Protein Alignment Sara and zfyve16

DIOPT Version :9

• Sequence 1: NP_524729.2
• Gene: Sara / 44263
• FlyBaseID: FBgn0026369
• Length: 1343
• Species: Drosophila melanogaster
• Sequence 2: XP_012808244.1
• Gene: zfyve16 / 100490307
• XenbaseID: XB-GENE-985796
• Length: 1443
• Species: Xenopus tropicalis
• Alignment Length: 1599
• Identity: 449/1599 - (28%)
• Similarity: 695/1599 - (43%)
• Gaps: 430/1599 - (26%)

  Fly     3 LVDIDQVLDNLELSIAADEQLSRNAAAAAAAGANP-----------------GRFLGDGAS---- 46
            :||:|::||:.|.:.   |.|....::.|:.|:|.                 |:.|.:.:|
 Frog     9 VVDLDKLLDDFEQNA---EVLENCQSSGASLGSNQCSLYSGNFCHQPEFSALGKQLNEKSSPQQA 70

  Fly    47 --------------------ASISGVGAGAGVSGAAGVTPTPASGKSFVGVSQVFNS-------- 83
                                .:::|:...:.|.|..........|::.|.|..:.:.
 Frog    71 LCSTDKDVDFQTFCPESCAEKNVTGLDLLSCVDGGGSSDDVLGPGRTSVPVCDLISDTGSLIQKD 135

  Fly    84 -----------LDD---------YRENVKSLQVDAQLPSYDWQT---EAEH-------------- 111
                       |.|         :.||.:|        |..||.   :.||
 Frog   136 TSSEPEISSTHLSDLELHSDTIIHTENTES--------SISWQVIALDCEHRTWLPINQPNLVVI 192

  Fly   112 --EDDIHKFS-EQA------SKNNGQTIVSSSESLTTSSCSTFSSGPSPVSNGSHSEELATPPE- 166
              :||....| :|.      .:|.....||:::::::|:.||        |:|..|::|  |.|
 Frog   193 SPKDDGSNISLDQVLACNLDQENRATDSVSNTDTVSSSNTST--------SDGYVSDDL--PYET 247

  Fly   167 -----------DEKTSE---------------VQVEPKEQDQQPE-QVK----------HEDQHQ 194
                       .||.::               ::...|:..|..: :||          ::....
 Frog   248 LTEGQEFLGLKGEKDTQCLPGADYEEAMNGGCIEASCKDVAQSSDVEVKGAVVCRAGRANKKPAS 312

  Fly   195 DQAVPPPTQSKQTVEELAVGLSSISITASGTESQSLLPEEVTASSVLGQVLEELSEESSPSREPE 259
            ||.:  |.............:|.:|..:|.:...|    ::..|...|.:..|:::..:|..|..
 Frog   313 DQGL--PVLGTIIASHCTGDMSDVSTDSSVSVDNS----QMECSVQKGVLSSEINQCITPCTEKN 371

  Fly   260 TEMTN------------------GID---VPLANLPASVAEVPVPKEMEQPVQTEEEDVELPQEQ 303
            |...|                  |:|   |...:||:...||.| :|::...|.:.....||...
 Frog   372 TATQNNGMRAADSISFTVLKDDKGLDVDYVQAGHLPSLAKEVDV-QEIKNLEQKKNTPYHLPTAL 435

  Fly   304 HP------RRSQPLTFC------------------STMDE--ISDTELDSMLQEMDAD-DNQAD- 340
            .|      ::.|.|...                  :.:.|  |||.|||:.|.:.|.| ..|..
 Frog   436 APNAMESRKKEQILDIAPVSSSEFKEDFLHDLISSNVLSEAYISDAELDAFLNQEDGDLSTQFTL 500

  Fly   341 DQQMPDDEKSCS-ASPVTEEESVRILSDEQETTSNDQMNVDNFSQASTVEFADLKQPESTPVTAM 404
            ....|..:..|| .||..:|.:..:.:|....|::....|                 .|.|
 Frog   501 HNDCPPYDFICSNNSPAVDETAGGLGTDSSSFTADCSPAV-----------------SSLP---- 544

  Fly   405 GEDVASSFSSTESDSLSGRKLDGEVEVDREHEDASLATDALETQEQR-PQRPQTLNLNGCQAESS 468
                  |::|.:..|:.|.:  .:|::..|:...:...|...:...: ..||:       |..:|
 Frog   545 ------SYTSKQESSVLGAQ--SQVKITSENSLPAAVKDGDNSSSHKGGARPK-------QLFNS 594

  Fly   469 TPSQDENPEIQQETLQPTEVREGAAGVGVIPGEDDE-----ESPIYEAVGYSDPH---------- 518
            .|..  .|:|.|.||..|:      |.|....|...     .|||  .:..:.||
 Frog   595 HPKL--LPDISQNTLVNTD------GQGNNKPEQSSADVTPSSPI--GIAEAQPHDLNISSVLGK 649

  Fly   519 -AN-------------------------LGKVPPIWVPDNMAGQCMQCQQKFTMIKRRHHCRACG 557
             ||                         ||:..|.|:||:.|..||.|..|||..||||||||||
 Frog   650 SANTNGSSELNRKEKGCRSENGTSQNPVLGQRQPTWIPDSEAPTCMNCSVKFTFTKRRHHCRACG 714

  Fly   558 KVLCSVCCSQRFRLEFATEPESRVCVQCYMILSERQA-NGLNSESAPGSALPPTPIRSPNPNNPM 621
            ||.|:|||||:::|.: .:.|:||||.|:.::|:.|| ..:.|.:.|          |||||.|.
 Frog   715 KVFCAVCCSQKWKLPY-MDKEARVCVVCFGLVSKVQAFERMMSPTGP----------SPNPNVPS 768

  Fly   622 EYCSTIPP--HRQVANSPGAPPPSVIVPVGVLKKTDGSSSNSSSSDGQKG-QRKRKSVMFSDGIA 683
            ||||||||  ..|.|.:..:|||:|:||..|||:           .|.:| |::.|.|.|:||:.
 Frog   769 EYCSTIPPLVQAQAAGTLNSPPPTVLVPGSVLKQ-----------PGVQGSQKEPKRVWFADGLL 822

  Fly   684 PGSELASTMEQQWGESKHSRRGLSRSGSGAGQKPPTPATEEPPRSIDTSSTLGLVAQLFRGSIPP 748
            |..|:|.|.:.. ...|.|.:.||.........|.|  |:|.|.:::
 Frog   823 PNGEVADTTKFS-SFVKRSSQDLSPEACSLPDSPMT--TDEIPNNLN------------------ 866

  Fly   749 SAAAATLSATETSAGRSSSQSQAQTSPRRKAESSRNRKLP----------PNGDAQGC------- 796
                           ....::..:|||   .:|...:.||          |:..:..|
 Frog   867 ---------------EHEKETGLETSP---VDSCMEKSLPEALSAFKVSSPSDYSMLCGLDKCVS 913

  Fly   797 ----YLPPEENGLPPICISSKEGGE--VDYKVVRNDGSLLDRLQNETLKFIIKNNFFVLVKIVNM 855
                .:|.:|..|||:.::|.|||:  ::......:..||.......:.||:..|..:.||||..
 Frog   914 RDVSLIPDDEERLPPLLLASGEGGDALIENSPTNKEVLLLLEEGLSLVTFILNANLLLNVKIVTY 978

  Fly   856 SC--CMNRWVLNFTTSGLHHMGSDELIILLEIKQPKQEEYVKGEVAIPKDLFQHLYEIYVEAEHA 918
            :.  |   |.  |:|:|||.:|..|:||||..        ::.|..:|||:|:...:||.:|:..
 Frog   979 ASEKC---WF--FSTNGLHGLGQAEIIILLAC--------LENEDILPKDMFRVFIDIYKDAQKG 1030

  Fly   919 R--SGTHELAFTSPRNANFLGSREHGGFIFIRPTYQCLQGVIVPDNPYLVGVLIHRHEVPWAKVL 981
            |  .....:.||.    :||.:::||||:|..||:|.|.|:.:|:.|:|.||:|.:.|||||||.
 Frog  1031 RYVGNLENITFTE----SFLSNKDHGGFLFFAPTFQDLTGLPLPNCPFLCGVIIQKMEVPWAKVF 1091

  Fly   982 PLRLILRLGAQYRYYPCPLISVRGRESVYGEIAQTIINFLVDFRNYSYSLPAIRGLYIHMEDRQT 1046
            |:||:|||||:...|||||:|.|.|:.::|||..||||.|.|.|||.|::|.:.||.|||:..:.
 Frog  1092 PIRLMLRLGAESGAYPCPLMSRRHRKPLFGEIGHTIINLLTDLRNYQYTIPHVDGLLIHMQVGKI 1156

  Fly  1047 TVIIPKYRQQDVIKAINNASDHILAFAGNFSKVADGHLVCMQNINDDRSEMYSYSTQAINIQGQP 1111
            .:.||..|..:::|.|:.:::|:::...:||..||.||||:||.:.      .|.|||.:..|:.
 Frog  1157 CIKIPSRRHNEILKVIHASNEHVISIGASFSLEADSHLVCVQNSDG------IYQTQANSAPGKD 1215

  Fly  1112 RKITGASFFVLNEALKSSSGLSGKCSIVEDGLMVQIMPAKMEEVRQALRNQNDIDIVCGPIDATD 1176
            |::|||||.|.|.|||:|||...|.|||||||||||||..||.:|||||::.|..|.||.||::|
 Frog  1216 REVTGASFVVFNGALKTSSGFLAKSSIVEDGLMVQIMPDMMEALRQALRDKKDFRIPCGKIDSSD 1280

  Fly  1177 DQSEIVSIKWVDNNRDINVGVKSPIDDQPMDGISNMRVLKWASFNYSNTNYAIRLSDIYIIKC-E 1240
            ...| |:|.||:.....|.|:.||||.|.|:||.:.|:.:...|..::..          :|| |
 Frog  1281 STEE-VTICWVETEEKQNKGITSPIDVQSMEGIPSERICQETDFEVNDKT----------VKCTE 1334

  Fly  1241 DWYATNGGNCEEI---TRIAEQLARSASMALLPLLDLLAAAGINKLGLRATLDQDNVGYEAGARG 1302
            .:|..........   ::.|:::|.:.:.||.|.:..|..:|:|::|||.::|.|.|.|.||:||
 Frog  1335 VFYLLRDHEANSAMAHSQFAKEIATACAAALCPHIKTLKNSGMNRIGLRVSMDIDMVEYRAGSRG 1399

  Fly  1303 SKLPPLYMNALDNHLIATLHGESSGIQ-EPIILELIFYI 1340
            ..||.||:|.||..||..:|..:|... .|:::||||::
 Frog  1400 QLLPQLYLNDLDCALIPVIHNRTSDTSILPLVMELIFFL 1438

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sara	NP_524729.2	FYVE_endofin	522..589	CDD:277268	37/66 (56%)
		SARA	614..650	CDD:288292	22/37 (59%)
		DUF3480	959..1321	CDD:288806	160/365 (44%)
zfyve16	XP_012808244.1	FYVE_endofin	679..742	CDD:277268	36/63 (57%)
		SARA	761..799	CDD:371513	22/37 (59%)
		DUF3480	1069..1418	CDD:371829	160/365 (44%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	323	1.000	Domainoid score	I1213
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	566	1.000	Inparanoid score	I1063
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003142
OrthoInspector	1	1.000	-	-		otm48138
Panther	1	1.100	-	-	LDO	PTHR46319
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2534
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.060