DRSC/TRiP Functional Genomics Resources

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Protein Alignment Sara and zfyve9a

DIOPT Version :9

Sequence 1:NP_524729.2 Gene:Sara / 44263 FlyBaseID:FBgn0026369 Length:1343 Species:Drosophila melanogaster
Sequence 2:XP_005171254.1 Gene:zfyve9a / 100005449 ZFINID:ZDB-GENE-070705-182 Length:1216 Species:Danio rerio


Alignment Length:1341 Identity:433/1341 - (32%)
Similarity:639/1341 - (47%) Gaps:306/1341 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   157 HSEELATP-PEDEKTSEVQVEPKEQDQQPEQVKHED-QHQDQAVP-PPTQSKQTVEELAVGLSSI 218
            :.:|..|| ..|.|.:::...|.........:.|.| ..:|..:. .|....||.:    |.|.:
Zfish    22 NEDETDTPILSDAKWTQILAPPSHLLSLNPALTHSDLSPRDSPISFKPLLDTQTSD----GPSLV 82

  Fly   219 SITASGTESQSLLPEEVTASSVLGQVLEELSEE------SSPSREPETEMTNGIDVPLANLP--- 274
            .:|            .:.....|||..|..|||      |.|..:|........|..||:||   
Zfish    83 EVT------------RLNGKQGLGQQQEGKSEERPADVYSPPLPQPNIGKLVSTDGQLADLPSFN 135

  Fly   275 ASVAEVPVPKEMEQPVQTE----EED-----------------VELPQEQHPRRSQP-LTFCSTM 317
            :.|.|...|...:..||::    .:|                 .||..||:...|.. ..|.||.
Zfish   136 SGVLENGYPASPDHTVQSDIIRFNDDETNQPVIDKKCLKDTGPCELKLEQNGHISDAGRDFISTE 200

  Fly   318 DEISD------------TELDSMLQ----------------------------------EMDA-- 334
            :|..|            |..|..:.                                  |:|.  
Zfish   201 EESEDKPSILKNGVKMETSKDESVSPSCKVGIRDNSNGLCPEGSSSHKGVLHKSVNGGGELDCGR 265

  Fly   335 --DDNQADDQQMPDD---EKSCSASPVTEEESVRILSDEQETTSNDQMNVDNFSQASTVEFADLK 394
              |:....:..|.::   ||..|||  .:||..::|..:.:....:.:..:.......||..|  
Zfish   266 ENDEGAFQNGVMVENENTEKDNSAS--NQEEKEKMLKTDHKGMHKESLEGERCLSDGLVEDLD-- 326

  Fly   395 QPESTPVTAMGEDVASSFSSTESDSLSGRKLDGEVEVDREH----------------EDASLATD 443
                      |:.......|::.||::..|   |:|..::.                .::.|...
Zfish   327 ----------GDAQNQLAVSSKEDSVTEEK---EIEESKQETCDPVRQLESGRTGKLNNSRLQPV 378

  Fly   444 ALETQEQRPQRPQTLNL-------NGCQAESSTPSQDENPEIQQET------LQPTEV------- 488
            ::.....||::|..|.|       |..|.|..|.|:::|.|.|..|      .:.||.       
Zfish   379 SIPYGGARPKQPVNLKLQIPQPLSNQVQNEFGTNSKNKNMEPQSRTGGLDASSEATESGVVQING 443

  Fly   489 --REGAAGVGVIPGE--DDEESPIYEAVGYSDPHANLGKVPPIWVPDNMAGQCMQCQQKFTMIKR 549
              ..|::|: :||.|  |::.....:......|.::||:|.|:||||:.|..||:|:.|||..||
Zfish   444 EHGNGSSGL-IIPSESPDNDLQAGQQGAFSKKPLSSLGEVAPVWVPDSQAPICMKCEVKFTFTKR 507

  Fly   550 RHHCRACGKVLCSVCCSQRFRLEFATEPESRVCVQCYMILS-----ERQANGLNSESAPGSALPP 609
            ||||||||||.|:.|||.:.||.:....|:||||.|:..|.     |...:|.|           
Zfish   508 RHHCRACGKVFCAACCSLKSRLMYMDRKEARVCVTCHCALINAQTWENTGSGCN----------- 561

  Fly   610 TPIRSPNPNNPMEYCSTIPPHRQVANSPGA---PPPSVIVPVGVLKKTDGSSSNSSSSDGQKGQ- 670
               :|||||||.||||||||.:| |.:.||   |||:|:|||||||:           .|.:|. 
Zfish   562 ---QSPNPNNPAEYCSTIPPLQQ-AQASGALSSPPPTVMVPVGVLKQ-----------PGSEGSL 611

  Fly   671 -RKRKSVMFSDGIAPGSELASTMEQQWGESKHSRRGLSRSGSGAGQKPPTPATEEPPRSIDTSST 734
             |:::.|.|:|||.|..|                              .|.:::.|..:.:    
Zfish   612 PREQRRVWFADGILPNGE------------------------------ATDSSKAPAANPN---- 642

  Fly   735 LGLVAQLFRGSIPPSAAAATLSATETSAGRSSSQS-----QAQTSPRRKAESSRNRKLPPNGDAQ 794
                         ||...||...:..|:|.::|::     ...|||...:.|             
Zfish   643 -------------PSQPVATSQNSNKSSGANASEAVHGSGALTTSPVGSSFS------------- 681

  Fly   795 GCYLPPEENGLPPICISS----KEGGEV-DYKVVR--NDGSLLDRLQN---ETLKFIIKNNFFVL 849
               |.||: |||||.||:    ..||.: ||.|..  ::.:|:.:|:.   :.|.|::..|...:
Zfish   682 ---LIPED-GLPPILISTGVKGGTGGHITDYAVEERPSEIALMQQLEEGCPDPLVFVLNANLLAM 742

  Fly   850 VKIVNMSCCMNRWVLNFTTSGLHHMGSDELIILLEIKQPKQEEYVKGEVAIPKDLFQHLYEIYVE 914
            ||:||.   :||.....||.|:|.:|..|:::||:.        :..|..||||:|.|..::|.|
Zfish   743 VKLVNY---VNRKCWYMTTKGMHAVGQAEVVVLLQC--------LPDEKTIPKDIFTHFVQLYRE 796

  Fly   915 AEHARSGTH--ELAFTSPRNANFLGSREHGGFIFIRPTYQCLQGVIVPDNPYLVGVLIHRHEVPW 977
            |.......|  ...||.    :||||:|||||:::.||:|.||.:.:|::|||.|:|:.:.|.||
Zfish   797 ALAGNVLGHLGHSFFTQ----SFLGSKEHGGFLYVNPTFQTLQDLPLPNSPYLFGILVQKWETPW 857

  Fly   978 AKVLPLRLILRLGAQYRYYPCPLISVRGRESVYGEIAQTIINFLVDFRNYSYSLPAIRGLYIHME 1042
            |||.|:||:|||||:||:|||||.|||.|:.::||...||:|.|.|||||.|:||.::||.:.||
Zfish   858 AKVFPIRLMLRLGAEYRFYPCPLFSVRFRKPLFGETGHTIMNLLADFRNYQYTLPVVKGLVVDME 922

  Fly  1043 DRQTTVIIPKYRQQDVIKAINNASDHILAFAGNFSKVADGHLVCMQNINDDRSEMYSYSTQAINI 1107
            .|:|.:.||..|..:::||:|.:::|:||....|:..||.||||:|  |||.    :|.||||:|
Zfish   923 VRKTCIKIPSNRYNELMKAMNKSNEHVLAMGACFNDRADSHLVCVQ--NDDG----NYQTQAISI 981

  Fly  1108 QGQPRKITGASFFVLNEALKSSSGLSGKCSIVEDGLMVQIMPAKMEEVRQALRNQNDIDIVCGPI 1172
            ..||||:|||||||.:.|||:|||...|.||||||:||||....||.:|||||...|..|.||..
Zfish   982 HHQPRKVTGASFFVFSGALKASSGYLAKTSIVEDGVMVQITAETMEALRQALREMKDFSIACGKA 1046

  Fly  1173 DATDDQSEIVSIKWVDNNRDINVGVKSPIDDQPMDGISNMRVLKWASFNYSNTNYAIRLSDIYII 1237
            |..::| |.|.::|||::.::|.||.||||.:.|:.::::::...:  .|......|:.::::.:
Zfish  1047 DQEENQ-EHVQVQWVDDDHNVNKGVISPIDGKSMESVTSVKIFHGS--EYKANGKVIKWTEVFFL 1108

  Fly  1238 KCEDWYATNG-GNCEEITRIAEQLARSASMALLPLLDLLAAAGINKLGLRATLDQDNVGYEAGAR 1301
            :.||  ..|| .:..:.:|:||.:||:..|||.|.|.||...|:.|||||.|||.|.|||.||:.
Zfish  1109 RSED--QNNGLSDPADHSRLAENVARAFCMALCPHLKLLKEDGMAKLGLRVTLDSDQVGYLAGSN 1171

  Fly  1302 GSKLPPLYMNALDNHLIATLHGESSGIQE-PIILELIFYIL 1341
            |..|.|.|::.||:.||..:|..:..:.| |:::|||||||
Zfish  1172 GQPLLPQYLSELDSALIPVIHSGACQLSEGPVVMELIFYIL 1212

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SaraNP_524729.2 FYVE_endofin 522..589 CDD:277268 38/66 (58%)
SARA 614..650 CDD:288292 26/38 (68%)
DUF3480 959..1321 CDD:288806 172/362 (48%)
zfyve9aXP_005171254.1 FYVE_endofin 480..547 CDD:277268 38/66 (58%)
SARA 563..601 CDD:288292 26/38 (68%)
DUF3480 839..1191 CDD:288806 172/362 (48%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170594742
Domainoid 1 1.000 331 1.000 Domainoid score I1127
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 562 1.000 Inparanoid score I1052
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0003142
OrthoInspector 1 1.000 - - otm25590
orthoMCL 1 0.900 - - OOG6_105532
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2928
SonicParanoid 1 1.000 - - X2534
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
109.820

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