DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nbs and nbn

DIOPT Version :9

Sequence 1:	NP_651973.4	Gene:	nbs / 44259	FlyBaseID:	FBgn0261530	Length:	818	Species:	Drosophila melanogaster
Sequence 2:	NP_001014819.1	Gene:	nbn / 544655	ZFINID:	ZDB-GENE-041008-35	Length:	818	Species:	Danio rerio

Alignment Length:	838	Identity:	192/838 - (22%)
Similarity:	343/838 - (40%)	Gaps:	141/838 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 EKFVLFPGKKVYTIGRLATDLIVAQDLSISRNHAQLLIQTEADGDDTLHIEDLGSRYGTFIFPKN 73
            |..:|..|:: |.:||...::::..|.||||.||.|.:..:|     :.::| .|:||||:   |
Zfish    12 ESVILLAGQE-YVVGRKNCEILLTNDQSISRVHAVLTVTEQA-----VTLKD-SSKYGTFV---N 66

  Fly    74 SQKPRKVPAKTSTPLPVGTRLRFGANMSIWQVTQLKLVTTVSALTRSEVQELTKMLEPMGGTVTS 138
            .:|......||   |..|.::.||...|.:.:.:..:|...|.:.......|::.:..:||.:.|
Zfish    67 GEKLESGSTKT---LQTGYKITFGVFQSKFSLEKECIVVCSSCVDNEGKVTLSQDIRSVGGRLVS 128

  Fly   139 NWTEECSHLTMNEVSVTVKLLHAMLENKPIVTFPYWRKMLQAAQSIHVKEGWPQPEDYQP----- 198
            :||.:|:||.|..|.||:|.:.|:|..:|||...::....:|.|.   |...|:.|.::|
Zfish   129 SWTSDCTHLVMPTVKVTIKTICALLCCRPIVKPAFFSAFSKAVQQ---KLPLPKAERFRPQIDEP 190

  Fly   199 ----TNIDVTWRPERTRLFAGKTFVFMNRKHFDMYGSVVQKAGATCKDINSGVRKTFLTKSDVIV 259
                ..:|:..||||..||.||||:|::.|........|...|...:.::.|.....|.:|....
Zfish   191 SLARDEVDLGARPERKSLFKGKTFLFLSSKQMKRLSVAVSCGGGVSQLLDEGALPVSLLESSSTC 255

  Fly   260 IQYVPSSQSQATES------INSIQDRYILEQNGRRIIQEYEIGMALIHCSITEFCNPTHKFISD 318
            :..:.|..||...|      ::|:..  ||.:.|.|.|.|.|:|:|.||.|...:|||.....|:
Zfish   256 VLDMISGNSQPVISPASKKWLDSVGQ--ILHRKGLRFITESEVGLAAIHVSNQTYCNPCSSLQSE 318

  Fly   319 SLPTTESVTSSMAFNSSIIVPNTERHSAQSNATPISELVVPESIECEMEQDASKPHSEDQASLRK 383
            |: .|..|.:|...:.|..|..|...:...|.|..       .:..|:.||.|:         ..
Zfish   319 SV-KTNPVFASATLSQSTAVDETALAAPSQNITAY-------VVNTEISQDQSR---------MV 366

  Fly   384 RSHASTVDSSDE-----EKKSTLSK-------RAKSDIATKLTMKSKNAILLDSSLEEDVTPAPA 436
            .|..|.|..:.|     :|.||.:|       .:.:.|..:..|.|::..:::|
Zfish   367 TSGISAVGETPEKTNPTQKASTTNKPLSLGQEPSSTRIVQETVMSSESFSVVES----------- 420

  Fly   437 PAPVQRVTRQSKAIAEEKSVHPPV----PAASKHITRKTKQVFCVDSSDEENENARKPKETPAPT 497
                ::..::...::....|..||    |::.....:.:.|.....:|..:..:.::|:|:.|.:
Zfish   421 ----EQKMKKGSVVSARGRVEGPVKQKAPSSGNTTLKHSPQKQTALTSFFQPSSKKRPRESSASS 481

  Fly   498 I---PSMAKKKTEAPVATRISPRLNGKSLATNITNQPADKHAVPAKRPVLSVASSDEEDEGDLFQ 559
            :   |...||.        |....:....::::..    .|...::...|..|....::...  :
Zfish   482 VQPEPKFFKKD--------IKDNEDDIQQSSSVNR----SHKTSSEETSLGQACGTGQNSSS--K 532

  Fly   560 FRKSPQKPAETVV---QPRIAGKGNAPARISVVDFLEKSQAQEPAPVPPQLESQSQTQPRKRLRL 621
            .||.|::  :|::   :|..|  .:....:..::||...:..||          .||...|:.||
Zfish   533 KRKEPEQ--DTLLGAEEPTAA--DDLEMSLEELEFLMSDEMDEP----------PQTAANKKQRL 583

  Fly   622 E--LLNESDSDDCDNLFNFADSKKKRKTQEAQRNDDSTDGLFNFNSERPS----DHDDEDSRLTE 680
            |  |.::.:|:...|.....:| |.||.::.|::..|.......:...|:    |...:..|...
Zfish   584 ESGLTSKINSEQLSNQQEVTES-KGRKGEKNQQSSSSNIQSMQLDRAGPAVTNQDTQTQSKRSPP 647

  Fly   681 PFVPETESKKQSKYIVAPRRDRPKKVDISGWLSCSRLNDNIKSEIDA---DSVKMETS---IKAD 739
            .....:.:.|.......|..:..||.::| ::..||..:.|....:|   ..::..||   .|.|
Zfish   648 DLEAHSSANKGPTKNKTPELEEVKKEEVS-FVVNSRPQNGISQTSEAVLKQEMRASTSNSGPKND 711

  Fly   740 PDEEQWLAAMKDSIEVRMCNLNIVIRSQEEVDASLEDSVNKHG-GRKNFKKFVKTKNP 796
            ||..:.|      ::|:..:|.:...|:     |....:..|. ..||.|:|.|...|
Zfish   712 PDLPRKL------LQVQFMSLTVNNSSR-----SRPGPLQTHNPNDKNVKRFRKKNVP 758

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nbs	NP_651973.4	FHA	3..98	CDD:238017	28/88 (32%)
		FHA	<8..99	CDD:224630	29/89 (33%)
		BRCT	115..171	CDD:237994	20/55 (36%)
		NIBRIN_BRCT_II	207..311	CDD:293117	34/109 (31%)
nbn	NP_001014819.1	FHA	1..97	CDD:238017	30/97 (31%)
		FHA	<11..87	CDD:224630	27/87 (31%)
		BRCT	99..164	CDD:237994	21/64 (33%)
		NIBRIN_BRCT_II	203..311	CDD:293117	34/109 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	372..716		69/388 (18%)
		Nuclear localization signal. /evidence=ECO:0000250	470..475		0/4 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	729..757		8/32 (25%)
		Nbs1_C	747..809	CDD:285765	6/12 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	793..818
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170579646
Domainoid	1	1.000	55	1.000	Domainoid score	I11141
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	141	1.000	Inparanoid score	I4473
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006929
OrthoInspector	1	1.000	-	-		oto41357
orthoMCL	1	0.900	-	-		OOG6_106244
Panther	1	1.100	-	-	LDO	PTHR12162
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5636
SonicParanoid	1	1.000	-	-		X6655
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.880