DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eIF1A and EIF1AY

DIOPT Version :9

Sequence 1:	NP_001287386.1	Gene:	eIF1A / 44260	FlyBaseID:	FBgn0026250	Length:	148	Species:	Drosophila melanogaster
Sequence 2:	NP_004672.2	Gene:	EIF1AY / 9086	HGNCID:	3252	Length:	144	Species:	Homo sapiens

Alignment Length:	148	Identity:	114/148 - (77%)
Similarity:	126/148 - (85%)	Gaps:	4/148 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPKNKGKGGKNRRRGKNENEFEKRELIFKEDQQEYAQVTKMLGNGRLEAMCFDGVKRLCHIRGKL 65
            ||||||||||||||||||||.|||||:||||.||||||.||||||||||:|||||||||||||||
Human     1 MPKNKGKGGKNRRRGKNENESEKRELVFKEDGQEYAQVIKMLGNGRLEALCFDGVKRLCHIRGKL 65

  Fly    66 RKKVWINQGDIILVGLRDYQDSKADVILKYTPDEARNLKTYGEFPESVRINETVTFVEDGFDEDI 130
            |||||||..||||||||||||:||||||||..||||:||.|||.||..:||||.|| ..|.|::|
Human    66 RKKVWINTSDIILVGLRDYQDNKADVILKYNADEARSLKAYGELPEHAKINETDTF-GPGDDDEI 129

  Fly   131 EFGDEISSEDDADSVDNI 148
            :| |:|.  ||.:.:|:|
Human   130 QF-DDIG--DDDEDIDDI 144

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF1A	NP_001287386.1	PTZ00329	1..147	CDD:185558	112/145 (77%)
EIF1AY	NP_004672.2	PTZ00329	1..131	CDD:185558	107/130 (82%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26		23/24 (96%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	114..144		15/33 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155204
Domainoid	1	1.000	119	1.000	Domainoid score	I5810
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H100715
Inparanoid	1	1.050	228	1.000	Inparanoid score	I3470
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54096
OrthoDB	1	1.010	-	-		D1426335at2759
OrthoFinder	1	1.000	-	-		FOG0000631
OrthoInspector	1	1.000	-	-		otm41457
orthoMCL	1	0.900	-	-		OOG6_100738
Panther	1	1.100	-	-	O	PTHR21668
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R590
SonicParanoid	1	1.000	-	-		X376
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.900