DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ps and IGF2BP2

DIOPT Version :9

Sequence 1:	NP_001262415.1	Gene:	ps / 44258	FlyBaseID:	FBgn0261552	Length:	780	Species:	Drosophila melanogaster
Sequence 2:	NP_001278798.1	Gene:	IGF2BP2 / 10644	HGNCID:	28867	Length:	605	Species:	Homo sapiens

Alignment Length:	646	Identity:	135/646 - (20%)
Similarity:	213/646 - (32%)	Gaps:	233/646 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   140 YSLAVHSYQKQIESPANPSHVPHHQMDLSPLSENGSPNGTPG------AQTPTATASGNTAAALA 198
            ||::.....::|:....|.|:....:| ..|::.|:......      ..|.|.||..|...|..
Human    73 YSVSKKLRSRKIQIRNIPPHLQWEVLD-GLLAQYGTVENVEQVFAFSLVNTDTETAVVNVTYATR 136

  Fly   199 SAAAAAAAATSG---GNGSSITNCNSNNSSSSSNAQQQLQLGNYKTNSCWCYGESVCSGIEVEIE 260
            ..|..|....||   .|.|...:...:...||.:..|:.|.|::                    .
Human   137 EEAKIAMEKLSGHQFENYSFKISYIPDEEVSSPSPPQRAQRGDH--------------------S 181

  Fly   261 NNNNNHIHHG-----ETTYHMKILVPAVASGAIIGKGGETIASLQKDTGARVKMSKSHDFYPGTT 320
            :....|...|     :..:.::||||....||||||.|.||.::.|.|.:||.:.:..:  .|..
Human   182 SREQGHAPGGTSQARQIDFPLRILVPTQFVGAIIGKEGLTIKNITKQTQSRVDIHRKEN--SGAA 244

  Fly   321 ERVCLI----TGSTEAIMVVMEFIMDKIREKPDLTNKIVDTDSKQTQERDKQVKILVPNSTAGMI 381
            |:...|    .|::||..:::| ||.|..::..|..:|             .:|||..|...|.:
Human   245 EKPVTIHATPEGTSEACRMILE-IMQKEADETKLAEEI-------------PLKILAHNGLVGRL 295

  Fly   382 IGKGGAFIKQIKEESGSYVQISQKPTDVSL--QERCITIIGDKENNKNACKMILSKIVEDPQSGT 444
            |||.|..:|:|:.|:|:.:.||.. .|:|:  .||.||:.|..|...:|...|:.|:.|..::
Human   296 IGKEGRNLKKIEHETGTKITISSL-QDLSIYNPERTITVKGTVEACASAEIEIMKKLREAFEN-- 357

  Fly   445 CLNVSYADVSGPVANFNPTGSPYATNQNAINSSTASLNSTLGTTIGGANSAASLLVNGTGINLSI 509
                                ...|.||.|             ..|.|.|.:| |.:..||:::..
Human   358 --------------------DMLAVNQQA-------------NLIPGLNLSA-LGIFSTGLSVLS 388

  Fly   510 NLGSPNPAPNLAVATQLLEHIKVAMRGSGYSETVTNEVVAALSVLAKYGVLGMGVGVSHTNGAHS 574
            ....|..||..|.......|       |||..::                      ..|    |
Human   389 PPAGPRGAPPAAPYHPFTTH-------SGYFSSL----------------------YPH----H- 419

  Fly   575 TLGNFLGVTTLDQQTAAAASAATASNVFGAVGQVNLEQYAAAVASAAAASRPTQSQLDAAAVQFD 639
                                                                          ||.
Human   420 --------------------------------------------------------------QFG 422

  Fly   640 PFRHLGSATAPAATPVSLNNNSFGLTATTGTATTAQLGGLSKSPTPGDLSSKDSKNVEVPEVIIG 704
            ||.|               ::|:                          ..::..|:.:|...:|
Human   423 PFPH---------------HHSY--------------------------PEQEIVNLFIPTQAVG 446

  Fly   705 AILGPSGRSLVEIQHVSGANVQISKKGIFAPGTRNRIVTITGQPSAIAKAQYLIEQKINEE 765
            ||:|..|..:.::...:||:::|:...  .|....|:|.|||.|.|..|||..|..|:.||
Human   447 AIIGKKGAHIKQLARFAGASIKIAPAE--GPDVSERMVIITGPPEAQFKAQGRIFGKLKEE 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ps	NP_001262415.1	PCBP_like_KH	275..340	CDD:239089	24/68 (35%)
		PCBP_like_KH	368..433	CDD:239089	24/66 (36%)
		KH-I	696..759	CDD:238053	20/62 (32%)
IGF2BP2	NP_001278798.1	RRM1_IGF2BP2	2..78	CDD:241070	2/4 (50%)
		RRM_SF	82..163	CDD:302621	18/81 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	163..194		7/50 (14%)
		KH-I	202..265	CDD:238053	23/64 (36%)
		KH-I	283..348	CDD:238053	24/65 (37%)
		PCBP_like_KH	436..499	CDD:239089	21/64 (33%)
		KH-I	517..581	CDD:238053
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141627
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840