DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ps and IGF2BP3

DIOPT Version :9

Sequence 1:	NP_001262415.1	Gene:	ps / 44258	FlyBaseID:	FBgn0261552	Length:	780	Species:	Drosophila melanogaster
Sequence 2:	XP_011513391.1	Gene:	IGF2BP3 / 10643	HGNCID:	28868	Length:	584	Species:	Homo sapiens

Alignment Length:	811	Identity:	150/811 - (18%)
Similarity:	268/811 - (33%)	Gaps:	292/811 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MESIMKVAMDKAAEQLIQQFGFDYLQ----------------------QQLQLQHQNQHNSSPQQ 43
            :|||.|.|....:...:.:.|:.::.                      :.::::|     |.|::
Human    18 LESIFKDAKIPVSGPFLVKTGYAFVDCPDESWALKAIEALSGKIELHGKPIEVEH-----SVPKR 77

  Fly    44 PQHQQLEPEN--EHLTYQYQQSKPTHMQQLACNYQPRHSTTTSSPSSTHSLASGGGSSSNSSNSS 106
            .:.::|:..|  .||  |::..|.|.:..|...|                    |...|....::
Human    78 QRIRKLQIRNIPPHL--QWESPKMTVLDSLLVQY--------------------GVVESCEQVNT 120

  Fly   107 SSDSSSINISHISNISNISNIGNISNSNHSNAAYSLAVHSYQKQIESPANPSHVPHHQMDLSPLS 171
            .|:::.:|:::.|.......:..::.....|  ::|.|.....::.:..||...|..:..|.  .
Human   121 DSETAVVNVTYSSKDQARQALDKLNGFQLEN--FTLKVAYIPDEMAAQQNPLQQPRGRRGLG--Q 181

  Fly   172 ENGSPNGTPGAQTPTATASGNTAAALASAAAAAAAATSGGNGSSITNCNSNNSSSSSNAQQQLQL 236
            ...|..|:||:.:
Human   182 RGSSRQGSPGSVS---------------------------------------------------- 194

  Fly   237 GNYKTNSCWCYGESVCSGIEVEIENNNNNHIHHGETTYHMKILVPAVASGAIIGKGGETIASLQK 301
               |...|                            ...:::|||....||||||.|.||.::.|
Human   195 ---KQKPC----------------------------DLPLRLLVPTQFVGAIIGKEGATIRNITK 228

  Fly   302 DTGARVKMSKSHDFYPGTTERVCLITGSTEAIMVVMEFIMDKIREKPDLTNKIVDTDSKQTQERD 366
            .|.:::.:.:..:  .|..|:...|..:.|......:.|::.:.::..        |.|.|:|
Human   229 QTQSKIDVHRKEN--AGAAEKSITILSTPEGTSAACKSILEIMHKEAQ--------DIKFTEE-- 281

  Fly   367 KQVKILVPNSTAGMIIGKGGAFIKQIKEESGSYVQIS--QKPTDVSLQERCITIIGDKENNKNAC 429
            ..:|||..|:..|.:|||.|..:|:|::::.:.:.||  |:.| :...||.||:.|:.|....|.
Human   282 IPLKILAHNNFVGRLIGKEGRNLKKIEQDTDTKITISPLQELT-LYNPERTITVKGNVETCAKAE 345

  Fly   430 KMILSKIVEDPQSGTCLNVSYADVSGPVANFNPTGSPYATNQNAINSSTASLNSTLGTTIGGANS 494
            :.|:.||.|          ||                    :|.|    ||:|..       |:.
Human   346 EEIMKKIRE----------SY--------------------ENDI----ASMNLQ-------AHL 369

  Fly   495 AASLLVNGTGINLSINLGSPNP--APNLAVATQLLEHIKVAMRGSGYSETVTNEV-VAALSVLAK 556
            ...|.:|..|: .....|.|.|  .|..|:.....:..:        |||.|..: :.||||
Human   370 IPGLNLNALGL-FPPTSGMPPPTSGPPSAMTPPYPQFEQ--------SETETVHLFIPALSV--- 422

  Fly   557 YGVLGMGVGVSHTNGAHSTLGNFLGVTTLDQQTAAAASAATASNVFGAVGQ--VNLEQYAAAVAS 619
                          ||                            :.|..||  ..|.::|.|...
Human   423 --------------GA----------------------------IIGKQGQHIKQLSRFAGASIK 445

  Fly   620 AAAASRPTQSQLDAAAVQFDPFRHLGSATAPAATPVSLNNNSFGLTATTGTATTAQLGGLSKSPT 684
            .|.|..|     ||..       .:...|.|...........:|                 |...
Human   446 IAPAEAP-----DAKV-------RMVIITGPPEAQFKAQGRIYG-----------------KIKE 481

  Fly   685 PGDLSSKDSKNVE----VPEVIIGAILGPSGRSLVEIQHVSGANVQISKKGIFAPGTRNRIVT-I 744
            ...:|.|:...:|    ||....|.::|..|:::.|:|::|.|.|.:.:..  .|...:::|. |
Human   482 ENFVSPKEEVKLEAHIRVPSFAAGRVIGKGGKTVNELQNLSSAEVVVPRDQ--TPDENDQVVVKI 544

  Fly   745 TGQPSAIAKAQYLIEQ---KINEEETKRARQ 772
            ||...|...||..|::   ::.:.:.::|.|
Human   545 TGHFYACQVAQRKIQEILTQVKQHQQQKALQ 575

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ps	NP_001262415.1	PCBP_like_KH	275..340	CDD:239089	18/64 (28%)
		PCBP_like_KH	368..433	CDD:239089	22/66 (33%)
		KH-I	696..759	CDD:238053	19/67 (28%)
IGF2BP3	XP_011513391.1	RRM1_IGF2BP3	1..77	CDD:241071	9/63 (14%)
		RRM	<2..>87	CDD:223796	10/73 (14%)
		RRM2_IGF2BP3	81..161	CDD:241074	17/103 (17%)
		KH-I	203..266	CDD:238053	18/64 (28%)
		KH-I	284..349	CDD:238053	22/65 (34%)
		PCBP_like_KH	412..475	CDD:239089	20/119 (17%)
		KH-I	494..559	CDD:238053	19/66 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141635
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840