DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eIF5B and eIF2gamma

DIOPT Version :9

Sequence 1:	NP_001246599.1	Gene:	eIF5B / 44261	FlyBaseID:	FBgn0026259	Length:	1144	Species:	Drosophila melanogaster
Sequence 2:	NP_001262587.1	Gene:	eIF2gamma / 41843	FlyBaseID:	FBgn0263740	Length:	475	Species:	Drosophila melanogaster

Alignment Length:	472	Identity:	103/472 - (21%)
Similarity:	167/472 - (35%)	Gaps:	148/472 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   522 LANDPESRRLRAEARILKRQAEAEKKRSTDELRAGVVCVLGHVDTGKT---KILDKLRRTHVQDS 583
            |:|...|:.......::.|||...            :..:|||..||:   |.:..::....::.
  Fly    19 LSNLDVSKLTPLSPEVISRQATIN------------IGTIGHVAHGKSTVVKAISGVQTVRFKNE 71

  Fly   584 EAGGITQQIGATNVPI-----EAIKEQTKYVKAAAGFEHRLP--------------GLLIIDTPG 629
            ....||.::|..|..|     ........:|..|:..:..||              .:..:|.||
  Fly    72 LERNITIKLGYANAKIYKCDNPKCPRPASFVSDASSKDDSLPCTRLNCSGNFRLVRHVSFVDCPG 136

  Fly   630 HESFSNLRNRGSSLCDIAILVVDIMHGLE----PQTIE---SIQLLKKKKCPFIVALNKIDRLYD 687
            |:........|:::.|.|:|::   .|.|    |||.|   :|:::|.|:  .::..|||
  Fly   137 HDILMATMLNGAAVMDAALLLI---AGNESCPQPQTSEHLAAIEIMKLKQ--ILILQNKI----- 191

  Fly   688 WKQLARRDVRDVLKEQQSNTQLEFQQRTKDVILQFAEQGLNAALFYENTDPKTYISLVPTSAISG 752
                      |::||.|:..|  :::.||.|....||..                .::|.||
  Fly   192 ----------DLIKESQAKEQ--YEEITKFVQGTVAEGA----------------PIIPISA--- 225

  Fly   753 EGMGNLLFMIADFCQNMLAK------------RLMY--SEELQATVLEVKALPGLGTTIDAILIN 803
                .|.:.|...|:.::.|            ||:.  |.::.....||..|.| |....:|| :
  Fly   226 ----QLKYNIDVLCEYIVNKIPVPPRDFNAPPRLIVIRSFDVNKPGCEVADLKG-GVAGGSIL-S 284

  Fly   804 GKLREGQT------MVVAGTDG-----PIVTQIRSLLMPQPMKELRVKNAYVEYKEVKAAQGVKI 857
            |.|:.||.      :|...:||     ||.::|.||...|...:..|....:       ..|.||
  Fly   285 GVLKVGQEIEVRPGVVTKDSDGNITCRPIFSRIVSLFAEQNELQYAVPGGLI-------GVGTKI 342

  Fly   858 -----AAKDLEKAIAGINLLIAHKPD---EVEIC--------------TEEVARELKSALSHIKL 900
                 .|..|...:.|   .:...||   |:||.              .::.||..|...:.|.|
  Fly   343 DPTLCRADRLVGQVLG---AVGQLPDIYQELEISYYLLRRLLGVRTDGDKKGARVEKLQKNEILL 404

  Fly   901 AQTGVHVQASTLGSLEA 917
            ...|   ..||.|.:.|
  Fly   405 VNIG---SLSTGGRISA 418

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF5B	NP_001246599.1	PRK04004	553..1129	CDD:235195	97/441 (22%)
		IF2_eIF5B	557..769	CDD:206674	51/240 (21%)
		aeIF5B_II	779..889	CDD:293904	32/142 (23%)
		IF-2	890..993	CDD:288813	8/28 (29%)
		IF2_aeIF5B_IV	1016..1110	CDD:293911
eIF2gamma	NP_001262587.1	PTZ00327	11..465	CDD:240362	103/472 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45464581
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930