DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bab2 and fru

DIOPT Version :9

Sequence 1:	NP_523879.2	Gene:	bab2 / 44254	FlyBaseID:	FBgn0025525	Length:	1067	Species:	Drosophila melanogaster
Sequence 2:	NP_001163648.1	Gene:	fru / 42226	FlyBaseID:	FBgn0004652	Length:	960	Species:	Drosophila melanogaster

Alignment Length:	1008	Identity:	234/1008 - (23%)
Similarity:	340/1008 - (33%)	Gaps:	372/1008 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   171 VETKIKTNPETKPPRRKIVPPSGEG--------------QQFCLRWNNYQSNLTNVFDELLQSES 221
            :||.::..|...||....:||:...              |||||||||:.:|||.|...|||.|:
  Fly    70 IETDVRAPPPPLPPPPLPLPPASPSLQISRYNTDQGAMDQQFCLRWNNHPTNLTGVLTSLLQREA 134

  Fly   222 FVDVTLSCEGHSIKAHKMVLSACSPYFQALFYDNPCQHPIIIMRDVSWSDLKALVEFMYKGEINV 286
            ..||||:|||.::|||:.:||||||||:.:|..|...||||.::||.:|::::|::||||||:||
  Fly   135 LCDVTLACEGETVKAHQTILSACSPYFETIFLQNQHPHPIIYLKDVRYSEMRSLLDFMYKGEVNV 199

  Fly   287 CQDQINPLLKVAETLKIRGLAEVSAGRGEGGASALPMSAFDDEDEEEELASATAILQQDGDADPD 351
            .|..:...||.||:|::|||.                   |:.:           |....|.|
  Fly   200 GQSSLPMFLKTAESLQVRGLT-------------------DNNN-----------LNYRSDCD-- 232

  Fly   352 EEMKAKRPRLLPEGVLDLNQRQRKRSRDGSYATPSPSLQGGESEISERGSSGTPGQSQSQ---PL 413
                                    :.||.  |..||:.:|..:.....|.:|....:..:   .|
  Fly   233 ------------------------KLRDS--AASSPTGRGPSNYTGGLGGAGGVADAMRESRDSL 271

  Fly   414 AMTTSTIVRNPFASPNPQTLEGRNSAMNAVANQRKSPAPTATGHSNGNSGAA-----MHSPPGGV 473
            .......:|:.....:..::..|:||..|.|     .|..|...:.||..||     :.:|.||
  Fly   272 RSRCERDLRDELTQRSSSSMSERSSAAAAAA-----AAAAAVAAAGGNVNAAAVALGLTTPTGG- 330

  Fly   474 AVQSALPPHMAAIVPPPPSAMHHHAQQLAAQHQLAHSHAMASALAAAA-AGAGAAGAGGAGSGSG 537
                          ...||.....|...||        |:|:|:|||| ..|.|.|....||..|
  Fly   331 --------------ERSPSVGSASAAAAAA--------AVAAAVAAAANRSASADGCSDRGSERG 373

  Fly   538 ----------------------SGASAPTGG---------------------------------- 546
                                  :..|:.|||
  Fly   374 TLERTDSRDDLLQLDYSNKDNNNSNSSSTGGNNNNNNNNNNNSSSNNNNSSSNRERNNSGERERE 438

  Fly   547 ---------------TGV------------AGSGAGAAVGSHHDDMEIK------------PEIA 572
                           |.|            :.|....::.|.|.|....            |:..
  Fly   439 RERERERDRDRELSTTPVEQLSSSKRRRKNSSSNCDNSLSSSHQDRHYPQDSQANFKSSPVPKTG 503

  Fly   573 EMIREEERA-----------KMIESGGHGGWMGAAAAATGAASVAADSYQYQLQSMWQKCWNTNQ 626
            ....|.|.|           ..:..||.||.:|||:|.:|.:         |..|:.|:..:..|
  Fly   504 GSTSESEDAGGRHDSPLSMTTSVHLGGGGGNVGAASALSGLS---------QSLSIKQELMDAQQ 559

  Fly   627 QNLVQQLRFRERGPLKSWRPEAM----AEAIFSVLKEGLSLSQAARKFDIPYPTFVLYANRVHNM 687
            |   ||.|.........:.|.|.    ||.:.::|.:  ...|||...|.......|..::..|:
  Fly   560 Q---QQHREHHVALPPDYLPSAALKLHAEDMSTLLTQ--HALQAADARDEHNDAKQLQLDQTDNI 619

  Fly   688 LGPSLDGGADPRPKARG-----RPQRILLGMWPEELIRS---------VIKAVVFRDYREIK--- 735
                     |.|.|...     .|.|        ||.|:         ||:.||....||::
  Fly   620 ---------DGRVKCFNIKHDRHPDR--------ELDRNHREHDDDPGVIEEVVVDHVREMEAGN 667

  Fly   736 ----EDMSAHQY----------------------ANGQGHGTYIGGGTTTNGYHSAAAAKLAAQN 774
                |:|....|                      |:|.|...|:.|     ||:.....|
  Fly   668 EHDPEEMKEAAYHATPPKYRRAVVYAPPHPDEEAASGSGSDIYVDG-----GYNCEYKCK----- 722

  Fly   775 AALAPPDAGSPLSSMTETLRRQILSQQQQHQQHHQQQAHHQQQPSHHQQ----QSPHAQSMNMYK 835
                            |...|.|...:|||...| ...||    .||:.    .:..|.|..:..
  Fly   723 ----------------ELNMRAIRCSRQQHMMSH-YSPHH----PHHRSLIDCPAEAAYSPPVAN 766

  Fly   836 SPAYLQRSEIEDQVSAAAAVAAAAAKHQQQQ--------GERRGSENLPDLSALGLMGLPGLNVM 892
            :.|||..:....|:.  .:.....|.||..|        ...:.|.:.|..|..| .|...::|.
  Fly   767 NQAYLASNGAVQQLD--LSTYHGHANHQLHQHPPSATHPSHSQSSPHYPSASGAG-AGAGSVSVS 828

  Fly   893 PSRGSGGGSGGAAPNSAASYARELSRERERDRERERERELSRQYGSQSRGSSSGSGSAKSLTASQ 957
            .: ||..||..:||.|.|:.|                  :|.|..|.|.||:|.:.:.
  Fly   829 IA-GSASGSATSAPASVATSA------------------VSPQPSSSSTGSTSSAAAV------- 867

  Fly   958 RPGAASPYSAAHYAKHQASAYNKRFLE---SLP 987
               ||:..:||:...|... |:..|::   :||
  Fly   868 ---AAAAAAAANRRDHNID-YSTLFVQLSGTLP 896

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bab2	NP_523879.2	BTB	213..309	CDD:279045	49/95 (52%)
		BTB	224..309	CDD:197585	45/84 (54%)
		HTH_psq	645..690	CDD:283007	11/48 (23%)
fru	NP_001163648.1	BTB	126..221	CDD:279045	49/113 (43%)
		BTB	137..221	CDD:197585	45/102 (44%)
		C2H2 Zn finger	901..918	CDD:275368
		C2H2 Zn finger	925..944	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447057
Domainoid	1	1.000	68	1.000	Domainoid score	I9675
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000141
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23110
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.940