Protein Alignment eIF5B and FUN12

DIOPT Version :10

• Sequence 1: NP_651974.1
• Gene: eIF5B / 44261
• FlyBaseID: FBgn0026259
• Length: 1144
• Species: Drosophila melanogaster
• Sequence 2: NP_009365.1
• Gene: FUN12 / 851196
• SGDID: S000000033
• Length: 1002
• Species: Saccharomyces cerevisiae
• Alignment Length: 1092
• Identity: 453/1092 - (41%)
• Similarity: 657/1092 - (60%)
• Gaps: 128/1092 - (11%)

  Fly    87 KASKKSAFELLMDDDEQDEPAAQESQSEKEEKVVVSKPQKNEKKGKKAKRKGKDDDDEDLDKVLA 151
            |.|||:.....  |:|.:|.|||..:       :.:.|..|.:..     .|.||...
Yeast     3 KKSKKNQQNYW--DEEFEEDAAQNEE-------ISATPTPNPESS-----AGADDTSR------- 46

  Fly   152 ELQAEYAGEAAPAATTVVSPEELADEFSKKKKNKKQAKQAAVAENAGEDEASDDEEGGSTVKSAA 216
              :|..:.|.|.|..        .|..|..|::||:.::..:.|.         ::|...:||..
Yeast    47 --EASASAEGAEAIE--------GDFMSTLKQSKKKQEKKVIEEK---------KDGKPILKSKK 92

  Fly   217 QKKKEK--KERQKREAALAKQKA---ATEPKPKPVEKPAPEPEPVATEEVQPAAEEEEEKSSKNK 276
            :|:|||  ||:||::...|::||   |.:.|.|.:.|          :.|:.||.|:.......|
Yeast    93 EKEKEKKEKEKQKKKEQAARKKAQQQAQKEKNKELNK----------QNVEKAAAEKAAAEKSQK 147

  Fly   277 KKGKKDKKAEPEEEKKDAKKKGMSASMVAAMQE-QLRKRKEEEERLEREEAERIRLEDEREEARL 340
            .||:.||.:  ...||.|||  :.|.:.|..:: :|:|:.||:|:|||||.|  |||.|.||...
Yeast   148 SKGESDKPS--ASAKKPAKK--VPAGLAALRRQLELKKQLEEQEKLEREEEE--RLEKEEEERLA 206

  Fly   341 EAVRLEAERKEKKKQREAERKARLKAEGKLLTKKQKEDR----ARAQALLES--LKAQGLEIPDP 399
            ...:::.|.|..||::|..::.:.||||||||:||||::    .|..|||.|  :|..||...|.
Yeast   207 NEEKMKEEAKAAKKEKEKAKREKRKAEGKLLTRKQKEEKKLLERRRAALLSSGNVKVAGLAKKDG 271

  Fly   400 NDKRPTRPGTRIRPNKKKGPKEEAAEEEAKAAEAEAQSAAAAAAAAAAEKAEEERVKES------ 458
            .:.:|.:.   :...|||...:|.|.|..| ::::..|          |...::.:|||
Yeast   272 EENKPKKV---VYSKKKKRTTQENASEAIK-SDSKKDS----------EVVPDDELKESEDVLID 322

  Fly   459 -WD--ATDSEAEPEPEEETSQATNNGKTEAAEEENEDTDDDEDDDDDEDDSDDSDGDSDDSREVS 520
             |:  |...:.|....|||.::|       |..||||.:..|::::.|::.::   :.:.:....
Yeast   323 DWENLALGDDDEEGTNEETQEST-------ASHENEDQNQGEEEEEGEEEEEE---EEERAHVHE 377

  Fly   521 VLANDPESRRLRAEARILKRQAEAEKKRSTDELRAGVVCVLGHVDTGKTKILDKLRRTHVQDSEA 585
            |..:.|.:   ...|......|...||    :||:.:.|:||||||||||:|||:|:|:||..||
Yeast   378 VAKSTPAA---TPAATPTPSSASPNKK----DLRSPICCILGHVDTGKTKLLDKIRQTNVQGGEA 435

  Fly   586 GGITQQIGATNVPIEAIKEQTKYVKAAAGFEHR---LPGLLIIDTPGHESFSNLRNRGSSLCDIA 647
            ||||||||||..||:|||.:||.:   |.:|.:   :||||:|||||||||||||:||||||:||
Yeast   436 GGITQQIGATYFPIDAIKAKTKVM---AEYEKQTFDVPGLLVIDTPGHESFSNLRSRGSSLCNIA 497

  Fly   648 ILVVDIMHGLEPQTIESIQLLKKKKCPFIVALNKIDRLYDWKQLARRDVRDVLKEQQSNTQLEFQ 712
            |||:|||||||.||||||:||:.:|.||:|||||||||||||.:.....||...:|....|.|||
Yeast   498 ILVIDIMHGLEQQTIESIKLLRDRKAPFVVALNKIDRLYDWKAIPNNSFRDSFAKQSRAVQEEFQ 562

  Fly   713 QRTKDVILQFAEQGLNAALFYENTDPKTYISLVPTSAISGEGMGNLLFMIADFCQNMLAKRLMYS 777
            .|...:.|:.||||||:.|:::|.:...|:|:|||||::|||:.:||:::.:..|..::|:|||.
Yeast   563 SRYSKIQLELAEQGLNSELYFQNKNMSKYVSIVPTSAVTGEGVPDLLWLLLELTQKRMSKQLMYL 627

  Fly   778 EELQATVLEVKALPGLGTTIDAILINGKLREGQTMVVAGTDGPIVTQIRSLLMPQPMKELRVKNA 842
            ..::||:||||.:.|.|||||.||.||.||||..:|:.|.:|||||.||:||.|||::|||:|:.
Yeast   628 SHVEATILEVKVVEGFGTTIDVILSNGYLREGDRIVLCGMNGPIVTNIRALLTPQPLRELRLKSE 692

  Fly   843 YVEYKEVKAAQGVKIAAKDLEKAIAGINLLIAHKPDEVEICTEEVARELKSALSHIKLAQTGVHV 907
            ||.:||||||.||||||.|||||::|..||:....|:.:...::|..:|...|..:.....||.|
Yeast   693 YVHHKEVKAALGVKIAANDLEKAVSGSRLLVVGPEDDEDELMDDVMDDLTGLLDSVDTTGKGVVV 757

  Fly   908 QASTLGSLEALLEFLRTSKIPYSAIRIGPVVKRDVMKASTMLEHEAQYATILAFDVKIEREAQEM 972
            ||||||||||||:||:..|||..:|.:|||.||||||||||||...:||.:|.||||:::||::.
Yeast   758 QASTLGSLEALLDFLKDMKIPVMSIGLGPVYKRDVMKASTMLEKAPEYAVMLCFDVKVDKEAEQY 822

  Fly   973 ADSLGVKIFQADIIYHLFDKFTAYREELKQKKREEFRSVAVFPCKLRILPQFVFNSRDPIVMGVM 1037
            |:..|:|||.||:||||||.||||:|:|.:::|::|...|:|||.|:.|.  :.|.|.|:::||.
Yeast   823 AEQEGIKIFNADVIYHLFDSFTAYQEKLLEERRKDFLDYAIFPCVLQTLQ--IINKRGPMIIGVD 885

  Fly  1038 VENGIVKVGTPIC-------VPSKEFVDIGIVTSIESNHKQIEFARKGQE---ICVKIDPIPGES 1092
            |..|.::||||||       ...::.:.:|.|.|:|.||:.::..:|||.   :.|:::...|:.
Yeast   886 VLEGTLRVGTPICAVKTDPTTKERQTLILGKVISLEINHQPVQEVKKGQTAAGVAVRLEDPSGQQ 950

  Fly  1093 PKMFGRHFEADDMLISKISRQSIDACKD-YFRDDLIKADWALMVELKKLFEI 1143
            | ::|||.:.:|.|.|.:||:|||..|| .|||.:.::||.|:.:||.:|.|
Yeast   951 P-IWGRHVDENDTLYSLVSRRSIDTLKDKAFRDQVARSDWLLLKKLKVVFGI 1001

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eIF5B	NP_651974.1	PRK04004	553..1129	CDD:457675	311/589 (53%)
FUN12	NP_009365.1	PRK04004	400..964	CDD:457675	301/573 (53%)