Protein Alignment eIF5B and IFM1

DIOPT Version :10

• Sequence 1: NP_651974.1
• Gene: eIF5B / 44261
• FlyBaseID: FBgn0026259
• Length: 1144
• Species: Drosophila melanogaster
• Sequence 2: NP_014619.1
• Gene: IFM1 / 854135
• SGDID: S000005383
• Length: 676
• Species: Saccharomyces cerevisiae
• Alignment Length: 577
• Identity: 141/577 - (24%)
• Similarity: 248/577 - (42%)
• Gaps: 124/577 - (21%)

  Fly   554 RAGVVCVLGHVDTGKTKILDKLRRTHVQDSEAGGITQQIGATNVPIEAIKEQTKYVKAAAGFEHR 618
            ||.||.::||||.|||.|:|.||::.|...|.|||||.|||  ..|.|.|...|
Yeast   144 RAPVVTIMGHVDHGKTTIIDYLRKSSVVAQEHGGITQHIGA--FQITAPKSGKK----------- 195

  Fly   619 LPGLLIIDTPGHESFSNLRNRGSSLCDIAILVVDIMHGLEPQTIESIQLLKKKKCPFIVALNKID 683
               :..:|||||.:|..:|.||:::.||.:|||.:...|.|||:|:|:..|......|:|:.|||
Yeast   196 ---ITFLDTPGHAAFLKMRERGANITDIIVLVVSVEDSLMPQTLEAIKHAKNSGNEMIIAITKID 257

  Fly   684 RLYDWKQLARRDVRDVLKEQQSNTQLEFQQRTKDVILQFAEQGLNAALFYENTDPKTYISLVPTS 748
            |:...|                    |.:::.:.||.....||:.......:      :.::|.|
Yeast   258 RIPQPK--------------------EREKKIEKVINDLIVQGIPVEKIGGD------VQVIPIS 296

  Fly   749 AISGEGMGNLLFMIADFCQNMLAKRLMYSEEL-------------QATVLEVKALPGLGTTIDAI 800
            |.:||.|            ::|.:.::...|:             :..::|.:....:|.....:
Yeast   297 AKTGENM------------DLLEESIVLLSEVMDIRAENSPKTIAEGWIIESQVKKQVGNVATVL 349

  Fly   801 LINGKLREGQTMVVAGTDGPIVTQIRSLLMPQPMKELRVKNAY----VEYKEVKAAQGVKIAAKD 861
            :..|.|::|:.::...|    ..:|::|:..:.:..|:...:|    :.:|:|.......|..|
Yeast   350 VKKGTLQKGKILICGNT----FCKIKNLIDDKGIPILKATPSYATEVLGWKDVPHVGDEVIQVK- 409

  Fly   862 LEKAIAGINLLIAHKPDEVEI---------CTEE--VARE--LKSALSHIKLAQ-----TGVH-- 906
             .:|||  ...|:.:.|.:|:         ..||  :|:|  |...|.|....|     ||..
Yeast   410 -SEAIA--KKFISKRQDLIEVQKNSSIVEKLNEERALAKEQHLNKELEHENTVQEHEQNTGPKLI 471

  Fly   907 ---VQASTLGSLEALLEFLRTSKIPYSAIR-------IGPVVKRDVMKASTMLEHEAQYATILAF 961
               ::....||.||:.|.:  |.:....:|       :|...:.| :|.:.:.|     :|||.|
Yeast   472 NYIIKCDVSGSAEAVSESI--SSLGNDEVRCNVISSSVGIPTESD-LKMAQITE-----STILCF 528

  Fly   962 DVKIEREAQEMADSLGVKIFQADIIYHLFDKFTAYREELKQKKREEFRSVAVFPCKLRILPQFVF 1026
            ::. ...::.:.:..|:||.|.::||.|.:..|   |.|.:..:..|....|....:|....|..
Yeast   529 NLG-NLPSEVINNRAGIKIKQYNVIYKLIEDVT---ETLTENLKPIFEKKIVSTVDVRETFDFRL 589

  Fly  1027 NSRDPIVMGVMVENGIVKVGTPICV---PSKEFVDIGIVTSIESNHKQIEFARKGQE 1080
            ..:...:.|..|.||::|..:.:.|   |:::.:..|.:::::.|...:....||.|
Yeast   590 KKKIIRIAGCKVNNGVIKKNSLVQVVRGPNEDVIFDGKISTLKHNKDDVAEVSKGHE 646

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eIF5B	NP_651974.1	PRK04004	553..1129	CDD:457675	141/577 (24%)
IFM1	NP_014619.1	IF2_N	63..114	CDD:428110
		InfB	143..676	CDD:440298	141/577 (24%)