DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ps and Khsrp

DIOPT Version :9

Sequence 1:	NP_001262415.1	Gene:	ps / 44258	FlyBaseID:	FBgn0261552	Length:	780	Species:	Drosophila melanogaster
Sequence 2:	NP_001382025.1	Gene:	Khsrp / 171137	RGDID:	621828	Length:	748	Species:	Rattus norvegicus

Alignment Length:	635	Identity:	132/635 - (20%)
Similarity:	216/635 - (34%)	Gaps:	213/635 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   174 GSPNGTPGA-----------------------QTPTATASGNTAAALASAAAAAAAATSGGNGSS 215
            |.|.|.|||                       |.|.....|....|.|.|...|....:...|.:
  Rat    29 GPPPGPPGAGDRGGGGPGGGGPGGGGASGGPSQPPGGGGPGIRKDAFADAVQRARQIAAKIGGDA 93

  Fly   216 ITNCNSNNSSSSSNAQ-QQLQLGNY-KTNSCWCYGESVCSGIEVEIENNNNNHIH-HGETTYHMK 277
            .|..|:|........| :||:.|:. .:......|:|:.|.:         ..|| ...|:...:
  Rat    94 ATTVNNNTPDFGFGGQKRQLEDGDQPDSKKLASQGDSIGSQL---------GPIHPPPRTSMTEE 149

  Fly   278 ILVPAVASGAIIGKGGETIASLQKDTGARVKMSKSHDFYPGTTERVCLITGSTEAIM---VVMEF 339
            ..||....|.|||:|||.|..:|:|:|.:|::|....   |..||...:||:.|::.   ::::.
  Rat   150 YRVPDGMVGLIIGRGGEQINKIQQDSGCKVQISPDSG---GLPERSVSLTGAPESVQKAKMMLDD 211

  Fly   340 IMDKIREKP-----DLTNKIVDTDSKQTQERDKQVKILVPNSTAGMIIGKGGAFIKQIKEESGSY 399
            |:.:.|..|     |..|   ...:...||      |::|...||::|||||..|||::|.:|..
  Rat   212 IVSRGRGGPPGQFHDNAN---GGQNGTVQE------IMIPAGKAGLVIGKGGETIKQLQERAGVK 267

  Fly   400 VQISQKPTDVSLQERCITIIGDKENNKNACKMILSKIVEDPQSGTCLNVSYADVSGPVANFNPTG 464
            :.:.|..:..:..::.:.||||....:.||:|::..:.|..|.|      :.|
  Rat   268 MILIQDGSQNTNVDKPLRIIGDPYKVQQACEMVMDILRERDQGG------FGD------------ 314

  Fly   465 SPYATNQNAINSSTASLNSTLGTTIGGANSAASLLVNGTGINLSINLGSPNPAPNLAVATQLLEH 529
                             .:..|:.:||            ||::        |.|..:|
  Rat   315 -----------------RNEYGSRVGG------------GIDV--------PVPRHSV------- 335

  Fly   530 IKVAMRGSGYSETVTNEVVAALSVLAKYGVLGMGVGVSHTNGAHSTLGNFLGVTTLDQQTAAAAS 594
                                             ||.:..:......:.|..||....:|......
  Rat   336 ---------------------------------GVVIGRSGEMIKKIQNDAGVRIQFKQDDGTGP 367

  Fly   595 AATASNVFGAVGQVNLEQYAAAVAS---AAAASRPTQSQLDAAAVQFDPFRHLGSATAPAATPVS 656
            ...|.    .:|..:..::||.:.:   .:..|.|.                 |...||...|
  Rat   368 EKIAH----IMGPPDRCEHAARIINDLLQSLRSGPP-----------------GPPGAPGMPP-- 409

  Fly   657 LNNNSFGLTATTGTATTAQLGGLSK-------SPTPGDLSSKDSKNVEVPEVIIGAILGPSGRSL 714
                                ||..:       .|..|:::      ..:|....|.::|..|.::
  Rat   410 --------------------GGRGRGRGQGNWGPPGGEMT------FSIPTHKCGLVIGRGGENV 448

  Fly   715 VEIQHVSGANVQISKKGIFAP-GTRN-RIVTITGQPSAIAKAQYLIEQKI 762
            ..|...:||.|:||::  ..| |..| ::..|.|.|..|..|:.|||:||
  Rat   449 KAINQQTGAFVEISRQ--LPPNGDPNFKLFVIRGSPQQIDHAKQLIEEKI 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ps	NP_001262415.1	PCBP_like_KH	275..340	CDD:239089	21/67 (31%)
		PCBP_like_KH	368..433	CDD:239089	22/64 (34%)
		KH-I	696..759	CDD:238053	19/64 (30%)
Khsrp	NP_001382025.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..148		27/127 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	394..422		8/66 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	498..570
		4 X 12 AA imperfect repeats	572..685
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	588..650
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	659..678
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335321
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840