DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ps and NOVA2

DIOPT Version :9

Sequence 1:	NP_001262415.1	Gene:	ps / 44258	FlyBaseID:	FBgn0261552	Length:	780	Species:	Drosophila melanogaster
Sequence 2:	NP_002507.1	Gene:	NOVA2 / 4858	HGNCID:	7887	Length:	492	Species:	Homo sapiens

Alignment Length:	539	Identity:	208/539 - (38%)
Similarity:	289/539 - (53%)	Gaps:	88/539 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   249 ESVCSGIEVEIENNNNNHIHHGETTYHMKILVPAVASGAIIGKGGETIASLQKDTGARVKMSKSH 313
            |.||:        ..:|....||  |.:|:|:|:.|:|:||||||:||..|||:|||.:|:|||.
Human    18 EVVCT--------KRSNTGEEGE--YFLKVLIPSYAAGSIIGKGGQTIVQLQKETGATIKLSKSK 72

  Fly   314 DFYPGTTERVCLITGSTEAIMVVMEFIMDKIRE------KPDLTNKIVDTDSKQTQERDKQVKIL 372
            ||||||||||||:.|:.||:..|..||.:|:||      ||::.| |:...:....:|.||.|::
Human    73 DFYPGTTERVCLVQGTAEALNAVHSFIAEKVREIPQAMTKPEVVN-ILQPQTTMNPDRAKQAKLI 136

  Fly   373 VPNSTAGMIIGKGGAFIKQIKEESGSYVQISQKPTDVSLQERCITIIGDKENNKNACKMILSKIV 437
            |||||||:|||||||.:|.:.|:||::||:||||..::||||.:|:.|:.|....|...|:.|:.
Human   137 VPNSTAGLIIGKGGATVKAVMEQSGAWVQLSQKPEGINLQERVVTVSGEPEQVHKAVSAIVQKVQ 201

  Fly   438 EDPQSGTCLNVSYADVSGPVANFNPTGSPYATNQNAINSSTASLNSTLGTTIG-------GANSA 495
            |||||.:|||:|||:|:|||||.||||||||:..:.:.::.|:..:.....:|       ||..|
Human   202 EDPQSSSCLNISYANVAGPVANSNPTGSPYASPADVLPAAAAASAAAASGLLGPAGLAGVGAFPA 266

  Fly   496 ASLLVNGTGINLSINLGSPNPAPNLAVATQLLEHIKVAMRGSGYSETVTNEVVAALSVLAKYGV- 559
            |....:||.:              ||::|                         ||:.||.||.
Human   267 ALPAFSGTDL--------------LAIST-------------------------ALNTLASYGYN 292

  Fly   560 ---LGMGVGVSHTNGAHSTLGNFLGVTTLDQQTAAAASAATASNVFGAVGQVNLEQYAAAVASAA 621
               ||:|:..:..:|.       |.........||||:|...::..|..|       |.....||
Human   293 TNSLGLGLNSAAASGV-------LAAVAAGANPAAAAAANLLASYAGEAG-------AGPAGGAA 343

  Fly   622 AASRPTQSQLDAAAVQFDPFRHLGSATAPAATPVSLNNNSFGLTATTGTATTAQLGGLSKSPTPG 686
            ....|....|.:.|:......:||:.....|     ......|.|....|..|  ||...:....
Human   344 PPPPPPPGALGSFALAAAANGYLGAGAGGGA-----GGGGGPLVAAAAAAGAA--GGFLTAEKLA 401

  Fly   687 DLSSKDSKNVEVPEVIIGAILGPSGRSLVEIQHVSGANVQISKKGIFAPGTRNRIVTITGQPSAI 751
            ..|:|:...:.|||.::|||||..|::|||.|.::||.:||||||.|.||||||.|||||.|:|.
Human   402 AESAKELVEIAVPENLVGAILGKGGKTLVEYQELTGARIQISKKGEFLPGTRNRRVTITGSPAAT 466

  Fly   752 AKAQYLIEQKINEEETKRA 770
            ..|||||.|::..|:..||
Human   467 QAAQYLISQRVTYEQGVRA 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ps	NP_001262415.1	PCBP_like_KH	275..340	CDD:239089	39/64 (61%)
		PCBP_like_KH	368..433	CDD:239089	34/64 (53%)
		KH-I	696..759	CDD:238053	39/62 (63%)
NOVA2	NP_002507.1	Bipartite nuclear localization signal. /evidence=ECO:0000255	10..26		3/15 (20%)
		KH-I_NOVA_rpt1	33..104	CDD:411863	43/70 (61%)
		KH-I_NOVA_rpt2	131..200	CDD:411864	36/68 (53%)
		KH-I_NOVA_rpt3	409..477	CDD:411807	41/67 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	89	1.000	Domainoid score	I7858
eggNOG	1	0.900	-	-		E1_KOG2191
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	324	1.000	Inparanoid score	I2503
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48040
OrthoDB	1	1.010	-	-		D1167935at2759
OrthoFinder	1	1.000	-	-		FOG0002568
OrthoInspector	1	1.000	-	-		otm42199
orthoMCL	1	0.900	-	-		OOG6_103746
Panther	1	1.100	-	-	LDO	PTHR10288
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5279
SonicParanoid	1	1.000	-	-		X1689
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.870