DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment bab2 and Nacc2

DIOPT Version :9

Sequence 1:	NP_523879.2	Gene:	bab2 / 44254	FlyBaseID:	FBgn0025525	Length:	1067	Species:	Drosophila melanogaster
Sequence 2:	NP_001094003.1	Gene:	Nacc2 / 296583	RGDID:	1309292	Length:	585	Species:	Rattus norvegicus

Alignment Length:	673	Identity:	128/673 - (19%)
Similarity:	217/673 - (32%)	Gaps:	222/673 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   204 NYQSNLTNVFDELLQSESFVDVTLSCEGHSIKAHKMVLSACSPYFQALFYDNPCQHPIIIMRDVS 268
            |:.:.:....:|......:.||::..:|.:.|||:.||:|.|.||:.||..| .:....:...|.
  Rat    11 NFGNTVLGCLNEQRLLGLYCDVSIVVKGQAFKAHRAVLAASSLYFRDLFSGN-SKSAFELPGTVP 74

  Fly   269 WSDLKALVEFMYKGEINVCQDQINPLLKVAETLKIRGLAE--------VSAGRGEGGASALPMSA 325
            .:..:.::.|.|.|::.:...:...::..|..|:|:.:.|        ||:...:...:.:..::
  Rat    75 PACFQQILSFCYTGKLTMAASEQLVVMYTAGFLQIQHIVERGTDLMFKVSSPHCDSQTAMIEDAS 139

  Fly   326 FDDEDEEEELASATAILQQDGDA----------DPDEEMKAKRPRLLPEGVLDLNQRQRKRSRDG 380
            .:.:....:|..|||........          :..|...|..|.|..:..||..      .|||
  Rat   140 SEPQSPCNQLQPATAAYATSPSVPIPLLTRVKHEAMEMPPATGPGLASKRPLDTG------PRDG 198

  Fly   381 -SYATPSPSLQGGESEISERGSSGTPGQSQSQPLAM---------TTSTIVRNPFASPNPQTLEG 435
             :.||               |::||||   :.||.:         :.:|::.:....|.||
  Rat   199 VAVAT---------------GAAGTPG---TAPLKLPRVSYYGVPSLATLIPSIQQVPYPQ---- 241

  Fly   436 RNSAMNAVANQRKSPA----PTA---TGHSNGNS--------------GAAMHSPPGGVAVQSAL 479
                     .:|.||.    ||.   |.:.|.:.              |.......|..|||.
  Rat   242 ---------GERTSPGASSLPTTDSPTSYHNEDEDDDEAYDTMVEEQYGQMYIKATGNYAVQE-- 295

  Fly   480 PPHMAAIVPPPPSAMHHHAQQLAAQHQLAHSHAMASALAAAAAGAGAAGAGGAGSGSGSGASAP- 543
                    .|.|..:...:..|..:..:|...::.|.:....                    .|
  Rat   296 --------KPEPVPLESRSCVLIRRDLVALPASLISQIGYRC--------------------HPK 332

  Fly   544 ---TGGTG-----VAGSGAGAAVG---SHHDDMEIKPEIAEMIRE-----EERAKMIESGGHGGW 592
               .|..|     |||||.....|   :.|....:|.::  ::|.     .:|..:..|.|
  Rat   333 LYSEGDPGEKLELVAGSGVYITRGQLMNCHLCAGVKHKV--LLRRLLATFFDRNTLANSCG---- 391

  Fly   593 MGAAAAATGAASVAADSYQYQLQSMWQKCWNTNQQNLVQQLRFRE------------RGPLKSWR 645
                   ||..|..:|..:..|.|..........||.....:..|            |...|.|.
  Rat   392 -------TGIRSSTSDPSRKPLDSRVLNAVKLYCQNFAPSFKESEMNVIAADMCTNARRVRKRWL 449

  Fly   646 PEAMAEAIFSVLKEGLSL-------SQAARKFDIPYPTFV-------LYANRVH----------N 686
            |:     |.|:|.||:.:       |.|:...|..:|:..       :||.|.:          :
  Rat   450 PK-----IKSMLPEGVEMYRSVMGASAASLPLDPEFPSAASQVFEQRIYAERRNDAATIVALRTD 509

  Fly   687 MLGPSLDGGADPRPKARGRPQRILLGMWPEEL--IRSVIKAVVFRDYREIKEDMSAHQYANGQGH 749
            .:...|...|:|..:|.            ||:  ..|||:.|...:  ::..|..:...|..||:
  Rat   510 AVNVDLSTSANPAFEAN------------EEVDGAGSVIQEVAAPE--QLPADGQSSPQAFEQGN 560

  Fly   750 ------------------GTYIG 754
                              |||.|
  Rat   561 TSSSRPQTPVATATRRPEGTYAG 583

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bab2	NP_523879.2	BTB	213..309	CDD:279045	24/103 (23%)
		BTB	224..309	CDD:197585	23/92 (25%)
		HTH_psq	645..690	CDD:283007	13/68 (19%)
Nacc2	NP_001094003.1	BTB_POZ_BTBD14A_NAC2	1..131	CDD:349598	27/120 (23%)
		PHA03247	<138..260	CDD:223021	31/158 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	238..269		10/43 (23%)
		BEN	370..447	CDD:214981	14/89 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	541..585		8/45 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	74	1.000	Inparanoid score	I5180
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.960