DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment eIF5B and HBS1

DIOPT Version :9

Sequence 1:	NP_001246599.1	Gene:	eIF5B / 44261	FlyBaseID:	FBgn0026259	Length:	1144	Species:	Drosophila melanogaster
Sequence 2:	NP_001286906.1	Gene:	HBS1 / 117365	FlyBaseID:	FBgn0042712	Length:	670	Species:	Drosophila melanogaster

Alignment Length:	708	Identity:	140/708 - (19%)
Similarity:	243/708 - (34%)	Gaps:	224/708 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   311 LRKRKEEEERLEREEAERIRLEDEREEARLEAVRLEAERKEKKKQREAERKARLK---------- 365
            :.|.|:    ::.|||:    |||.|:|.....|.::|..:..:..|.| :|:|.
  Fly    56 ISKNKD----IQEEEAD----EDEDEDAAFAKARRDSESFQMPQLDEIE-QAKLSSCVDEVRSVV 111

  Fly   366 ----AEGKLLTKKQKEDRARAQALLESLKAQGLEIPDPNDKRPTRPGTRIRPNKKKGPKEEAAEE 426
                :|.:::....|.| ...|.:|:       ||.:....:..:|..    ||.|.|
  Fly   112 GDAVSERRIVETSMKFD-YDMQKILD-------EILNEETNKSAKPAV----NKMKAP------- 157

  Fly   427 EAKAAEAEAQSAAAAAAAAAAEKAEEERVKESWDATDSEAEPEPEEETSQATNNGKTEAAEEENE 491
                |........:........|...:..:..::.      |.|:..:|...:...|..
  Fly   158 ----AAPVLPKTVSKTVPTPPPKISLKEPRRGFEI------PSPKVPSSPVVSGRNTPV------ 206

  Fly   492 DTDDDEDDDDDEDDSDDSDGDSDDSREVSVLANDPESRRLRAEARILKRQAEAEKKRSTDELRAG 556
                           |.|.|| |.||..:.:....:.:.:| .||.|..:..|::|....
  Fly   207 ---------------DISAGD-DISRSSATVFKVSKEQAVR-NARQLYEKERADQKSHIH----- 249

  Fly   557 VVCVLGHVDTGKTKIL-----------DKLRRTHVQDSE--------------------AGGITQ 590
             :.|:||||.||:.::           .::...|.|:|:                    |.|||.
  Fly   250 -MIVIGHVDAGKSTLMGHLLYDTGNVSQRVMHKHEQESKKLGKQSFMYAWVLDETGEERARGITM 313

  Fly   591 QIGATNVPIEAIKEQTKYVKAAAGFEHRLPGLLIIDTPGHESFSNLRNRGSSLCDIAILVVDIMH 655
            .:|.:.     |:.:||.|             .::|.|||:.|......|::..|:|:||||...
  Fly   314 DVGQSR-----IETKTKIV-------------TLLDAPGHKDFIPNMISGATQADVALLVVDATR 360

  Fly   656 G-------LEPQTIESIQLLKKKKCPFI-VALNKIDRLYDWKQLARRDVRDVLKEQQSNTQLEFQ 712
            |       |..||.|...|::......: |.:||:|.: .|.|....::...||.
  Fly   361 GEFESGFELGGQTREHAILVRSLGVNQLGVVINKLDTV-GWSQDRFTEIVTKLKS---------- 414

  Fly   713 QRTKDVILQFAEQGLNAALFYENTDPKTYISLVPTSAISGEGM--------------GNLLFMIA 763
                  .|:.|.        ::::|    :|..|.|.::||.:              |..|.
  Fly   415 ------FLKLAG--------FKDSD----VSFTPCSGLTGENLTKKAQEPALTNWYSGRHLL--- 458

  Fly   764 DFCQNMLAKRLMYSEELQATVLEVKALPGLGTTIDAILINGKLREGQTMVVAGTDGPIV------ 822
            |..:|...........|:.:|.::....|.|     ..|:|::..|   |:...|..:|
  Fly   459 DVIENFKIPERAIDRPLRMSVSDIYKGTGSG-----FCISGRVETG---VLCLNDKVLVGASREQ 515

  Fly   823 TQIRSLLMPQPMKELRVKNAYVEYKEVKAAQG----VKIAAKDLEKAIAGINLLIAHKPDEVEIC 883
            .|::||.|.             |:.:.....|    |.:.|.|:.....|  .:|:.....:.:.
  Fly   516 AQVKSLTMN-------------EFPQTCVFAGDQVSVTLPALDINNVTVG--CIISDPQTPIPVT 565

  Fly   884 TEEVARELKSALSHIKLAQT-GVHVQASTLGSLEALLEFLRTSKIPYSAIRIGPVVKR 940
            |...||.:   :.::|:..| |..|.......:|..:....|:.|..|.   |.|||:
  Fly   566 TRFQARII---VFNVKVPITMGFPVLLHHQSLIEPAVVCKLTASIHKST---GEVVKK 617

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF5B	NP_001246599.1	PRK04004	553..1129	CDD:235195	93/452 (21%)
		IF2_eIF5B	557..769	CDD:206674	56/264 (21%)
		aeIF5B_II	779..889	CDD:293904	22/119 (18%)
		IF-2	890..993	CDD:288813	12/52 (23%)
		IF2_aeIF5B_IV	1016..1110	CDD:293911
HBS1	NP_001286906.1	HBS1_N	83..145	CDD:286079	12/70 (17%)
		TEF1	241..669	CDD:227581	95/462 (21%)
		EF1_alpha	249..468	CDD:206670	57/274 (21%)
		HBS1-like_II	474..557	CDD:293912	21/105 (20%)
		HBS1_C_III	561..669	CDD:294008	15/63 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45464664
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930