DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nbs and nbn

DIOPT Version :9

Sequence 1:	NP_651973.4	Gene:	nbs / 44259	FlyBaseID:	FBgn0261530	Length:	818	Species:	Drosophila melanogaster
Sequence 2:	XP_004915210.2	Gene:	nbn / 733826	XenbaseID:	XB-GENE-943036	Length:	773	Species:	Xenopus tropicalis

Alignment Length:	886	Identity:	185/886 - (20%)
Similarity:	330/886 - (37%)	Gaps:	243/886 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 FVLTKDDEKFVLFPGKKVYTIGRLATDLIVAQDLSISRNHAQLLIQ------TEADGDDTLHIED 60
            ::||..|           |.:||....:::..|.||||.||.|.:.      ::.:....|.|:|
Frog    15 YILTGTD-----------YVVGRKNCAILIPDDQSISRCHATLSVSYPSASLSQTNAVSVLTIKD 68

  Fly    61 LGSRYGTFIFPKNSQK--PRKVPAKTSTPLPVGTRLRFGANMSIWQVTQLKLVTTVSALTRSEVQ 123
             .|:|||.:..:..|.  ||.        |.....:.||...|.::|....||...|.|..:|..
Frog    69 -SSKYGTTVSGERMQPAVPRS--------LKPSDEVIFGCFHSKYRVEYEPLVVCSSCLDNTEKN 124

  Fly   124 ELTKMLEPMGGTVTSNWTEECSHLTMNEVSVTVKLLHAMLENKPIVTFPYWRKMLQAAQSIHVKE 188
            .|.:.|..:||.:.:||||:|:||.|..:.||:|.:.|::..|||:...|:|:::.|     :::
Frog   125 SLKQNLIHLGGHMLNNWTEKCTHLVMTSIKVTIKTICALICCKPIIKPDYFRELINA-----IQQ 184

  Fly   189 GWPQPE-----------DYQPTNIDVTWRPERTRLFAGKTFVFMNRKHFDMYGSVVQKAGATCKD 242
            ..|.||           ...|.::|::...:|..:|..|.|:|:|.|.:......|...|.....
Frog   185 KRPLPEYRSFIPPIDEPSLNPESLDLSENVKRKSIFKDKVFLFLNTKQYMKLSPAVLLGGGKAHL 249

  Fly   243 INSGVRKTFLTKSDVIVIQYVPS----SQSQATES-INSIQDRYILEQNGRRIIQEYEIGMALIH 302
            :.|....:.|..|...||....:    |::|:|:. |:...|  :|...|.|.|.|.|||:|:|:
Frog   250 LESLTDTSVLENSTTCVIDVAMTETQLSETQSTQPWISCTLD--LLHSKGLRAIPEAEIGLAVIN 312

  Fly   303 CSITEFCNPTHKFISDSLPTTESVTSSMAFNSSIIVPNTER----HSAQSNATPISELVVPESIE 363
            .|...:|||.....|.:    |:..:..:|..:.:...::|    .|..|....:.|.|:| :..
Frog   313 VSTEIYCNPRRLAASGN----EAGNNDFSFPKATVKETSKRTQVLSSTLSQGMTVDETVLP-APA 372

  Fly   364 CEMEQDASKPHSEDQ-------ASLRKRSHASTVDSSDEEKKSTLSKRAKSDIATKLTMKSKNAI 421
            ..|....:....:||       :.:|:........||....:|.:.|..||..:..|.
Frog   373 LNMTAYVADTEPQDQTDTGMNISGVREVKETPGSSSSHSRSRSCIEKEPKSGSSNDLR------- 430

  Fly   422 LLDSSLEEDVTPAPAPAPVQRVTRQSKAIAEEKSVHP--PVPAASKHITRKTKQVFCVDSSDEEN 484
                               |.:.:..|.....|:.||  |:..:::.:.:.::::
Frog   431 -------------------QALFQGDKTETRNKNNHPLLPIKPSARDVGKTSQKL---------- 466

  Fly   485 ENARKPKETPAPTIPSMAKKKTEAPVATRISPRLNGKSLATNITNQPADKHAVPAKRPVLSVASS 549
                :|.:.......|:|||:                      .....:|....||...:...||
Frog   467 ----QPTKKIDSYFQSLAKKR----------------------DRDEDEKEVSSAKLARVEPVSS 505

  Fly   550 DEEDEGDLFQFRKSPQKPAETVVQPRIAGKGNAPARISVVDFLEKSQAQEPAPVPPQLESQSQTQ 614
            ...:|    |||                                        |:...|:.:...
Frog   506 QNTEE----QFR----------------------------------------PITEALDKEEDN- 525

  Fly   615 PRKRLRLELLNESDSD-----DCDNLFNFAD-------SKKKRKTQE---AQRND-DSTDGLFNF 663
                      .:||.|     .||.:...::       :.||||..:   .:.:| ||.:|: :.
Frog   526 ----------FDSDLDMELAMSCDQILMGSNKVIPEDPTMKKRKVPDDHVVEESDIDSDEGI-SA 579

  Fly   664 NSERPSDHDDEDSRLTEPFVPETESKKQSKYIVAPRRDRPKKVDISGWLSCS--RLNDNIKSEID 726
            |:|:    :|.:|.|.:....:.:||.:.   |.....:|.::........:  .:..::|.||:
Frog   580 NAEQ----NDTESNLNKTKKRKLDSKIEG---VKELTIKPHEIGTKAQAKTNTPEMEPSVKKEIE 637

  Fly   727 ADSVKMETSIKADPDEEQW-------LAAMKDSIEVRMCNL---NIVIRSQEEVDASLEDSVNKH 781
               ||.|..:|.:|:..|.       ||...|::..|:...   ::|:......:.:..:|.|::
Frog   638 ---VKTEFEVKKEPESPQKETKCVPDLAGESDALPSRLLLTEFKSLVVTRPVRNNNTTSNSSNEN 699

  Fly   782 GGRKNFKKFVKTKNP----------------HPQKRIVALK 806
              .:|||||.|...|                |.:||...|:
Frog   700 --CQNFKKFKKVAYPGAGSFPHIIGGSDLIAHDRKRNAELE 738

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nbs	NP_651973.4	FHA	3..98	CDD:238017	26/102 (25%)
		FHA	<8..99	CDD:224630	25/98 (26%)
		BRCT	115..171	CDD:237994	22/55 (40%)
		NIBRIN_BRCT_II	207..311	CDD:293117	31/108 (29%)
nbn	XP_004915210.2	FHA	1..107	CDD:238017	28/111 (25%)
		BRCT_nibrin	109..182	CDD:349372	27/77 (35%)
		NIBRIN_BRCT_II	215..321	CDD:406819	31/107 (29%)
		Nbs1_C	701..762	CDD:400771	11/38 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	49	1.000	Domainoid score	I11690
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006929
OrthoInspector	1	1.000	-	-		oto103338
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5636
SonicParanoid	1	1.000	-	-		X6655
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.030