DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nbs and Nbn

DIOPT Version :9

Sequence 1:	NP_651973.4	Gene:	nbs / 44259	FlyBaseID:	FBgn0261530	Length:	818	Species:	Drosophila melanogaster
Sequence 2:	XP_006237978.3	Gene:	Nbn / 85482	RGDID:	621420	Length:	776	Species:	Rattus norvegicus

Alignment Length:	780	Identity:	192/780 - (24%)
Similarity:	303/780 - (38%)	Gaps:	194/780 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 YTIGRLATDLIVAQDLSISRNHAQLLIQ------TEADGDDTLHIEDLGSRYGTFIFPKNSQKPR 78
            |.:||....:::..|.|||||||.|.:.      ::.|...||.|:| .|:|||||      ...
  Rat    50 YIVGRKNCAILIENDQSISRNHAVLRVNFPVTSLSQTDEIPTLTIKD-NSKYGTFI------NEE 107

  Fly    79 KVPAKTSTPLPVGTRLRFGANMSIWQVTQLKLVTTVSALTRSEVQELTKMLEPMGGTVTSNWTEE 143
            |:....|:.|..|.|:.||...|.::|....||...|.|..|....|.:.:..:||...::||||
  Rat   108 KMLNGLSSTLKTGDRVTFGVFESKFRVEYEPLVVCSSCLDVSGKTVLNQAILQLGGLTANSWTEE 172

  Fly   144 CSHLTMNEVSVTVKLLHAMLENKPIVTFPYWRKMLQAAQSIHVKEGWPQPEDYQP---------T 199
            |:||.|:.|.||:|.:.|::..:|||...|:.:.|:|.:|   |...|:.|.:.|         .
  Rat   173 CTHLAMSSVKVTIKTICALICGRPIVKPEYFSEFLKAVES---KTQPPEIESFYPPIDEPAIGNK 234

  Fly   200 NIDVTWRPERTRLFAGKTFVFMNRKHFDMYGSVVQKAGATCKDINSG--VRKTFLTKSDVIVIQY 262
            ::|::.|.||.::|.||||||:|.|.....||.|...|...:.:..|  ..::|.:.....|:..
  Rat   235 SVDLSGRRERKQIFKGKTFVFLNAKQHKKLGSAVVFGGGEARLMAEGGEEEQSFFSAPGTCVVDV 299

  Fly   263 -VPSSQSQATES----INSIQDRYILEQNGRRIIQEYEIGMALIHCSITEFCNPTHK-------- 314
             :.::|...|:|    |:.|.|  ||:::|.|.|.|.|||:|:|..:...:|||..:
  Rat   300 GITNTQLIITDSQRKWIHLIMD--ILQRHGLRPIPEAEIGLAVIFMTTESYCNPQGQPCTEVKTT 362

  Fly   315 ----FISDSLPTTESVTSSMAFNSSIIVPNTERHSAQSNATPISELVVPESIECEMEQDASKPHS 375
                .:|..|.....|..|...|.:..|.:||...|.: ...:||.  ||.:         |...
  Rat   363 TPGPSLSQGLSANGKVIPSAPMNMTTYVADTESEPADT-CMSLSER--PEEV---------KIFG 415

  Fly   376 EDQASLRKRSHASTVDSSDEEKKSTLSKRAKSDIATKLTMKSKNAILLDSSLEEDVTPAPAPAPV 440
            .||.|  ::....|.:..:...:|:.|..|.|           |.::...:....::|...||..
  Rat   416 LDQNS--RKLLQGTCNIKETSNQSSNSNNAAS-----------NTLVRGKAPNYQLSPMKCPAAS 467

  Fly   441 QRVTRQS-KAIAEEKSVHPPVPAASKHITRKTKQVFCVDSSDEENENARKPK-----------ET 493
            :.....| :.:...|:...|       .:||.::       ||||......|           |.
  Rat   468 KNKDWSSQQQLNSIKNYFQP-------CSRKRER-------DEENPEQSSCKSSRVELSCSLLEQ 518

  Fly   494 PAPTIPSMAKKK------------TEAPVATRISPRLNG-----KSLATN------------ITN 529
            ..|..||:.|.|            :.|.....|..:.||     ||.:|.            .|.
  Rat   519 TQPAGPSLWKSKDHESQSETLDRASNASSVGGIDIKPNGKSPDSKSFSTEDLRARKRKEVDLSTE 583

  Fly   530 QPADKHAVPAKRPVLSVASSDEEDEGDLFQFRKSPQKPAE--------------TVVQPRIAGKG 580
            :...:..:.:.:|.|:|....|:.|.|: ..||.|:..||              :.:|....||.
  Rat   584 EEVLEELLRSTKPELAVQVKVEKQEADV-SIRKKPRMDAERNQHLNGGPVPESNSALQEDETGKK 647

  Fly   581 NAPARISVVDFLEKSQAQEPAPVPPQLESQSQTQPRKRLRLE-----LLNESDSDDC-----DNL 635
            :   .:.:..:..|.:......:|    ..|:..|||.|..|     :.|.|..:.|     ..|
  Rat   648 D---ELQIEAWSTKREVSNTDELP----DSSEELPRKLLLTEFRSLVVHNNSSRNLCVLNGRGEL 705

  Fly   636 FNFADSKK-----------------------------------KRKTQEAQRNDDS-TDGLFNFN 664
            .||...||                                   :.:.|:.|..:|| .|.||.:|
  Rat   706 KNFKKFKKATCPGAGKLPHIIGGSDLIGHHARKNTELEEWLKHEMEVQKQQAKEDSLADDLFRYN 770

Fly 665 664
Rat 771 770

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nbs	NP_651973.4	FHA	3..98	CDD:238017	29/83 (35%)
		FHA	<8..99	CDD:224630	30/84 (36%)
		BRCT	115..171	CDD:237994	22/55 (40%)
		NIBRIN_BRCT_II	207..311	CDD:293117	36/110 (33%)
Nbn	XP_006237978.3	FHA	37..135	CDD:238017	31/91 (34%)
		BRCT_nibrin	137..210	CDD:349372	26/72 (36%)
		NIBRIN_BRCT_II	243..351	CDD:406819	36/109 (33%)
		Nbs1_C	706..767	CDD:400771	9/60 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166339855
Domainoid	1	1.000	54	1.000	Domainoid score	I11025
eggNOG	1	0.900	-	-		E1_2CMFP
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	144	1.000	Inparanoid score	I4364
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006929
OrthoInspector	1	1.000	-	-		oto96637
orthoMCL	1	0.900	-	-		OOG6_106244
Panther	1	1.100	-	-	LDO	PTHR12162
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X6655
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.750