Protein Alignment eIF5B and Eif5b

DIOPT Version :10

• Sequence 1: NP_651974.1
• Gene: eIF5B / 44261
• FlyBaseID: FBgn0026259
• Length: 1144
• Species: Drosophila melanogaster
• Sequence 2: NP_001103611.1
• Gene: Eif5b / 308306
• RGDID: 735017
• Length: 1216
• Species: Rattus norvegicus
• Alignment Length: 1255
• Identity: 630/1255 - (50%)
• Similarity: 823/1255 - (65%)
• Gaps: 150/1255 - (11%)

  Fly     1 MVKAKKGKKEILTK-----------VEGGSSVDEISDVDSDQLSLNNKQNHALKGNQAGDDDVKA 54
            |.|.:|.|.|..||           :||..:..|    ...|.....|:    |..:..|.|...
  Rat     1 MGKKQKNKSEDSTKDDTDLGALAAEIEGAGAAKE----QEPQKGKGKKK----KEKKKQDFDEND 57

  Fly    55 VTKGVKKLNVKGKGKAGKND-------DSDEEEVV-----PAKGKASKKSAFELLMDDDEQDEPA 107
            :.:.:::|:::.:|.....|       :::|||..     ..||:..||::|    |:::.:|..
  Rat    58 ILRELEELSLEAQGIGADRDAATVKPTENNEEESASKQDKKKKGQKGKKTSF----DENDSEELE 118

  Fly   108 AQESQSEK----EEKVVVS------KPQKNEKKGKKA-----KRKGKDDDDEDLDKVLAELQAEY 157
            .::|:|:|    ..:|::|      .|.|..||||||     ||.|.::|:::..:.....:...
  Rat   119 DKDSKSKKPARPNSEVLLSGSEDADDPNKLSKKGKKAQKSTKKRDGSEEDEDNSKRSKERSRVNS 183

  Fly   158 AGEAAPAATTVVSPEELADEF--SKK--KKNKKQAKQAAVAENAGEDEASDDEEGGSTVKSAAQK 218
            :||:...          :|||  |:|  |||:|......:      |..::|::....:|:.|||
  Rat   184 SGESGGE----------SDEFLQSRKGQKKNQKNKSVPTI------DSGNEDDDSSFKIKTVAQK 232

  Fly   219 KKEKKERQ--KREAALAK----------------QKAATEPKPKPVE-----KPAPEPEPVATEE 260
            |.|||||:  |||...||                |....||:.:|.|     :..|:....:.|:
  Rat   233 KAEKKERERKKREEEKAKLRKVKEKEELEKGRKEQSKQREPQKRPDEEVLVLRGTPDAGAASEEK 297

  Fly   261 VQPAAEEEEEKSSKNKKKGKKDKKAEPEEEKKDAKKKGMSASMVAAMQEQLRKRKEEEERLEREE 325
            ...||..|::.....|||.||.||.|.::::|: ||||.|.|.|.|:||.|.|.:|||||.:|||
  Rat   298 GDIAATLEDDNEGDKKKKDKKKKKTEKDDKEKE-KKKGPSKSTVKAIQEALAKLREEEERQKREE 361

  Fly   326 AERIRLEDEREEARLEAVRLEAERKEKKKQREAERKARLKAEGKLLTKKQKEDRARAQALLESLK 390
            .|||:..:|.|..|.|..|||.|::|:|||:|.|||.|||.|||||||.|:|.||||:..|..|:
  Rat   362 EERIKRLEELEAKRKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEVTLRHLQ 426

  Fly   391 AQGLEIPDPND---KRPTRPGTRIRPNKKKGPKEEAAEEEAKAAEAEA------QSAAAAAAAAA 446
            |||:|:|..:.   |||.....:    |||.|::..::|..:..|..|      |..........
  Rat   427 AQGVEVPSKDSLPKKRPVYEDKK----KKKTPQQLESKEALETVEVSAPVEVVDQGVPEKEETPP 487

  Fly   447 AEKAEEERVKE-----SWD--ATDSEAEPEPEEETSQATNNGKTEAAEEENEDTDDDEDDDD--- 501
            :..|||:...|     .|:  |:|.|.|.|......:...|.:.|..|||:||.:|.||::|
  Rat   488 SVDAEEDEETEDAGLDDWEAMASDEEREKEGNMIHIEVEENPEEEEEEEEDEDEEDSEDEEDEGD 552

  Fly   502 ------DEDD---------------------SDDSDGDSDDSREVSVLANDPESRRLRAEARILK 539
                  ||:|                     |.||:.||||.|.....|.|      :|:.||.|
  Rat   553 SEGSDGDEEDYKLSDEKDLGKAGDTKPNKDASSDSEYDSDDDRTKEERAYD------KAKRRIEK 611

  Fly   540 RQAEAEKKRSTDELRAGVVCVLGHVDTGKTKILDKLRRTHVQDSEAGGITQQIGATNVPIEAIKE 604
            |:.|..|..:|::|||.::||||||||||||||||||.|||||.|||||||||||||||:|||.|
  Rat   612 RRLEHGKNVNTEKLRAPIICVLGHVDTGKTKILDKLRHTHVQDGEAGGITQQIGATNVPLEAINE 676

  Fly   605 QTKYVKAAAGFEHRLPGLLIIDTPGHESFSNLRNRGSSLCDIAILVVDIMHGLEPQTIESIQLLK 669
            |||.:|.......|:||:|||||||||||||||||||||||||||||||||||||||||||.:||
  Rat   677 QTKMIKNFDRENVRIPGMLIIDTPGHESFSNLRNRGSSLCDIAILVVDIMHGLEPQTIESINILK 741

  Fly   670 KKKCPFIVALNKIDRLYDWKQLARRDVRDVLKEQQSNTQLEFQQRTKDVILQFAEQGLNAALFYE 734
            .|||||||||||||||||||:....||...||:|:.||:.||::|.|.:|::||:||||||||||
  Rat   742 SKKCPFIVALNKIDRLYDWKKSPDSDVAVTLKKQKKNTKDEFEERAKAIIVEFAQQGLNAALFYE 806

  Fly   735 NTDPKTYISLVPTSAISGEGMGNLLFMIADFCQNMLAKRLMYSEELQATVLEVKALPGLGTTIDA 799
            |.||:|::|||||||.:|:|||:|::::.:..|.||:|||.:.|||:|.|:|||||||:|||||.
  Rat   807 NKDPRTFVSLVPTSAHTGDGMGSLIYLLVELTQTMLSKRLAHCEELRAQVMEVKALPGMGTTIDV 871

  Fly   800 ILINGKLREGQTMVVAGTDGPIVTQIRSLLMPQPMKELRVKNAYVEYKEVKAAQGVKIAAKDLEK 864
            |||||:|:||.|::|.|.:||||||||.||:|.|||||||||.|.::|||:|||||||..|||||
  Rat   872 ILINGRLKEGDTIIVPGVEGPIVTQIRGLLLPPPMKELRVKNQYEKHKEVEAAQGVKILGKDLEK 936

  Fly   865 AIAGINLLIAHKPDEVEICTEEVARELKSALSHIKLAQTGVHVQASTLGSLEALLEFLRTSKIPY 929
            .:||:.||:|:|.||:.:..:|:..|||..|:.|||.:.||:||||||||||||||||:||::||
  Rat   937 TLAGLPLLVAYKDDEIPVLKDELIHELKQTLNAIKLEEKGVYVQASTLGSLEALLEFLKTSEVPY 1001

  Fly   930 SAIRIGPVVKRDVMKASTMLEHEAQYATILAFDVKIEREAQEMADSLGVKIFQADIIYHLFDKFT 994
            :.|.||||.|:||||||.||||:.|||.||||||:|||:||||||||||:||.|:|||||||.||
  Rat  1002 AGINIGPVHKKDVMKASVMLEHDPQYAVILAFDVRIERDAQEMADSLGVRIFSAEIIYHLFDAFT 1066

  Fly   995 AYREELKQKKREEFRSVAVFPCKLRILPQFVFNSRDPIVMGVMVENGIVKVGTPICVPSKEFVDI 1059
            .||::.|::|:|||:.:||||||::||||::||||||||:||.||.|.||.|||:|||||.||||
  Rat  1067 KYRQDYKKQKQEEFKHIAVFPCKMKILPQYIFNSRDPIVIGVTVEAGQVKQGTPMCVPSKNFVDI 1131

  Fly  1060 GIVTSIESNHKQIEFARKGQEICVKIDPIPGESPKMFGRHFEADDMLISKISRQSIDACKDYFRD 1124
            |||||||.||||::.|:||||:||||:||||||||||||||||.|:|:||||||||||.||:|||
  Rat  1132 GIVTSIEINHKQVDVAKKGQEVCVKIEPIPGESPKMFGRHFEATDILVSKISRQSIDALKDWFRD 1196

  Fly  1125 DLIKADWALMVELKKLFEIL 1144
            ::.|:||.|:|||||:|||:
  Rat  1197 EMQKSDWQLIVELKKVFEII 1216

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eIF5B	NP_651974.1	PRK04004	553..1129	CDD:457675	411/575 (71%)
Eif5b	NP_001103611.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..604		199/641 (31%)
		PRK04004	623..1198	CDD:457675	411/574 (72%)
		G1. /evidence=ECO:0000255|PROSITE-ProRule:PRU01059	634..641		6/6 (100%)
		G2. /evidence=ECO:0000255|PROSITE-ProRule:PRU01059	659..663		3/3 (100%)
		G3. /evidence=ECO:0000255|PROSITE-ProRule:PRU01059	698..701		2/2 (100%)
		G4. /evidence=ECO:0000255|PROSITE-ProRule:PRU01059	752..755		2/2 (100%)
		G5. /evidence=ECO:0000255|PROSITE-ProRule:PRU01059	820..822		1/1 (100%)