DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ps and Nova1

DIOPT Version :9

Sequence 1:	NP_001262415.1	Gene:	ps / 44258	FlyBaseID:	FBgn0261552	Length:	780	Species:	Drosophila melanogaster
Sequence 2:	XP_006240131.1	Gene:	Nova1 / 298992	RGDID:	621345	Length:	507	Species:	Rattus norvegicus

Alignment Length:	552	Identity:	233/552 - (42%)
Similarity:	297/552 - (53%)	Gaps:	117/552 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   255 IEVEIENNNNNHIHHGET-TYHMKILVPAVASGAIIGKGGETIASLQKDTGARVKMSKSHDFYPG 318
            :|...|..:....:.||. .|.:|:|:|:.|:|:||||||:||..|||:|||.:|:|||.|||||
  Rat    30 LEAPPEAGSTKRTNTGEDGQYFLKVLIPSYAAGSIIGKGGQTIVQLQKETGATIKLSKSKDFYPG 94

  Fly   319 TTERVCLITGSTEAIMVVMEFIMDKIREKPD------------------------------LTNK 353
            ||||||||.|:.||:..|..||.:||||.|.                              .|.|
  Rat    95 TTERVCLIQGTIEALNAVHGFIAEKIREMPQNVAKTEPVSILQPQTTVNPDRIKQTLPSSPTTTK 159

  Fly   354 IVDTDSKQTQERDKQVKILVPNSTAGMIIGKGGAFIKQIKEESGSYVQISQKPTDVSLQERCITI 418
            ...:| ..|..|..||||:|||||||:|||||||.:|.|.|:||::||:||||..::||||.:|:
  Rat   160 SSPSD-PMTTSRANQVKIIVPNSTAGLIIGKGGATVKAIMEQSGAWVQLSQKPDGINLQERVVTV 223

  Fly   419 IGDKENNKNACKMILSKIVEDPQSGTCLNVSYADVSGPVANFNPTGSPYATNQNAINSSTASLNS 483
            .|:.|.|:.|.::|:.||.||||||:|||:|||:|:|||||.||||||||        :||.:..
  Rat   224 SGEPEQNRKAVELIIQKIQEDPQSGSCLNISYANVTGPVANSNPTGSPYA--------NTAEVLP 280

  Fly   484 TLGTTIGGANSAASLLVNGTGINLSINLGSPNPAPNLAVATQLLEHIKVAMRGSGYSETVTNEVV 548
            |       |.:||.|            ||..|.|...|....|          ||::......:.
  Rat   281 T-------AAAAAGL------------LGHANLAGVAAFPAVL----------SGFTGNDLVAIT 316

  Fly   549 AALSVLAKYG----VLGMGVGVSHTNGAHSTLGNFLGVTTLDQQTAAAASAATASNVFGAVGQVN 609
            :||:.||.||    .||:|                     |.|..|..|.||.|::...|....|
  Rat   317 SALNTLASYGYNLNTLGLG---------------------LSQAAATGALAAAAASANPAAAAAN 360

  Fly   610 LEQYAAAVASAAAASRPTQSQLDAAAVQFDPFRHLGS-ATAPAATPVSLNNNSFGLTATTGTATT 673
            |   .|..||.|:||..|..   ..|..|    .||| |.|.|||     |..||  |.:..|.:
  Rat   361 L---LATYASEASASGSTAG---GTAGTF----ALGSLAAATAAT-----NGYFG--AASPLAAS 408

  Fly   674 AQLGGLSKSPTPGDLSSKDSKNVEVPEVIIGAILGPSGRSLVEIQHVSGANVQISKKGIFAPGTR 738
            |.||  ::..|.|   |||...:.|||.::|||||..|::|||.|.::||.:||||||.|.||||
  Rat   409 AILG--TEKSTDG---SKDVVEIAVPENLVGAILGKGGKTLVEYQELTGARIQISKKGEFVPGTR 468

  Fly   739 NRIVTITGQPSAIAKAQYLIEQKINEEETKRA 770
            ||.|||||.|:|...|||||.|:|..|:..||
  Rat   469 NRKVTITGTPAATQAAQYLITQRITYEQGVRA 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ps	NP_001262415.1	PCBP_like_KH	275..340	CDD:239089	40/64 (63%)
		PCBP_like_KH	368..433	CDD:239089	38/64 (59%)
		KH-I	696..759	CDD:238053	39/62 (63%)
Nova1	XP_006240131.1	KH-I	49..121	CDD:412160	44/71 (62%)
		KH-I	172..241	CDD:412160	39/68 (57%)
		KH-I	422..492	CDD:412160	42/69 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335323
Domainoid	1	1.000	91	1.000	Domainoid score	I7509
eggNOG	1	0.900	-	-		E1_KOG2191
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	331	1.000	Inparanoid score	I2354
OMA	1	1.010	-	-		QHG48040
OrthoDB	1	1.010	-	-		D1167935at2759
OrthoFinder	1	1.000	-	-		FOG0002568
OrthoInspector	1	1.000	-	-		otm46348
orthoMCL	1	0.900	-	-		OOG6_103746
Panther	1	1.100	-	-	LDO	PTHR10288
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1689
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.770