DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment eIF5B and CG4849

DIOPT Version :9

Sequence 1:	NP_001246599.1	Gene:	eIF5B / 44261	FlyBaseID:	FBgn0026259	Length:	1144	Species:	Drosophila melanogaster
Sequence 2:	NP_651605.1	Gene:	CG4849 / 43358	FlyBaseID:	FBgn0039566	Length:	975	Species:	Drosophila melanogaster

Alignment Length:	703	Identity:	145/703 - (20%)
Similarity:	260/703 - (36%)	Gaps:	208/703 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   486 AEEENEDT----DDDEDDDDDEDDSDDSDGDSDDSREVS--VLAND------------------- 525
            ::||:|.:    .|.:||.:|..|.|:.:...|:.:||:  ||..|
  Fly    19 SDEEDEQSIYGQPDVQDDPEDAMDEDEVEPQEDEDKEVTAVVLHEDKRYYPSAVEVYGPDVETIV 83

  Fly   526 ------PESRRLRAEARILKRQAEAEKKRSTD---ELRAGV---------VCVLGHVDTGKTKIL 572
                  |..:.|....:.||.|.:.:..:.|.   |..|.:         |.::||:..|||..:
  Fly    84 QEEDAQPLDKPLIEPVKKLKFQIKEQDMQETTYDMEFMADLMDTPPLIRNVALVGHLHHGKTTFV 148

  Fly   573 DKL-RRTHVQ-----------------DSEAGGITQQIGATNVP--IEAIKEQTKYVKAAAGFEH 617
            |.| |:||.|                 :.|.|   ..|.||.|.  ::.:| |..|:
  Fly   149 DCLIRQTHPQFETMEERQLRYTDTLFTEQERG---CSIKATPVTLVLQDVK-QKSYL-------- 201

  Fly   618 RLPGLLIIDTPGHESFSNLRNRGSSLCDIAILVVDIMHGLEPQTIESIQLLKKKKCPFIVALNKI 682
                |.|.|||||.:||:.......:.|..:|.:|...|:...|...::...:::....|.:|||
  Fly   202 ----LNIFDTPGHVNFSDEATAAMRMSDGVVLFIDAAEGVMLNTERLLKHAVQERQAITVCINKI 262

  Fly   683 DRLYDWKQLARRDVRDVLKEQQSNTQLEFQQRTKDVI--LQFAEQGLNAAL-FYENTDPKTYISL 744
            |||.                      ||.:...:|..  |:...:.:|..| .|...|....:|.
  Fly   263 DRLI----------------------LELKLPPQDAYFKLKHIVEEVNGLLSTYGAPDDNLLVSP 305

  Fly   745 VPTSAISGEGMGNLLF--MIADFCQNMLAKRLMYSEELQATV-LE-VKALPGLGTTIDAILINGK 805
            :         :||:.|  .:..||..:.:...:|::..:... |: .|.|.|      .:..|.|
  Fly   306 I---------LGNVCFASSLYGFCFTLKSFAKLYADTYEGVAYLDFAKRLWG------DMYFNSK 355

  Fly   806 LREGQTMVVAGTDGPIVTQIRSLL--MPQPMKEL---RVKNAYVEYKEVKAAQGVKIAAKDLEKA 865
            .|:      .....|..:..||.:  :.:||.:|   .|.:......:..|...|:::.::::..
  Fly   356 TRK------FSKKQPHNSAQRSFVEFILEPMYKLIAQVVGDVDTTLSDTLAELNVRVSKEEMKSN 414

  Fly   866 IAGINLLIAHK-----PDEVEICTEEVARELKSALSHIKLAQTGVH--------VQASTLGSLEA 917
            |..:..|:.::     ...|::|.|.:...|::|...:....||..        :..:..|:|
  Fly   415 IRPLLRLVCNRFMGDCSGFVDMCVEHIKSPLENAKRKVDHIYTGPKEGDIYRDMISCNQYGTL-- 477

  Fly   918 LLEFLRTSKI-PYSAIRIGPVVKRDVMKASTMLEHEAQYATILAFDVKIEREAQEMADSLGVKIF 981
               .:.:||: |........|:.|.|  :.|:  |..|       :|::..|...:.|....:|.
  Fly   478 ---MVHSSKMYPNDDCTFFQVLARIV--SGTL--HAGQ-------EVRVLGENYTLQDEEDSRIL 528

  Fly   982 QADIIYHLFDKFTAYREELKQKKREEFRSVAVFPCKLRILPQFVFNSRDPIVMGVMVE---NGIV 1043
            |...:: :|:  :.|:.||                           :|.|....|::|   ..||
  Fly   529 QVGRLW-VFE--SRYKVEL---------------------------NRVPAGNWVLIEGIDQCIV 563

  Fly  1044 KVGTPICVPSKEFVDIGIVTSIESNHKQIEFARKGQEICVKIDPI-PGESPKM 1095
            |..|.:.:...|  |:.|...::.|.:.|        |.:.::|: |.|.|||
  Fly   564 KTSTIVDINVPE--DLYIFRPLKFNTQSI--------IKIAVEPVNPSELPKM 606

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF5B	NP_001246599.1	PRK04004	553..1129	CDD:235195	123/602 (20%)
		IF2_eIF5B	557..769	CDD:206674	56/245 (23%)
		aeIF5B_II	779..889	CDD:293904	21/121 (17%)
		IF-2	890..993	CDD:288813	21/111 (19%)
		IF2_aeIF5B_IV	1016..1110	CDD:293911	20/84 (24%)
CG4849	NP_651605.1	EFTUD2	4..111	CDD:292623	20/91 (22%)
		PTZ00416	115..957	CDD:240409	124/607 (20%)
		Snu114p	132..340	CDD:206730	57/254 (22%)
		Translation_Factor_II_like	477..568	CDD:295476	26/136 (19%)
		snRNP_III	589..660	CDD:293921	8/26 (31%)
		EF2_IV_snRNP	660..837	CDD:238840
		eEF2_C_snRNP	832..911	CDD:239765
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45464566
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930