Protein Alignment eIF5B and mRRF2

DIOPT Version :9

• Sequence 1: NP_001246599.1
• Gene: eIF5B / 44261
• FlyBaseID: FBgn0026259
• Length: 1144
• Species: Drosophila melanogaster
• Sequence 2: NP_732771.2
• Gene: mRRF2 / 42670
• FlyBaseID: FBgn0051159
• Length: 740
• Species: Drosophila melanogaster
• Alignment Length: 625
• Identity: 129/625 - (20%)
• Similarity: 241/625 - (38%)
• Gaps: 149/625 - (23%)

  Fly   546 KKRSTDELRAGVVCVLGHVDTGKTKILDKLRRTHVQDSEAGGITQQIGAT---NVPIEAIKEQTK 607
            |:..:.::|.  :.:|.|:|.|||...:::       ....|.|:.:|..   |...:.:.::.:
  Fly    26 KRSYSSKIRN--IGILAHIDAGKTTTTERM-------LFYAGKTRALGEVHRGNTVTDYLTQERE 81

  Fly   608 ----YVKAAAGF---EHRLPGLLIIDTPGHESFSNLRNRGSSLCDIAILVVDIMHGLEPQTIESI 665
                ...:|..|   :||:.   ::|||||..|:....:.....|..::|:|...|:|.||:...
  Fly    82 RGITICSSAVTFSWNDHRIN---LLDTPGHIDFTMEVEQSLYAVDGVVVVLDGTAGVEAQTVTVW 143

  Fly   666 QLLKKKKCPFIVALNKIDRL-YDWKQLARRDVRDVLKEQQSNTQLEFQQRTKDVILQFAEQGLNA 729
            ....|.|.|.::.:||:||. .|:::.. .|::|.|:.|.  ..|::..:.:|.:|...:.....
  Fly   144 SQADKHKLPRLIFVNKMDRPDADFEKCV-SDLKDKLETQP--VCLQYPVKNEDGVLAINDVITLE 205

  Fly   730 ALFYENTD-PKTY--ISLVPTSAISGEGMGNLLFMIADFCQNMLAKRLM-YSEELQATVLEVKAL 790
            .|.::..| .::|  :.|.|:..:          .:....:|.|..:|. ..:||...|:..::.
  Fly   206 RLSWQQKDLGRSYRNVKLEPSDDL----------RLLQEKRNELIDQLSGLDDELADVVISTESF 260

  Fly   791 PGLGTTIDAILINGKLREGQTMVVAGTDGPIVTQIRSLLMPQPMKELRVK------NAYV----E 845
                ..:|..||...||...|.          .::..:|:....|.:.::      |||:    |
  Fly   261 ----DNVDNALIERALRRATTQ----------QKVVPVLLGSAYKNVGIQRLMDAVNAYLPAPEE 311

  Fly   846 YKEVKAAQGVKIAAKDLEKAIAGINLLIAHKPDEVEICTEEVAR-ELKSALSHIKLAQTGVHVQA 909
            ..::....|.::|.|..:         |.|......:....:.| |:|..:..|     ....||
  Fly   312 RNQIYDCFGTEVAGKVFK---------IVHDKQRGPLTLVRILRGEIKRGMRLI-----SARGQA 362

  Fly   910 STLGSL-EALLEFLRTSKIPYSAIRIGPV---------VKRDVMKASTMLEHEAQ--YATIL--- 959
            ..:..| |.|.:..|    ..||::.|.|         |..|::.:|......||  |...|
  Fly   363 EVVSKLYEPLADEYR----EVSAVQSGDVVICAGLKSTVTGDLLTSSQSALKNAQKRYKQSLGNT 423

  Fly   960 AFDVKIEREAQEMADSLGVKIFQADIIYHL------FDKFTAYREELKQKKREEFRSVAVFPCKL 1018
            |..|:.:.|..|..:...:.....|.:|..      ....||..:.|||.:||:       | .|
  Fly   424 AAKVEEDDELDESDELFAIDPQIPDAVYFCSIEPPSVSSQTAMEQALKQLQRED-------P-SL 480

  Fly  1019 RILPQFVFNSRDPI----VMGVMVE--NGIVK------------VGTPICVPSKEFVDIGIVTSI 1065
            |:       |.|.:    |:|.|.|  ..|:|            :| |:.:..||.::...:|::
  Fly   481 RV-------SYDSVTGQTVLGGMGELHMDIIKSRILSEYKIDVDLG-PLQIAYKETIEAPALTTL 537

  Fly  1066 ESNHKQIEFARKGQEICVKI----------DPIPGESPKM 1095
             |..|:|..:::...|.:::          |..|...|.:
  Fly   538 -SVEKEIAGSKQSVSITLEVVKNQAELFSLDKSPDNLPNL 576

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eIF5B	NP_001246599.1	PRK04004	553..1129	CDD:235195	128/618 (21%)
		IF2_eIF5B	557..769	CDD:206674	47/225 (21%)
		aeIF5B_II	779..889	CDD:293904	20/119 (17%)
		IF-2	890..993	CDD:288813	26/123 (21%)
		IF2_aeIF5B_IV	1016..1110	CDD:293911	22/108 (20%)
mRRF2	NP_732771.2	PRK12739	31..733	CDD:237185	128/620 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45464608
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930