DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nbs and H39E23.3

DIOPT Version :9

Sequence 1:	NP_651973.4	Gene:	nbs / 44259	FlyBaseID:	FBgn0261530	Length:	818	Species:	Drosophila melanogaster
Sequence 2:	NP_001024021.1	Gene:	H39E23.3 / 3565355	WormBaseID:	WBGene00044201	Length:	746	Species:	Caenorhabditis elegans

Alignment Length:	480	Identity:	116/480 - (24%)
Similarity:	182/480 - (37%)	Gaps:	102/480 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   321 PTTESVTS--SMAFNSSIIVPNTERHSAQSNATPISELVVPESIECEME------QDASKP---- 373
            |.|||..|  ..........|.||...::..|....|...|::...:.|      ::|.||
Worm   314 PKTESADSEKKAPVKREADKPKTESADSEKKAPTKREADPPKTESADSEKKAPAKREADKPKTES 378

  Fly   374 -HSEDQASLRKRSHASTVDSSDEEKKSTLSKRAKSDIATKLTMKSKNAILLDSSLEEDVTPAPAP 437
             .||.:||.::.:.....:|:|.|||:.:.:.|...       |:::|   ||..:..|.....|
Worm   379 ADSEKKASAKREADKPKTESADSEKKAPVKREADKP-------KTESA---DSEKKAPVKREADP 433

  Fly   438 APVQRVTRQSKAIAEEKSVHPPVPAASKHITRKTKQVFCVDSSDEENENARKPKETPAPTIPSMA 502
            ...:....:.|| ..::...||          ||      :|:|.|.:...|.:..|..|..:.:
Worm   434 PKTESADSEKKA-PTKREADPP----------KT------ESADSEKKAPAKREADPPKTESADS 481

  Fly   503 KKKTEAPVATRISPRLNGKSLATNITNQPADKHAVP---------AKRPVLSVASSDEEDEGDLF 558
            :||  ||......|...  ..|.:....||.:.|.|         .|.||...|...:.:..|
Worm   482 EKK--APAKREADPPKT--ESADSEKKAPAKREADPPKTESADSEKKAPVKREADKPKTESAD-- 540

  Fly   559 QFRKSPQK----PAETVVQPRIAGKGNAPA-RISVVDFLEKSQAQEPAPV-----PPQLES--QS 611
            ..:|:|.|    |.:|   .....:.|||| |.:.....|.:.:::.||.     ||:.||  ..
Worm   541 SEKKAPAKREADPPKT---ESADSEKNAPAKREADKPKTESADSEKKAPAKREADPPKTESADSE 602

  Fly   612 QTQPRKRLRLELLNESDSDDCDNLFNFADSKKKR---------KTQEAQRNDDSTDGLFNFNSER 667
            :..|.||       |:|....::    |||:||.         ||:.|   |..........:::
Worm   603 KKAPAKR-------EADPPKTES----ADSEKKAPAKREADPPKTESA---DSEKKAPVKREADK 653

  Fly   668 P----SDHDDEDSRLTEPFVPETESKKQSKYIVAPRR-DRPK--KVDISGWLSCSRLNDNIKSEI 725
            |    :|.:.:.....|...|:|||....|...|.|. |:||  ..|.....|..|..|..|:|
Worm   654 PKTESADSEKKAPAKREADPPKTESADSEKNAPAKREADKPKTESADSEKKASAKREADPPKTE- 717

  Fly   726 DADSVKMETSIKADPDEEQWLAAMK 750
            .|||.| :..:|.:.|:.:..:|.|
Worm   718 SADSEK-KAPVKREADKPKTESADK 741

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nbs	NP_651973.4	FHA	3..98	CDD:238017
		FHA	<8..99	CDD:224630
		BRCT	115..171	CDD:237994
		NIBRIN_BRCT_II	207..311	CDD:293117
H39E23.3	NP_001024021.1	PTZ00121	<41..737	CDD:173412	114/474 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000