Protein Alignment eIF5B and eEF2

DIOPT Version :10

• Sequence 1: NP_651974.1
• Gene: eIF5B / 44261
• FlyBaseID: FBgn0026259
• Length: 1144
• Species: Drosophila melanogaster
• Sequence 2: NP_525105.2
• Gene: eEF2 / 35422
• FlyBaseID: FBgn0000559
• Length: 844
• Species: Drosophila melanogaster
• Alignment Length: 641
• Identity: 130/641 - (20%)
• Similarity: 232/641 - (36%)
• Gaps: 198/641 - (30%)

  Fly   545 EKKRSTDELRAGVVCVLGHVDTGKTKILDKL---------------RRTHV-QDSEAGGITQQIG 593
            :|||:...:     .|:.|||.||:.:.|.|               |.|.. :|.:...||.:..
  Fly    14 DKKRNIRNM-----SVIAHVDHGKSTLTDSLVSKAGIIAGAKAGETRFTDTRKDEQERCITIKST 73

  Fly   594 ATNVPIEAIKEQTKYVKAAAGFEHRLPGLLI--IDTPGHESFSNLRNRGSSLCDIAILVVDIMHG 656
            |.::..|..::...::......|....|.||  ||:|||..||:.......:.|.|::|||.:.|
  Fly    74 AISMYFEVEEKDLVFITHPDQREKECKGFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDCVSG 138

  Fly   657 LEPQTIESI--QLLKKKKCPFIVALNKIDRLYDWKQLARRDVRDVLKEQQSNTQLEFQQRTKDVI 719
            :..|| |::  |.:.::..| |:.:||:||              .|.|.|.:.: |..|..:.::
  Fly   139 VCVQT-ETVLRQAIAERIKP-ILFMNKMDR--------------ALLELQLDAE-ELYQTFQRIV 186

  Fly   720 LQFAEQGLNAALFYENTD--PKTYISLVPT--SAISGEGMGNLLFMIADFCQNMLAKRLMYSEEL 780
                 :.:|..:...|.|  |...:.:.|:  |...|.|:....|.:..|.:       ||||:.
  Fly   187 -----ENVNVIIATYNDDGGPMGEVRVDPSKGSVGFGSGLHGWAFTLKQFSE-------MYSEKF 239

  Fly   781 QATVLEVKALPGLGTTIDAILINGKLREGQTMVVAGTDGPIVTQIRSLLMPQPMKELRVKNAYVE 845
            :               ||.:.:..:| .|:....|.|.           ..|..||...|.::..
  Fly   240 K---------------IDVVKLMNRL-WGENFFNAKTK-----------KWQKQKEADNKRSFCM 277

  Fly   846 YKEVKAAQGVKIAAKDLEKAIAGINLLIAHKPDEVEICTEEVARELKSALSHIKLAQTG----VH 906
            |              .|:......:.::.:|.:|:....|::...||    |....:.|    ..
  Fly   278 Y--------------ILDPIYKVFDAIMNYKKEEIGTLLEKIGVTLK----HEDKDKDGKALLKT 324

  Fly   907 VQASTLGSLEALLEFLRTSKIPYSAIRI-GPVVKRDVMKASTMLEHEAQYATILAFDVKIEREAQ 970
            |..:.|.:.||||:.:        ||.: .|||.:             :|...:.::...:.||
  Fly   325 VMRTWLPAGEALLQMI--------AIHLPSPVVAQ-------------KYRMEMLYEGPHDDEA- 367

  Fly   971 EMADSLGVKIFQAD---IIY-------------HLFDKFTAYREELKQK-----------KREEF 1008
                ::.||....|   ::|             :.|.:..|.:....||           |:|:.
  Fly   368 ----AIAVKSCDPDGPLMMYISKMVPTSDKGRFYAFGRVFAGKVATGQKCRIMGPNYTPGKKEDL 428

  Fly  1009 RSVAVFPCKLRILPQFVFNSRDPIVMGVMVEN----------GIVKVGTPICVPSKEFVDIGIVT 1063
            ...|:              .|..::||..||.          |:|.|       .:..|..|.:|
  Fly   429 YEKAI--------------QRTILMMGRYVEAIEDVPSGNICGLVGV-------DQFLVKTGTIT 472

  Fly  1064 SIESNH--KQIEFARKGQEICVKIDP-IPGESPKMFG--RHFEADDMLISKISRQS 1114
            :.:..|  |.::|: ....:.|.::| .|.:.||:..  :.....|.::..|..:|
  Fly   473 TFKDAHNMKVMKFS-VSPVVRVAVEPKNPADLPKLVEGLKRLAKSDPMVQCIIEES 527

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eIF5B	NP_651974.1	PRK04004	553..1129	CDD:457675	127/633 (20%)
eEF2	NP_525105.2	PTZ00416	1..844	CDD:240409	130/641 (20%)