENVKSLQV-----DAQLP-SYDWQTEAEHE------ 112
            |..|:.:      :.|.||.||:||::| .|....::     ...|| |:|....:|.:
Mosquito    51 PATAAQEKLKFKANVVNVSTVFSSLNEY-VNAGGTELGGATKHVSLPDSHDLGIPSERKPLLTPP 114

  Fly   113 ------DDIHKFSEQASKNNGQT---------IVSSSESLTTSSCSTFSSGPSPVSNGSHSEELA 162
                  .::...|..|:.::..|         ..|...|.::.||.:.....|..|:.:||...:
Mosquito   115 STSSISSEVKTSSAAATSSSVPTSPQHVASTPATSPDSSASSVSCCSSRVASSSASSSAHSSSAS 179

  Fly   163 TPPEDEKTSEVQVEPKEQDQQPEQVKHEDQHQDQAVPPPTQSKQTVEELAVGLSSISITASGTES 227
            :......:|:|:    |.|:|.|...||..|:..   |...|..:.::..:..||::..|:..|.
Mosquito   180 SSSSSASSSDVE----EADKQQEAKGHELAHEKL---PEELSSLSGDDYVLDTSSMTTLATTNEG 237

  Fly   228 -------------------QSLLPEEVTASSVLGQVLEELSEESSPSREPETEMTNGIDVPLANL 273
                               ::.|..:..::.|:.  ||.:|..||   ....:::....|||...
Mosquito   238 GARKGTTAGDAQDTSAFSYKNSLYSDTLSNDVIN--LEGISSISS---IVAVDLSRSGQVPLVRE 297

  Fly   274 PASVAE-VPVPK-EMEQPVQTEEEDVELPQEQH---PRRSQPLTFCSTMDEISDTELDSMLQEMD 333
            ...|.| .||.| |:|   .|.::|||.|.:.|   ..|...:.|.||||::|||||:|.|||::
Mosquito   298 TNEVVEGAPVAKDEIE---TTAQDDVERPGKPHEGEDARKPVIGFESTMDDVSDTELESYLQELE 359

  Fly   334 ADDNQADDQQ-----MPDDEKSCSASP-----------------------------VTEEESVRI 364
            ..|.::.:.:     .|:.|......|                             ..:|.|:..
Mosquito   360 EFDFRSVNVESAMPPKPNAESVTELDPAVTTESQQPEIDAPAGGDVEHGSMIVQDRAADENSIDS 424

  Fly   365 LSDEQ--ETTSNDQMNVDNFSQASTVEFADLKQPESTPVTAMGEDVASSFSSTESDSLSGRKLDG 427
            .||::  .::|..:...|..|||||:||.||....:..|.|. ..||::...::....:..:|:.
Mosquito   425 RSDDEISPSSSRGENEDDLISQASTLEFNDLAMGATAAVVAT-TPVAAAVDPSDRALAAASELEI 488

  Fly   428 EVEVDREH-------EDAS--LATDALETQEQR------------------PQRPQTLNLNGCQ- 464
            .:.:|.|.       ||.|  ...|..||:.:|                  |:||.:|.|....
Mosquito   489 PIPIDTEEPGDFTLDEDGSEIRFIDCTETESERRLGQSAAGEDDPANVVPHPERPTSLELGSVAV 553

  Fly   465 -------------------------------AESSTPSQDENPEIQQETLQPTEVREGAAGVGVI 498
                                           |.|||.|.|....|:..|.......|.|:.:.:
Mosquito   554 VNEAGLTDGGIAASPGHTPPSSRVIVPEQGLALSSTSSDDFGTSIEARTASHAAEEEAASRLAI- 617

  Fly   499 PGEDDEESPIYEAVG----YSDPHANLGKVPPIWVPDNMAGQCMQCQQKFTMIKRRHHCRACGKV 559
              .|..:|||...|.    .|...|.|||:.|.|||||....||||.|||::|||||||||||:|
Mosquito   618 --ADPIQSPIAAPVPVVPLLSPAQAQLGKIQPFWVPDNSTKFCMQCNQKFSVIKRRHHCRACGQV 680

  Fly   560 LCSVCCSQRFRLEFATEPESRVCVQCYMILSERQANGLNSESAPGSALPPTPIRS---------- 614
            |||.||..:.:||:..:.|:|||::|.:|||.:|...:.:|....:.:.....||
Mosquito   681 LCSTCCCLKAKLEYLGDVEARVCIECDVILSIQQQQAMEAEQYQLAGMQSGDSRSSLAVSGASGQ 745

  Fly   615 --PNPNNPMEYCSTIPPHRQVA--NSPGAPPPSVIVPVGVLKKTDGSSSNSSSSDGQKGQRKRKS 675
              |||||||||||.|||.:|.|  |.|.: |.||:|||||||:. |:..|         .||.|:
Mosquito   746 RQPNPNNPMEYCSVIPPLQQAAASNQPQS-PISVMVPVGVLKRA-GAPRN---------MRKDKN 799

  Fly   676 VMFSDGIAPGSELASTMEQQWGESKHSRRGLSRSGSGAGQKPPTPATEEPPRSIDTSSTLGLVAQ 740
            |:|||||.||.:| :.::|.|                    ...|....|||
Mosquito   800 VIFSDGIRPGCDL-TELDQNW--------------------DAVPTRTSPPR------------- 830

  Fly   741 LFRGSIPPSAAAATLSATETSAGRSSSQSQAQTSPRRKAESSRNRKLPPNGDAQGCYLPPEENGL 805
                                  ||   :.:.||.|  ..|...| .:|..|......:|.|||.|
Mosquito   831 ----------------------GR---KPRVQTPP--GGEDDVN-AIPRVGGQLASLIPAEENKL 867

  Fly   806 PPIC--ISSKEGGEVDYKVVRNDGSLLDRLQNETLKFIIKNNFFVLVKIVNMSCCMNRWVLNFTT 868
            ||:.  ||..|...|:   :.||.|||:.|:..||.|.|:.||.|||.:|.::||:||.|:||||
Mosquito   868 PPVLKRISPTESKLVE---IENDASLLEGLREVTLTFAIQKNFHVLVTVVELACCINRTVINFTT 929

  Fly   869 SGLHHMGSDELIILLEIKQPKQEEYVKGEVAIPKDLFQHLYEIYVEAEHARSGTHELAFTSPRNA 933
            .|||::|.||:||||.:...:         .:|||:|.||.|||.||:.....| ||.|:..|:.
Mosquito   930 RGLHYVGQDEIIILLVLGDSR---------VLPKDIFVHLNEIYCEADRGHIIT-ELGFSPARSN 984

  Fly   934 NFLGSREHGGFIFIRPTYQCLQGVIVPDNPYLVGVLIHRHEVPWAKVLPLRLILRLGAQYRYYPC 998
            |||||:.||||:::||||||::.||.|:.|||:|:||||.||||||:|||||:|||||.|:||||
Mosquito   985 NFLGSKNHGGFLYVRPTYQCMKAVIAPEAPYLIGILIHRWEVPWAKILPLRLMLRLGALYQYYPC 1049

  Fly   999 PLISVRGRESVYGEIAQTIINFLVDFRNYSYSLPAIRGLYIHMEDRQTTVIIPKYRQQDVIKAIN 1063
            |.:|.|.|||||.||||||:|.|.|||::||::|::||:.||:||.:|:::||:.|.:.::|.::
Mosquito  1050 PHVSERERESVYVEIAQTIVNLLADFRHFSYTIPSVRGMVIHLEDHKTSILIPRNRYEQMVKVVD 1114

  Fly  1064 NASDHILAFAGNFSKVADGHLVCMQNINDDRSEMYSYSTQAINIQGQPRKITGASFFVLNEALKS 1128
            .:|:.::|..|||||:|||||||:||......|...|:||||:|:.||||:|||||.||:.:||.
Mosquito  1115 GSSEQLMAVGGNFSKLADGHLVCIQNTESGCPEATQYTTQAIDIESQPRKVTGASFLVLDGSLKP 1179

  Fly  1129 SSGLSGKCSIVEDGLMVQIMPAKMEEVRQALRNQNDIDIVCGPIDATDDQSEIVSIKWVDNNRDI 1193
            :|||:|:|:|:||||.|.|.|.|::.|::||:...|..|||||.:..|.|.|:|||:|..|:.:.
Mosquito  1180 NSGLTGRCTILEDGLRVLIPPVKLQLVKEALKAMKDYQIVCGPTEGDDSQKELVSIEWTSNDLNF 1244

  Fly  1194 NVGVKSPIDDQPMDGISNMRVLKWASFNYSNTNYAIRLSDIYIIKCEDWYATNGGNCEEITRIAE 1258
            |:||.||||.:..||:.::||.:  ..:|||:|:.||.::::|:| .|..:.:.|:...:::|:|
Mosquito  1245 NIGVTSPIDRKAFDGVPSIRVHR--GTDYSNSNHIIRWTEVFILK-GDEESNHPGDPINMSKISE 1306

  Fly  1259 QLARSASMALLPLLDLLAAAGINKLGLRATLDQDNVGYEAGARGSKLPPLYMNALDNHLIATLHG 1323
            .:|::|..||:..|||||:.|..||.||.:.::..:.|.||:.|::|.|||.|||...::..|..
Mosquito  1307 TVAKTACKALVEYLDLLASNGHTKLALRISSNRGQMAYVAGSGGNQLAPLYSNALGQAVMELLER 1371

  Fly  1324 ESSGIQ---EPIILELIFYILN 1342
            :::.:.   ..|:.||||:||:
Mosquito  1372 QATALHLDLHDIVFELIFHILD 1393

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sara	NP_524729.2	FYVE_endofin	522..589	CDD:277268	39/66 (59%)
		SARA	614..650	CDD:463271	25/49 (51%)
		DUF3480	959..1321	CDD:463419	178/361 (49%)
Sara	XP_061496727.1	None