Protein Alignment ps and Hnrnpk

DIOPT Version :10

• Sequence 1: NP_001262415.1
• Gene: ps / 44258
• FlyBaseID: FBgn0261552
• Length: 780
• Species: Drosophila melanogaster
• Sequence 2: NP_001288269.1
• Gene: Hnrnpk / 15387
• MGIID: 99894
• Length: 464
• Species: Mus musculus
• Alignment Length: 582
• Identity: 114/582 - (19%)
• Similarity: 209/582 - (35%)
• Gaps: 191/582 - (32%)

  Fly   238 NYKTNSCWCYGESVCSGIEVE--IENNNNNHIHHGETTYHMKILVPAVASGAIIGKGGETIASLQ 300
            |.:||.  .:|:.....:|.|  .:.:.|.     :....::||:.:..:||:|||||:.|.:|:
Mouse    12 NTETNG--EFGKRPAEDMEEEQAFKRSRNT-----DEMVELRILLQSKNAGAVIGKGGKNIKALR 69

  Fly   301 KDTGARVKMSKSHDFYPGTTERVCLITGSTEAIMVVMEFIMDKIRE-----KPDLTNKI-VDTDS 359
            .|..|.|.:..|     ...||:..|:...|.|..:::.|:..:.|     .|..|::: :::|:
Mouse    70 TDYNASVSVPDS-----SGPERILSISADIETIGEILKKIIPTLEEGLQLPSPTATSQLPLESDA 129

  Fly   360 KQT--------QERDKQVKILVPNSTAGMIIGKGGAFIKQIKEESGSYVQISQKPTDVSLQERC- 415
            .:.        .:.|.::::|:..|.||.|||..||.||:::|.:.:.:::        .||.|
Mouse   130 VECLNYQHYKGSDFDCELRLLIHQSLAGGIIGVKGAKIKELRENTQTTIKL--------FQECCP 186

  Fly   416 -----ITIIGDKENNKNAC-KMILSKIVEDPQSGTCLNVSYADVSGPVANFNPTGSPYATNQNAI 474
                 :.:||.|.:....| |:||..|.|.|            :.|....::|.   :.......
Mouse   187 HSTDRVVLIGGKPDRVVECIKIILDLISESP------------IKGRAQPYDPN---FYDETYDY 236

  Fly   475 NSSTASLNSTLGTTIG---GANSAASLLVNGTG-----------INLSINLGSPNPAP------- 518
            ...|...:...|..:|   ........:..|.|           .::|...|.|.|.|
Mouse   237 GGFTMMFDDRRGRPVGFPMRGRGGFDRMPPGRGGRPMPPSRRDYDDMSPRRGPPPPPPGRGGRGG 301

  Fly   519 ----NLAV-------ATQLLEHIKVAMRGSGYSETVTNEVVAALSVLAKYGVLGMGVGVSHTNGA 572
                ||.:       ...|:.:.:....|..|.                 |::|
Mouse   302 SRARNLPLPPPPPPRGGDLMAYDRRGRPGDRYD-----------------GMVG----------- 338

  Fly   573 HSTLGNFLGVTTLDQQTAAAASAATASNVFGAVGQVNLEQYAAAVASAAAASRPTQSQLDAAAVQ 637
                  |....|.|                                ||.....|::.|:     .
Mouse   339 ------FSADETWD--------------------------------SAIDTWSPSEWQM-----A 360

  Fly   638 FDPFRHLGSATAPAATPVSLNNNSFGLTATTGTATTAQLGGLSKSPTPGDLSSKDSKNVEVPEVI 702
            ::|                ...:.:..:...|..:...|||    |.       .:..|.:|:.:
Mouse   361 YEP----------------QGGSGYDYSYAGGRGSYGDLGG----PI-------ITTQVTIPKDL 398

  Fly   703 IGAILGPSGRSLVEIQHVSGANVQISKKGIFAPGTRNRIVTITGQPSAIAKAQYLIEQKINE 764
            .|:|:|..|:.:.:|:|.|||:::|.:.   ..|:.:||:||||....|..||||::..:.:
Mouse   399 AGSIIGKGGQRIKQIRHESGASIKIDEP---LEGSEDRIITITGTQDQIQNAQYLLQNSVKQ 457

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ps	NP_001262415.1	KH-I_NOVA_rpt1	274..345	CDD:411863	21/70 (30%)
		KH-I_NOVA_rpt2	367..436	CDD:411864	22/75 (29%)
		KH-I_NOVA_rpt3	694..762	CDD:411807	24/67 (36%)
Hnrnpk	NP_001288269.1	Necessary for interaction with DDX1. /evidence=ECO:0000250	1..276		65/298 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..37		6/26 (23%)
		ROKNT	4..43	CDD:429813	7/37 (19%)
		KH-I_HNRNPK_rpt1	42..105	CDD:411860	20/67 (30%)
		2 X 22 AA approximate repeats	54..421		92/492 (19%)
		5 X 4 AA repeats of G-X-G-G	59..407		83/473 (18%)
		KH-I_HNRNPK_rpt2	144..213	CDD:411861	23/76 (30%)
		Interaction with ZIK1. /evidence=ECO:0000269|PubMed:8910362	209..337		23/159 (14%)
		RNA-binding RGG-box	236..273		5/36 (14%)
		2 X 6 AA approximate repeats	245..329		12/83 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	250..329		11/78 (14%)
		KH-I_HNRNPK_rpt3	387..460	CDD:411862	24/81 (30%)