DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment bab2 and ZBTB12

DIOPT Version :9

Sequence 1:	NP_523879.2	Gene:	bab2 / 44254	FlyBaseID:	FBgn0025525	Length:	1067	Species:	Drosophila melanogaster
Sequence 2:	NP_862825.1	Gene:	ZBTB12 / 221527	HGNCID:	19066	Length:	459	Species:	Homo sapiens

Alignment Length:	386	Identity:	82/386 - (21%)
Similarity:	130/386 - (33%)	Gaps:	121/386 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   207 SNLTNVFDELLQSESFVDVTLSCEGHSIKAHKMVLSACSPYFQALFYDNP-------CQHPIIIM 264
            :.|.|: ::|...|.|.|||:..:....:.||::|:||||:.:..|..||       ..|...|:
Human    18 ATLRNM-NQLRAEERFCDVTIVADSLKFRGHKVILAACSPFLRDQFLLNPSSELQVSLMHSARIV 81

  Fly   265 RDVSWSDLKALVEFMYKGEINV---------------CQDQINPLLKVAETLKIRGLAEVSAGRG 314
            .|:..|.....:||..:..:|.               |::.::..::....||..|::|.|.
Human    82 ADLLLSCYTGALEFAVRDIVNYLTAASYLQMEHVVEKCRNALSQFIEPKIGLKEDGVSEASL--- 143

  Fly   315 EGGASALPMSAFDDEDEEEELASATAILQQDGDADPDEEMKAKRPRLLPEGVL-----------D 368
               .|::               |||..|.... ..|....|...|..||..:|           |
Human   144 ---VSSI---------------SATKSLLPPA-RTPKPAPKPPPPPPLPPPLLRPVKLEFPLDED 189

  Fly   369 LNQRQRKRSRDGSYATPSPSLQGGESEISERGSSGTPGQSQSQPLAMTTSTIVRNPFASPNPQTL 433
            |..:..:...|            .:.::|:                   ..||:
Human   190 LELKAEEEDED------------EDEDVSD-------------------ICIVK----------- 212

  Fly   434 EGRNSAMNAVANQRKSPAPTATGHSNGNS-GAAMHSPPGGVAVQSALPPHMAAIVPPPPSAMHHH 497
              ..||:. ||::.|.|.....|...|.| |..:     |...||::||...|    ||..:...
Human   213 --VESALE-VAHRLKPPGGLGGGLGIGGSVGGHL-----GELAQSSVPPSTVA----PPQGVVKA 265

  Fly   498 AQQLAAQHQ----------LAHSHAMASALAAAAAGAGAAGAGGAGSGSGSGASAPTGGTG 548
            ...|:...:          .|...|.:..:.|||....|.||||:....||....|.|.:|
Human   266 CYSLSEDAEGEGLLLIPGGRASVGATSGLVEAAAVAMAARGAGGSLGAGGSRGPLPGGFSG 326

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bab2	NP_523879.2	BTB	213..309	CDD:279045	27/117 (23%)
		BTB	224..309	CDD:197585	24/106 (23%)
		HTH_psq	645..690	CDD:283007
ZBTB12	NP_862825.1	BTB	23..127	CDD:306997	24/104 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	153..179		7/26 (27%)
		C2H2 Zn finger	335..355	CDD:275368
		zf-C2H2	359..381	CDD:306579
		COG5048	<361..>448	CDD:227381
		C2H2 Zn finger	361..381	CDD:275368
		C2H2 Zn finger	389..409	CDD:275368
		C2H2 Zn finger	417..435	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000