DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment bab2 and NACC1

DIOPT Version :9

Sequence 1:	NP_523879.2	Gene:	bab2 / 44254	FlyBaseID:	FBgn0025525	Length:	1067	Species:	Drosophila melanogaster
Sequence 2:	NP_443108.1	Gene:	NACC1 / 112939	HGNCID:	20967	Length:	527	Species:	Homo sapiens

Alignment Length:	505	Identity:	105/505 - (20%)
Similarity:	176/505 - (34%)	Gaps:	154/505 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   204 NYQSNLTNVFDELLQSESFVDVTLSCEGHSIKAHKMVLSACSPYFQALFYDNPCQHPIIIMRDVS 268
            |:.:::....:|......:.||::..:||:.|||:.||:|.|.||:.|| :|.....:.:...|.
Human    11 NFGNSILECLNEQRLQGLYCDVSVVVKGHAFKAHRAVLAASSSYFRDLF-NNSRSAVVELPAAVQ 74

  Fly   269 WSDLKALVEFMYKGEINVCQDQINPLLKVAETLKIRGLAEVSAGRGEGGASALPMSAFDDEDEEE 333
            ....:.::.|.|.|.:::.......|:..|..|:|:.:.|      :|....|.:|:...:.:
Human    75 PQSFQQILSFCYTGRLSMNVGDQFLLMYTAGFLQIQEIME------KGTEFFLKVSSPSCDSQ-- 131

  Fly   334 ELASATAILQQDGDADPDEEMKAKRPRLLPEGVLDLNQRQRKRSRDGSYATPSPSLQGGESEISE 398
                                                          |.:|..:||.: .:|.:::
Human   132 ----------------------------------------------GLHAEEAPSSE-PQSPVAQ 149

  Fly   399 RGSSGTPGQSQSQPLAMTTSTIVRNPFASPNPQTLEGRNSAMNAVANQR-KSPAPTATGHSNGNS 462
              :||.|..|...||.....|           :..|..:.....||.:. .|....|.|..||:.
Human   150 --TSGWPACSTPLPLVSRVKT-----------EQQESDSVQCMPVAKRLWDSGQKEAGGGGNGSR 201

  Fly   463 GAAMHSPPGGVAVQSALPPHMAAIVPPPPSAMHHHAQQLAAQHQLAHSHAMASALAAAAAGA--- 524
            ..|..|.|.    .:|..||.    ||||       ||         :..:|:|..|.||||
Human   202 KMAKFSTPD----LAANRPHQ----PPPP-------QQ---------APVVAAAQPAVAAGAGQP 242

  Fly   525 --GAAGAGGAGSG-SGSGASAPTGGTGVAGSGAGAAVGSHHDDMEIKPEIAEMIREEERAKMIES 586
              |.|.|||..|| |.|..::|    |.:.:....:.||:|::            |:|.    |.
Human   243 AGGVAAAGGVVSGPSTSERTSP----GTSSAYTSDSPGSYHNE------------EDEE----ED 287

  Fly   587 GGHGGWMGAAAAATGAASVAADSYQYQLQSMWQKCWNTNQQNLVQQLRFRERGPLKSWRPEAMAE 651
            ||..|               .|....|:.:|:......|.....:::             ||:.|
Human   288 GGEEG---------------MDEQYRQICNMYTMYSMMNVGQTAEKV-------------EALPE 324

  Fly   652 AIFSVLKEGLSLSQAARKFDIPYPTFVLYANRVHNMLGPSLDGGADPRPK 701
            .:....:..:.:.|.....    |..::  |::.|...|.|....||..|
Human   325 QVAPESRNRIRVRQDLASL----PAELI--NQIGNRCHPKLYDEGDPSEK 368

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bab2	NP_523879.2	BTB	213..309	CDD:279045	25/95 (26%)
		BTB	224..309	CDD:197585	24/84 (29%)
		HTH_psq	645..690	CDD:283007	7/44 (16%)
NACC1	NP_443108.1	BTB_POZ_BTBD14B_NAC1	3..125	CDD:349599	29/120 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	131..153		6/72 (8%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	210..292		35/125 (28%)
		BEN	396..474	CDD:214981
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	80	1.000	Inparanoid score	I5230
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.050