DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eIF5B and CG33158

DIOPT Version :9

Sequence 1:	NP_001246599.1	Gene:	eIF5B / 44261	FlyBaseID:	FBgn0026259	Length:	1144	Species:	Drosophila melanogaster
Sequence 2:	NP_788515.1	Gene:	CG33158 / 39834	FlyBaseID:	FBgn0053158	Length:	1033	Species:	Drosophila melanogaster

Alignment Length:	625	Identity:	141/625 - (22%)
Similarity:	234/625 - (37%)	Gaps:	211/625 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   558 VCVLGHVDTGKTKILD---------------KLR-RTHVQDSEAGGITQQIGATNVPIEAIKEQT 606
            :|:|.|||.|||.:.|               ||| ..:..|.:..|||.:..:.::..:..:|.
  Fly    22 ICILAHVDHGKTTLADSLVASNGIISQRMAGKLRYLDNRSDEQERGITMKSSSISLYYQEAEEM- 85

  Fly   607 KYVKAAAGFEHRLPGLLI--IDTPGHESFSNLRNRGSSLCDIAILVVDIMHGLEPQTIESIQLLK 669
                  ||    .|..||  ||:|||..||:..:....|||.||:|||::.|:.|||...::.:.
  Fly    86 ------AG----NPDYLINLIDSPGHVDFSSEVSTAVRLCDGAIVVVDVVEGVGPQTRACLRQIY 140

  Fly   670 KKKCPFIVALNKIDRLYDWKQLARRD----VRDVLKEQQSNTQLEFQQRTKDVILQFAEQGLNAA 730
            :::...::.|||:|||...||:...|    :..||::..:.....|   ..|::   |::.:...
  Fly   141 EEQLKPVLVLNKLDRLILEKQMDPLDAYFHLCQVLEQVNAVLGSIF---ASDIL---AKEDITKK 199

  Fly   731 LFYENT-----DPKTYISLVPTSAISGEGMGNLL---------FMIADFCQNMLAKRLMYSEELQ 781
            ..||:.     |.:.|.|  |:|       ||::         |.:.||.. |.||||..|.:..
  Fly   200 DNYESALEEVDDSELYFS--PSS-------GNVIFCSAYDGWAFSVRDFAA-MYAKRLEMSRKDL 254

  Fly   782 ATVL---------EVKALPGLGTTIDAILINGKLREGQTMVVAGTDGPIVTQIRSLLMPQPMKEL 837
            ..||         :.:||||           .:.:..:.|.|..    ::..|.||     ...:
  Fly   255 ENVLWGDFYYNSKKKEALPG-----------AQEKAKKPMFVQF----VLENIWSL-----YDII 299

  Fly   838 RVKNAYVEYKEVKAAQGVKIAAKDLE--------KAIAG---------INLLIAHKPDEVEICTE 885
            .::....:...:....|:|:|.:||.        ||:.|         ::::|.|.|...:|..|
  Fly   300 AIRKDKDKLPGIAEKLGLKLATRDLRLTDPKLQIKAVLGQWLPIDKSVLHMVIQHVPPPHKISDE 364

  Fly   886 EVARELKSALSHIKLAQTGVHVQASTL--GSLEALLEFLRTSKIPYSAIRIGPVVKRDVMKASTM 948
            ...|.|..|           :|..|:|  .:||....|  ||....|:..|..|.|...:..:.:
  Fly   365 RAQRLLYPA-----------NVDLSSLPPETLELKESF--TSCDANSSNVIAFVSKMTPVHITHL 416

  Fly   949 LEHEAQYATILAFDVKIEREAQEMADSLGVKIFQADIIYHLFDKFTAYREELKQKKRE-EFRSVA 1012
            .::..:..|        ::|.|:..|.:..:|                 ||.||:..: |...::
  Fly   417 PQNRPKRLT--------DQEVQQRRDEVRRRI-----------------EERKQQSEQAELEKIS 456

  Fly  1013 VFPCKLRILPQFVFNSRDPIVMGVMVENGIVKVGTPICVPSKEFVDIGIVTSIESNHKQ------ 1071
                                       .|:.::.|.:..|.||          ||..::
  Fly   457 ---------------------------QGVEQLSTQVVGPEKE----------ESKPEEADQNEF 484

  Fly  1072 --IEFAR-------KGQE---ICVKIDP------IPGESP 1093
              |.|||       :|.|   :..|.||      ..||:|
  Fly   485 VFIAFARVFSGTLKRGMELFNLSPKHDPRQPTHRKEGEAP 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF5B	NP_001246599.1	PRK04004	553..1129	CDD:235195	141/625 (23%)
		IF2_eIF5B	557..769	CDD:206674	67/246 (27%)
		aeIF5B_II	779..889	CDD:293904	24/135 (18%)
		IF-2	890..993	CDD:288813	19/104 (18%)
		IF2_aeIF5B_IV	1016..1110	CDD:293911	19/102 (19%)
CG33158	NP_788515.1	PTZ00416	15..1016	CDD:240409	141/625 (23%)
		EF2	20..249	CDD:206672	72/253 (28%)
		EF2_II	485..572	CDD:293913	12/40 (30%)
		EF2_snRNP_III	587..658	CDD:293918
		aeEF2_snRNP_like_IV	658..899	CDD:238839
		eEF2_snRNP_like_C	896..974	CDD:239763
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45464649
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930