DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bab2 and lov

DIOPT Version :9

Sequence 1:	NP_523879.2	Gene:	bab2 / 44254	FlyBaseID:	FBgn0025525	Length:	1067	Species:	Drosophila melanogaster
Sequence 2:	NP_611994.3	Gene:	lov / 38007	FlyBaseID:	FBgn0266129	Length:	1143	Species:	Drosophila melanogaster

Alignment Length:	1158	Identity:	265/1158 - (22%)
Similarity:	390/1158 - (33%)	Gaps:	415/1158 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 KDVETELVKSKAS---PMNDQA--LTPPPRPLTSSEVVGLRDPEHTELRMCLEAKKSRS------ 143
            ||...:|:|.:.|   .|.|.|  ..|..:||.      |..|....:::.|.||...|
  Fly     3 KDAHQKLIKHRQSTKLSMTDFACQAAPVKQPLP------LELPLPLSVQLQLLAKTPTSDHAPMH 61

  Fly   144 -----LPVSPQPQP-NLKLAGSALFEFGQRSSPVETKIKTNPETKPPRRKIVPPSGEGQQFCLRW 202
                 .|.:|.|.| |:..:.||:.|       ..|...:.|.|.|....:..||.....:.|||
  Fly    62 STPPTTPPTPPPLPLNMSQSASAVTE-------AATPENSLPATPPSEGALAVPSAPQDHYSLRW 119

  Fly   203 NNYQSNLTNVFDELLQSESFVDVTLSCEGHSIKAHKMVLSACSPYFQALFYDNPCQHPIIIMRDV 267
            ||:|:::...||.||::::.|||||.|...||:|||||||||||:||.:|.:.||:||:|:::|.
  Fly   120 NNHQNHILRAFDALLKTKTLVDVTLVCAETSIRAHKMVLSACSPFFQRVFAETPCKHPVIVLKDF 184

  Fly   268 SWSDLKALVEFMYKGEINVCQDQINPLLKVAETLKIRGLAEVSAGRGEGGASALP---------- 322
            ....::|:|:|||:|||:|.|.::..|::..|:|::|||.|.|........:|.|
  Fly   185 RGWVVQAIVDFMYRGEISVPQQRLQTLIQAGESLQVRGLVESSVPEHTPTPAASPDDFGMLDTSM 249

  Fly   323 -MSAFDDE-------DEEEEL-----------ASATAIL--------QQDGDADPDEEM------ 354
             .|.|:||       .:..:|           :||.|.|        :.|.|.:.|:|:
  Fly   250 LSSTFEDECPTMVRPSKGGKLLMPSARLFGNASSAIAALGLRRKREQESDRDLESDQELGGSSPM 314

  Fly   355 ---KAKRPRLLPEGV---LDLNQRQ-------------RKRSRDGSYATPSPSLQGGESEIS--- 397
               |..|||.....|   ..||:..             .:..||...|....:.||...:||
  Fly   315 PRRKQARPRRRSGDVPHDFTLNKTDAESLQTVIKHELLERAERDQEEAPDQDNSQGEAEKISSSP 379

  Fly   398 ---------ERGSSGTPGQSQS------------------------------QPLAMTTSTIVRN 423
                     |:.|....|..|.                              :.|..||:.:.|.
  Fly   380 AKTLVERAKEQKSMKEEGSDQPRSLNENHHQLELDDEDDDDQDHEEEEEQDIEELIHTTNELRRQ 444

  Fly   424 PFA--------SPNP------------------QTLEGRNSAMNAVANQRKS------------- 449
            ..|        ||||                  :.:.|.:|:.:..:|...|
  Fly   445 AAAAAANAAAMSPNPSPCLSDGPEDLCTTKKGKELISGPSSSADCESNNNNSSKLQDNNQRIMLS 509

  Fly   450 ----------PAPTA----TGHSNGNSGAAMHSPPG--GVAVQSALPPHMAAIVPPPPSAMHHHA 498
                      |.|||    |..|.||:|.....|||  ...:..:.|.||.|:    .:.||..|
  Fly   510 LKDIRQLNANPNPTAIHTPTSCSGGNNGLLTFPPPGLRPPGLPDSPPCHMEAL----EAQMHAAA 570

  Fly   499 QQLAA-----QHQLAH-SHAMASALAAAAAGA------------GAAGAGGAGSGSGSGASAPTG 545
            ....|     :|...| .|.|..:||||||.|            |......|.:..|.....|.|
  Fly   571 AAAVAAAGSGEHPFHHMEHQMEMSLAAAAAAAAMHQREPRDPRDGRDHNAFASNLLGPMGMPPFG 635

  Fly   546 G-----TGVAGSGAGAAVGSHHDDME-----IKPEIAEMIREE---ERAKMIESGGHGGWMGAAA 597
            |     .|.:|.|.|....:.|:.:|     :..|:.:...:|   |..|...........|...
  Fly   636 GHNGGHPGNSGPGNGCPGQAAHERLEESMNRLSKELGKEFGKEFGKEFGKEFGPASPMSLQGPFN 700

  Fly   598 AATG--------------AASVAADSYQYQLQSMW---------QKCWNTNQQNLVQQLRFRER- 638
            |..|              :|......:.:.|.|..         .|.:|.    |::....|:.
  Fly   701 APDGPPHPPSPLPFPGMSSAMTLTPPHMFGLDSPLGLFPPGIDPGKLYNP----LMEMSDPRDMP 761

  Fly   639 -----------------------GPLKSWRPEAMAEAIFSVLKEGLSLSQAARKFDIPYPTFVLY 680
                                   ||.:||....:.||:..|..:.::.|||:|.|.|||.:.::|
  Fly   762 GGPPPFLKKKMPRPKGQHSAPRGGPPRSWTNTELTEALQHVWNKKMTTSQASRIFGIPYNSLLMY 826

  Fly   681 AN------------RVHNMLGPSLD----------GGADPRPKARGRPQRILLGMWPEELIRSVI 723
            ..            |...:.||.::          ||:....|::.|.::
  Fly   827 VRGKYGKSLKLEQLRKDCISGPPIEMLQMGIGGGSGGSTKNEKSKERKEK--------------- 876

  Fly   724 KAVVFRDYREIKEDMSAHQYANGQGHGTYIGGGTTTNG----YHSAAAAK--------------- 769
                    .:.|..||    :||.|......||..|:|    .||.....
  Fly   877 --------EKDKNSMS----SNGSGGSANSQGGAPTSGSGPMQHSGELGPMGQLDLDLGLPLGPP 929

  Fly   770 ------------LAAQNAALAP-------PD-----AGSPLSSMTETLRRQILSQQQQHQQHHQQ 810
                        |:|.||...|       ||     .|.|||         :|:.....::||..
  Fly   930 GGPRSNSSEPDLLSAPNALFNPFNPQGFYPDFSGGFPGLPLS---------MLNLLPPAERHHAA 985

  Fly   811 QAHHQQQPSHHQQQSPHAQSMNMYKSPAYLQRSEIEDQVSAAAAVAAAAAKHQQQQGERRGSENL 875
            .|.|....|..:.          .||....|.|.:::..|.              .|.....|:.
  Fly   986 AAMHHLGVSMDED----------CKSVGSKQSSSVDEDYSG--------------PGIPLSLEHR 1026

  Fly   876 PDLSALGLMGLPGLNVMPSRGSGG---------GSGGAAPNSAASYARELSRE 919
            .::||.|    |.|.  ||.|..|         .:|.|..|.....|.||.:|
  Fly  1027 REISATG----PPLT--PSNGGTGHDXNLWRDWAAGAANANPMYFPAFELDQE 1073

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bab2	NP_523879.2	BTB	213..309	CDD:279045	48/95 (51%)
		BTB	224..309	CDD:197585	43/84 (51%)
		HTH_psq	645..690	CDD:283007	13/56 (23%)
lov	NP_611994.3	BTB	130..225	CDD:279045	48/94 (51%)
		BTB	141..226	CDD:197585	43/84 (51%)
		HTH_psq	791..834	CDD:283007	12/42 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	59	1.000	Domainoid score	I10615
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	69	1.000	Inparanoid score	I5158
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000141
OrthoInspector	1	1.000	-	-		otm40394
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23110
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	6.060