Protein Alignment nbs and NBS1

DIOPT Version :9

• Sequence 1: NP_651973.4
• Gene: nbs / 44259
• FlyBaseID: FBgn0261530
• Length: 818
• Species: Drosophila melanogaster
• Sequence 2: NP_186917.2
• Gene: NBS1 / 821254
• AraportID: AT3G02680
• Length: 542
• Species: Arabidopsis thaliana
• Alignment Length: 684
• Identity: 149/684 - (21%)
• Similarity: 254/684 - (37%)
• Gaps: 215/684 - (31%)

  Fly     8 DEKFVLFPGKKVYTIGRLATDLIVAQDLSISRNHAQLLI--------QTEADGDDT----LHIED 60
            ::|:.:| .|.:|.:||...|:|:.:|..:||.||:|..        :......||    :.::|
plant    14 EDKYYIF-SKGIYKVGRKGCDIIINKDKGVSRIHAELTFDATTVSTSRRNKSSSDTSSFVIRVKD 77

  Fly    61 LGSRYGTFIFPK--NSQKPRKVPAKTSTPLPVGTRLRFGANMSIWQVTQLKLVTTV--SALTRSE 121
            . |:||||:...  ...|..::..|... |..|..:.||...:|::::.:.||..:  |:.|...
plant    78 C-SKYGTFVKTDLGTKDKVHELSNKEKI-LQDGDVIAFGTGSAIYRLSLIPLVFYLCPSSETFKV 140

  Fly   122 VQELTKMLEPMGGTVTSNWTEECSHLTMN-EVSVTVKLLHAMLENKPIVTFPYWRKMLQAAQSIH 185
            .|.:...:..:|..::...:|||:|:.:. .:.|...|::|:|..|.|: ...| .||.|.:||.
plant   141 DQPVQDAVSSIGARISPTLSEECTHVLLEPRMQVNEALINAILAKKTII-LTNW-VMLLAEKSIC 203

  Fly   186 VK-EGWPQPEDYQPT------NIDVTWRPERTRLFAGKTFVFMNRKHFDMY------GSVVQKAG 237
            .: .|:.|   |:|:      .:||.....|.:...|.|||.   :..|.|      .|:::..|
plant   204 SEIPGYSQ---YRPSVMVEEALVDVLELNVREKCLEGFTFVL---EPTDTYRFGCSFPSLLEVCG 262

  Fly   238 A---TCKDINSGVRKTFLTKSDVIVIQYVPSSQSQATESINSIQDRYILEQNGRRIIQEYEIGMA 299
            |   |.:||:|..:.:...:.:.::. .:|.|   |.:.....:...:|.:     :.|    |.
plant   263 AETVTIEDISSMSQDSQFGEINRMIC-VIPKS---AGDKFGRFKHLSLLSR-----VNE----MD 314

  Fly   300 LIHCSITEFCNPTHKFISDSLPTTESVTSSMAFNSSIIVPNTERHSAQSNATPISELVVPESIEC 364
            |: |::          .|.:||:|..:..|:..:||.   :|:            |.||.:| |.
plant   315 LV-CAV----------FSGNLPSTSLIPPSVVISSSC---STD------------ETVVADS-EA 352

  Fly   365 EMEQDASKPHSEDQASLRKRSHASTVDSSDEEKKSTLSKRAKSDIATKLTMKSKNAILLDSSLEE 429
            |.|:..|..|..|..                ||..|..|.|              ||:::.|
plant   353 EEEETTSSVHMIDAT----------------EKAETPEKPA--------------AIVIEDS--- 384

  Fly   430 DVTPAPAPAPVQRVTRQSKAIAEEKSVHPPVPAASK-HITRKTKQVFCVDSSDEENENARKPKET 493
                     || .:..::..:.|.|||:......|: |:..|       :|||  :...|:.:..
plant   385 ---------PV-TILEETSNLNEFKSVNLLADTESRGHMDEK-------NSSD--SVTIRRDRND 430

  Fly   494 PAPTIPSMAKKKTEAPVATRISPRLNGKSLATNITNQPADKHAVPAKRPVLSVASSDEEDEGDLF 558
            .|.|                      |||                      .:..:.:....||.
plant   431 EAET----------------------GKS----------------------EIIYTQDLIVRDLR 451

  Fly   559 QFRKSPQKPAETVVQPRIAGKGNAP---ARISVVDFLEKSQAQEPAPVPPQLESQSQTQPRKRLR 620
            ..||......|.||..:...|||..   :..|::.|     |::|
plant   452 STRKVQSTGGEGVVDFKRFRKGNVTCGNSFSSLIPF-----AKDP-------------------- 491

  Fly   621 LELLNESDSDDCDNLFNFADSKKKRKTQEAQRND 654
               ..|.||.|   :.:|...:||||..||...|
plant   492 ---YKEYDSWD---VTDFMKEEKKRKQMEAIAED 519

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nbs	NP_651973.4	FHA	3..98	CDD:238017	27/103 (26%)
		FHA	<8..99	CDD:224630	28/104 (27%)
		BRCT	115..171	CDD:237994	14/56 (25%)
		NIBRIN_BRCT_II	207..311	CDD:293117	22/112 (20%)
NBS1	NP_186917.2	FHA	2..124	CDD:238017	29/112 (26%)
		FHA	<24..148	CDD:224630	31/125 (25%)
		Nbs1_C	467..522	CDD:285765	19/84 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_2CMFP
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006929
OrthoInspector	1	1.000	-	-		oto3237
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR12162
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.910