Protein Alignment ps and Igf2bp1

DIOPT Version :10

• Sequence 1: NP_001262415.1
• Gene: ps / 44258
• FlyBaseID: FBgn0261552
• Length: 780
• Species: Drosophila melanogaster
• Sequence 2: NP_034081.1
• Gene: Igf2bp1 / 140486
• MGIID: 1890357
• Length: 577
• Species: Mus musculus
• Alignment Length: 662
• Identity: 120/662 - (18%)
• Similarity: 205/662 - (30%)
• Gaps: 296/662 - (44%)

  Fly   115 ISHISNISNISNIGNISNSNHSNAAYSLAVHSYQ-------KQIESPA-NPSHVPHHQMDLSPLS 171
            ::....:.|...:...|.:...|..||....:.|       .|:|:.| ..|::|..|:...|
Mouse   101 LAQYGTVENCEQVNTESETAVVNVTYSNREQTRQAIMKLNGHQLENHALKVSYIPDEQITQGP-- 163

  Fly   172 ENGSPNGTPGAQTPTATASGNTAAALASAAAAAAAATSGGNGSSITNCNSNNSSSSSNAQQQLQL 236
            |||...|......|.                         .||.:        ::.:.|:||
Mouse   164 ENGRRGGFGSRGQPR-------------------------QGSPV--------AAGAPAKQQ--- 192

  Fly   237 GNYKTNSCWCYGESVCSGIEVEIENNNNNHIHHGETTYHMKILVPAVASGAIIGKGGETIASLQK 301
                               .|:|.               :::|||....||||||.|.||.::.|
Mouse   193 -------------------PVDIP---------------LRLLVPTQYVGAIIGKEGATIRNITK 223

  Fly   302 DTGARVKMSKSHDFYPGTTERVCLITGSTEAIMVVMEFIMDKIREKPDLTNKIVDTDSKQTQERD 366
            .|.:::.:.:..:  .|..|:...:..:.|......:.|::           |:..::|.|:..|
Mouse   224 QTQSKIDVHRKEN--AGAAEKAISVHSTPEGCSSACKMILE-----------IMHKEAKDTKTAD 275

  Fly   367 K-QVKILVPNSTAGMIIGKGGAFIKQIKEESGSYVQISQKPTDVSL--QERCITIIGDKENNKNA 428
            : .:|||..|:..|.:|||.|..:|::::::.:.:.||.. .|::|  .||.||:.|..||...|
Mouse   276 EVPLKILAHNNFVGRLIGKEGRNLKKVEQDTETKITISSL-QDLTLYNPERTITVKGAIENCCRA 339

  Fly   429 CKMILSKIVEDPQSGTCLNVSYADVSGPVANFNPTGSPYATNQNAINSSTASLNSTLGTTIGGAN 493
            .:.|:.|:.|..::         ||                       :..||.|.|   |.|.|
Mouse   340 EQEIMKKVREAYEN---------DV-----------------------AAMSLQSHL---IPGLN 369

  Fly   494 SAASLLVNGTGINLSINLGSPNPAPNLAVATQLLEHIKVAMRGSGYSETVTNEVVAALSVLAKYG 558
            .||
Mouse   370 LAA-------------------------------------------------------------- 372

  Fly   559 VLGMGVGVSHTNGAHSTLGNFLGVTTLDQQTAAAASAATASNVFGAVGQVNLEQYAAAVASAAAA 623
                             :|.|                                     .||::|.
Mouse   373 -----------------VGLF-------------------------------------PASSSAV 383

  Fly   624 SRPTQSQLDAAAVQFDPFRHLGSATAPAATPVSLNNNSFGLTATTGTATTAQLGGLSKSPTPGDL 688
            ..|..|...||     |:                  :||                 .::|
Mouse   384 PPPPSSVTGAA-----PY------------------SSF-----------------MQAP----- 403

  Fly   689 SSKDSKNVEVPEVIIGAILGPSGRSLVEIQHVSGANVQISKKGIFAPGTRNRIVTITGQPSAIAK 753
             .::...|.:|...:|||:|..|:.:.::...:.|:::|:...  .|.::.|:|.|||.|.|..|
Mouse   404 -EQEMVQVFIPAQAVGAIIGKKGQHIKQLSRFASASIKIAPPE--TPDSKVRMVVITGPPEAQFK 465

  Fly   754 AQYLIEQKINEE 765
            ||..|..|:.||
Mouse   466 AQGRIYGKLKEE 477

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ps	NP_001262415.1	KH-I_NOVA_rpt1	274..345	CDD:411863	18/70 (26%)
		KH-I_NOVA_rpt2	367..436	CDD:411864	23/71 (32%)
		KH-I_NOVA_rpt3	694..762	CDD:411807	21/67 (31%)
Igf2bp1	NP_034081.1	RRM1_IGF2BP1	1..77	CDD:241069
		RRM2_IGF2BP1	81..156	CDD:410037	10/54 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	156..190		9/68 (13%)
		KH-I_IGF2BP1_rpt1	197..272	CDD:411918	20/102 (20%)
		KH-I_IGF2BP1_rpt2	273..369	CDD:411921	34/131 (26%)
		Sufficient for nuclear export. /evidence=ECO:0000250	312..323		4/11 (36%)
		KH-I_IGF2BP1_rpt3	404..479	CDD:411924	24/76 (32%)
		Sufficient for nuclear export. /evidence=ECO:0000250	485..495
		KH-I_IGF2BP1_rpt4	487..562	CDD:411927