Protein Alignment Sara and zfyve9

DIOPT Version :10

• Sequence 1: NP_524729.2
• Gene: Sara / 44263
• FlyBaseID: FBgn0026369
• Length: 1343
• Species: Drosophila melanogaster
• Sequence 2: XP_004914061.2
• Gene: zfyve9 / 100496662
• XenbaseID: XB-GENE-853438
• Length: 1320
• Species: Xenopus tropicalis
• Alignment Length: 1455
• Identity: 457/1455 - (31%)
• Similarity: 688/1455 - (47%)
• Gaps: 314/1455 - (21%)

  Fly    10 LDNLELSIAADE-------------QLSR--NAAAAAAAGANPGRFLGDGASASISGVGAGAGVS 59
            |||:..||.|.|             ::|.  |...:..|...|...:||...|..|....    :
 Frog    53 LDNVCKSIIAIEAHLKVRSPSLTALEISTFVNGEVSIVAPEMPKMVIGDTIMAEDSFFNN----T 113

  Fly    60 GAAGVTPTPASGKSFVGVSQVFNSLDDYR---ENVKSLQVDAQL-PSYDWQT-------EAEHED 113
            |.:.:...|::.:     ||....|||..   .|.||:.:|... |....:|       ..::|.
 Frog   114 GPSEIVCNPSTVE-----SQSLQVLDDVSVSIHNEKSVLLDDGFSPCSSPKTVINPVCLTMDNET 173

  Fly   114 DIH-------KFSEQASKNNGQTIVSSSESLTT-----------------------------SSC 142
            .:|       |..|..|.:...||:..:.:|:|                             |:|
 Frog   174 PLHEQIIVNDKDKETVSISVLPTIIQDTANLSTDLALNKPSTEEPYTALKETTSVILPETPYSTC 238

  Fly   143 S--TFSSGPSPVSNGSHSEELATPPEDEKTSEVQVEPKEQDQQPEQVKH-EDQHQDQ---AVPPP 201
            :  :|.:...|....::::.|:..|..|..||         |||   || ...|:::   .||..
 Frog   239 AVLSFENNKVPSCQLNNTDLLSVSPVVEACSE---------QQP---KHTSSSHEEKLFAGVPAT 291

  Fly   202 TQSKQTVEELAVGLSSISITASGTESQSLLPEEVTASSVLGQVLEE---LSEESSPSREPETEMT 263
            .....|..|..:...::    ...||..::.:..:.|.|:.....:   ||.||:..........
 Frog   292 ASFPATAVETVLNNEAL----HSAESFDIVVKNFSDSCVINGDFSKTSGLSHESNEKFYASKMFQ 352

  Fly   264 NGIDVPLANLPASVAEVPVPKEMEQPVQTEEEDVELPQEQHPRRSQPLTFCSTMDEISDTELDSM 328
            .|||..:.              :|......:|.::|.:|.  ..:.||...:..|..
 Frog   353 GGIDTNVL--------------LEDTCIASKEGMDLHEEN--GTNAPLFLYNGCDSY-------- 393

  Fly   329 LQEMDADDNQA---DDQQMPDDEKSCSASPVTEEESVRILSDEQETTSNDQMNVDNFSQASTVEF 390
                 ...|.|   :.:.:|..|.|     ||||:.:.....|..|...:|...|..::.|.:..
 Frog   394 -----GIKNPAVAHNPKNLPSKEDS-----VTEEKEIEESKLEYYTGIYEQQKEDEVTERSGLLL 448

  Fly   391 ADLKQPESTPVTAMGEDVASSFSSTESDSLSGRKLDGEVEVDREHEDASLATDALETQEQRPQRP 455
                   :..|..|..::.|..|...|       :.|:....:.....||   ::.....||::|
 Frog   449 -------NAKVDQMKNNLHSLCSQVSS-------MHGQTSPKKGKIVQSL---SVPYGGARPKQP 496

  Fly   456 QTLNLN------------------GCQAESSTP-----SQDENPEIQQETL-QPTEVREGAAGV- 495
            ..|.|:                  ||.:::...     :|.:|  :..|:| :.:.||......
 Frog   497 THLKLHIPKPLSEMLQSDLIPPNAGCSSKNKNDMLNKCNQGDN--LMSESLREESSVRSPVTDAN 559

  Fly   496 GVIPGE-------DDEESPIYE---AVGYSDPHANLGKVPPIWVPDNMAGQCMQCQQKFTMIKRR 550
            |.:||.       |..::.:..   .|..|.|...||:|.|:||||:.|..||:|:.:||..|||
 Frog   560 GEVPGSLCLAVSPDSPDNDLLAGQFGVPISKPFTTLGEVAPVWVPDSHAPNCMKCEARFTFTKRR 624

  Fly   551 HHCRACGKVLCSVCCSQRFRLEFATEPESRVCVQCYMILSERQA--NGLNSESAPGSALPPTPIR 613
            |||||||||.|:.|||.:.:|::..:.|:||||.|:.:|...||  |.|::.           ::
 Frog   625 HHCRACGKVFCAACCSLKCKLQYMDKKEARVCVICHSVLMNAQAWENMLSAS-----------VQ 678

  Fly   614 SPNPNNPMEYCSTIPPHRQVANSPGA---PPPSVIVPVGVLKK--TDGSSSNSSSSDGQKGQRKR 673
            |||||||.||||||||.:| |.:.||   |||:|:|||||||.  |:||.|        |.||:
 Frog   679 SPNPNNPAEYCSTIPPMQQ-AQASGALSSPPPTVMVPVGVLKHPGTEGSQS--------KEQRR- 733

  Fly   674 KSVMFSDGIAPGSELASTMEQQWGESKHSRRGLSRSGSGAGQKPPTPATEEPPRSIDTSSTLGLV 738
              |.|:|||.|..|.|.                |...:|
 Frog   734 --VWFADGILPNGETAD----------------SEKANG-------------------------- 754

  Fly   739 AQLFRGSIPPSAAAATLSATETSAGRSSSQSQAQTSPRRKAESSRNRKLPPNGDAQGCYLPPEEN 803
                      :|.|.||:.:.|:   :|:.|:::.:      |.....:...|.|..  |.||:
 Frog   755 ----------TAVAGTLTVSHTN---NSASSESENT------SGFCGSITQVGSAMN--LIPED- 797

  Fly   804 GLPPICISSKEGGEVDYKVVRNDG--SLLDRLQN---ETLKFIIKNNFFVLVKIVNMSCCMNRWV 863
            |||||.||:  |.:.||.|.....  |::.:|::   :.|.|::..|...:|||||.   :||..
 Frog   798 GLPPILIST--GVKGDYAVEERPSQMSVMQQLEDGGPDPLVFVLNANLLAMVKIVNY---VNRKC 857

  Fly   864 LNFTTSGLHHMGSDELIILLEIKQPKQEEYVKGEVAIPKDLFQHLYEIYVEAEHAR-SGTHELAF 927
            ..|||.|:|.:|..|::|||:.        :..|..:|||||.|..|:|.||.... .|....:|
 Frog   858 WCFTTKGMHAVGQAEIVILLQC--------LPDEKCLPKDLFSHFVELYREALAGNVVGNLGHSF 914

  Fly   928 TSPRNANFLGSREHGGFIFIRPTYQCLQGVIVPDNPYLVGVLIHRHEVPWAKVLPLRLILRLGAQ 992
            .|   .:||||:|||||:::.||||.||.:::|..|||.|:||.:.|.|||||.|:||:|||||:
 Frog   915 LS---QSFLGSKEHGGFLYVTPTYQSLQDLVLPAEPYLFGILIQKWETPWAKVFPIRLMLRLGAE 976

  Fly   993 YRYYPCPLISVRGRESVYGEIAQTIINFLVDFRNYSYSLPAIRGLYIHMEDRQTTVIIPKYRQQD 1057
            ||.|||||.|||.|:.::||...||||.|.|||||.|:||.::||.:.||.|:|::.||..|..:
 Frog   977 YRLYPCPLFSVRFRKPLFGETGHTIINVLADFRNYQYTLPVVQGLVVDMEVRKTSIKIPSNRYNE 1041

  Fly  1058 VIKAINNASDHILAFAGNFSKVADGHLVCMQNINDDRSEMYSYSTQAINIQGQPRKITGASFFVL 1122
            ::||:|.:::|:||....|:::||.||||:|  |||.    :|.||||:|..||||:|||||||.
 Frog  1042 MMKAMNKSNEHVLAIGACFNQMADSHLVCVQ--NDDG----NYQTQAISIHKQPRKVTGASFFVF 1100

  Fly  1123 NEALKSSSGLSGKCSIVEDGLMVQIMPAKMEEVRQALRNQNDIDIVCGPIDATDDQSEIVSIKWV 1187
            :.|||||||...|.||||||:||||....|:.:||:||...|..|.||..||.:.| |.|.::||
 Frog  1101 SGALKSSSGYLAKSSIVEDGVMVQITAESMDALRQSLREMKDFTITCGKADAEETQ-EHVYVQWV 1164

  Fly  1188 DNNRDINVGVKSPIDDQPMDGISNMRVLKWASFNYSNTNYAIRLSDIYIIKCEDWYATNGGNCEE 1252
            :::::.|.||.||||.:.|:.::::::...:  .|..:...||.::::.:..|:..:......:.
 Frog  1165 EDDKNFNKGVFSPIDGKSMESVTSVKIFHGS--EYKASGKIIRWTEVFFLDNEEQQSGLSDPADH 1227

  Fly  1253 ITRIAEQLARSASMALLPLLDLLAAAGINKLGLRATLDQDNVGYEAGARGSKLPPLYMNALDNHL 1317
             :|:.|.:|::..:||.|.|.||...|:.:||||.:||.|.|||:||:.|..||..|.|.||..|
 Frog  1228 -SRLTENVAKAFCLALCPHLKLLKEDGMTRLGLRVSLDSDQVGYQAGSNGQPLPARYTNDLDGAL 1291

  Fly  1318 IATLHGESSGIQE-PIILELIFYIL 1341
            :..:||.:..:.| |:.:|||||||
 Frog  1292 VPVIHGGTCQLSEGPVSMELIFYIL 1316

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sara	NP_524729.2	FYVE_endofin	522..589	CDD:277268	36/66 (55%)
		SARA	614..650	CDD:463271	26/38 (68%)
		DUF3480	959..1321	CDD:463419	166/361 (46%)
zfyve9	XP_004914061.2	FYVE_endofin	596..663	CDD:277268	36/66 (55%)
		SARA	679..717	CDD:463271	26/38 (68%)
		DUF3480	943..1295	CDD:463419	166/361 (46%)