DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ps and igf2bp3

DIOPT Version :9

Sequence 1:	NP_001262415.1	Gene:	ps / 44258	FlyBaseID:	FBgn0261552	Length:	780	Species:	Drosophila melanogaster
Sequence 2:	XP_009292473.1	Gene:	igf2bp3 / 30967	ZFINID:	ZDB-GENE-000308-1	Length:	607	Species:	Danio rerio

Alignment Length:	668	Identity:	136/668 - (20%)
Similarity:	223/668 - (33%)	Gaps:	220/668 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   161 PHHQMDL--SPLSENGSPNGTPGAQTPTATASGNT--------------------------AAAL 197
            ||.|.::  ..|::.|:........|.|.||..|.                          .:.:
Zfish    90 PHMQWEVLDGLLAQYGTVESCEQVNTDTETAVVNVRYGAKDQAREAMDKLNGFLMENYALKVSYI 154

  Fly   198 ASAAAAAAAATSGGNGSSITNCNSNNSSSSSNAQQQLQLGNYKTNSCWCYGESVCSGIEVEIENN 262
            ....|||.|...||.............|.|..|:.:||
Zfish   155 PDETAAADAPAVGGRRGFNPRGPPRQGSPSLGARPKLQ--------------------------- 192

  Fly   263 NNNHIHHGETTYHMKILVPAVASGAIIGKGGETIASLQKDTGARVKMSKSHDFYPGTTERVCLIT 327
                     :...:::|||....||||||.|.||.::.|.|.:::.:.:..:  .|..|:...:.
Zfish   193 ---------SDVPLRLLVPTQFVGAIIGKEGATIRNITKQTHSKIDIHRKEN--AGAAEKPITVH 246

  Fly   328 GSTEAIMVVMEFIMDKIREKPDLTNKIVDTDSKQTQERDKQVKILVPNSTAGMIIGKGGAFIKQI 392
            .:.|........||: |.:|..:..||.:         :..:|||..|:..|.:|||.|..:|:|
Zfish   247 STPEGCSSACRNIME-IMQKEAIDTKITE---------EIPLKILAHNNFVGRLIGKEGRNLKKI 301

  Fly   393 KEESGSYVQISQKPTDVSL--QERCITIIGDKENNKNACKMILSKIVEDPQSGTCLNVSYADVSG 455
            ::::.:.:.||.. .|::|  .||.||:.|..:....|.:.|:.|:.|..::         ||:.
Zfish   302 EQDTDTKITISPL-QDLTLYNPERTITVKGTLDACAKAEEEIMKKVRESYEN---------DVAA 356

  Fly   456 P--VANFNPTGSPYATNQNAINSSTASLNSTLGTTIGGANSAASLLVNGTGINLSINLGSPNPAP 518
            .  .:|..|     ..|.||           ||...|.|:.         ||:.|:..|.|..|.
Zfish   357 MHLQSNLIP-----GLNLNA-----------LGLFPGAASG---------GISPSVVSGPPPGAQ 396

  Fly   519 NLAVATQLLEHIKVAMRGSGYSETVTNEVVAALSVLAKYGVLGMGVGVSHTNGA----HSTLGNF 579
                              :||                      ...|.|...|.    .|||.:.
Zfish   397 ------------------AGY----------------------QSFGCSGFEGEVPFWASTLSSN 421

  Fly   580 LGVTTLDQQTAAAA-----SAATASNVFGAVGQ--VNLEQYAAAVASAAAA------------SR 625
            .|.|....|..:..     .|.....:.|..||  ..|.::|.|....|.|            |.
Zfish   422 SGCTAFSAQMESETVHLFIPALAVGAIIGKQGQHIKQLSRFAGASIKIAPADGIDAKQRMVIISG 486

  Fly   626 PTQSQLDAAAVQFDPFRHLGSATAPAATPVSLNNNSFGLTATTGTATTAQLGGLSKSPTPGDLSS 690
            |.::|..|....|...:               ..|.||                     |.: ..
Zfish   487 PPEAQFKAQGRIFGKLK---------------EENFFG---------------------PKE-EV 514

  Fly   691 KDSKNVEVPEVIIGAILGPSGRSLVEIQHVSGANVQISKKGIFAPGTRNRIVT-ITGQPSAIAKA 754
            |...:::||....|.::|..|:::.|:|:::.|.|.:.:..  .|...:::|. |||...|...|
Zfish   515 KLEAHIKVPSFAAGRVIGKGGKTVNELQNLTSAEVVVPRDQ--TPDENDQVVVKITGHFYASQLA 577

  Fly   755 QYLIEQKINEEETKRARQ 772
            |..|::.|:  :.:|.:|
Zfish   578 QRKIQEIIS--QVRRQQQ 593

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ps	NP_001262415.1	PCBP_like_KH	275..340	CDD:239089	17/64 (27%)
		PCBP_like_KH	368..433	CDD:239089	21/66 (32%)
		KH-I	696..759	CDD:238053	17/63 (27%)
igf2bp3	XP_009292473.1	RRM1_IGF2BP3	1..77	CDD:241071
		RRM2_IGF2BP3	81..156	CDD:241074	10/65 (15%)
		KH-I	197..260	CDD:238053	17/64 (27%)
		KH-I	278..343	CDD:238053	21/65 (32%)
		KH-I	435..498	CDD:238053	13/62 (21%)
		KH-I	517..582	CDD:238053	17/66 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574634
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840