DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cpsf160 and Cpsf1

DIOPT Version :9

Sequence 1:	NP_995833.1	Gene:	Cpsf160 / 44250	FlyBaseID:	FBgn0024698	Length:	1455	Species:	Drosophila melanogaster
Sequence 2:	NP_001157645.1	Gene:	Cpsf1 / 94230	MGIID:	2679722	Length:	1450	Species:	Mus musculus

Alignment Length:	1509	Identity:	674/1509 - (44%)
Similarity:	948/1509 - (62%)	Gaps:	141/1509 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFSMCKQTHSATAVEFSIACRFFNNLDENLVVAGANVLKVYRIAPNVEASQRQKLNPSEMRLAPK 65
            |:::.||.|..|.:||::.|.||||.:.||||||.:.|.|||:  |.:|....|.:.|....|.:
Mouse     1 MYAVYKQAHPPTGLEFTMYCNFFNNSERNLVVAGTSQLYVYRL--NRDAEALTKNDGSTEGKAHR 63

  Fly    66 MRLECLATYTLYGNVMSLQCVSLAGAMRDALLISFKDAKLSVLQHDPDTFALKTLSLHYFEEDDI 130
            .:||.:|:::.:|||||:..|.||||.|||||:|||||||||:::||.|..|||||||||||.::
Mouse    64 EKLELVASFSFFGNVMSMASVQLAGAKRDALLLSFKDAKLSVVEYDPGTHDLKTLSLHYFEEPEL 128

  Fly   131 RGGWTGRYFVPTVRVDPDSRCAVMLVYGKRLVVLPFRKDNSLDEIELADVKPIKKAPTAMVSRTP 195
            |.|:......|.||||||.|||.||:||.||||||||:::..:|.|         .......|:.
Mouse   129 RDGFVQNVHTPRVRVDPDGRCAAMLIYGTRLVVLPFRRESLAEEHE---------GLMGEGQRSS 184

  Fly   196 IMASYLIALRDLDEKIDNVLDIQFLHGYYEPTLLILYEPVRTCPGRIKVRSDTCVLVAISLNIQQ 260
            .:.||:|.:|.||||:.|::|:||||||||||||||:||.:|.|||:.||.|||.:|||||||.|
Mouse   185 FLPSYIIDVRALDEKLLNIIDLQFLHGYYEPTLLILFEPNQTWPGRVAVRQDTCSIVAISLNITQ 249

  Fly   261 RVHPIIWTVNSLPFDCLQVYPIQKPIGGCLVMTVNAVIYLNQSVPPYGVSLNSSADNSTAFPLKP 325
            :|||:||::.||||||.|...:.|||||.::..||:::|||||||||||:|||....:|||||:.
Mouse   250 KVHPVIWSLTSLPFDCTQALAVPKPIGGVVIFAVNSLLYLNQSVPPYGVALNSLTTGTTAFPLRT 314

  Fly   326 QDGVRISLDCANFAFIDVDKLVISLRTGDLYVLTLCVDSMRTVRNFHFHKAAASVLTSCICVLHS 390
            |:||||:||||..|||..||:||||:.|::|||||..|.||:||.|||.||||||||:.:..:..
Mouse   315 QEGVRITLDCAQAAFISYDKMVISLKGGEIYVLTLITDGMRSVRAFHFDKAAASVLTTSMVTMEP 379

  Fly   391 EYIFLGSRLGNSLLLHFTEEDQSTVITLDEVEQQSEQQQRNLQDEDQNLEEIFDVDQLEMAPTQA 455
            .|:||||||||||||.:||          ::::......|...|:::               ..:
Mouse   380 GYLFLGSRLGNSLLLKYTE----------KLQEPPASSVREAADKEE---------------PPS 419

  Fly   456 KSRRIE-------------DE--ELEVYGSGAKASVLQLRKFIFEVCDSLMNVAPINYMCAGERV 505
            |.:|:|             ||  |:|||||.|::.. ||..:.||||||::|:.|......||..
Mouse   420 KKKRVEPAVGWTGGKTVPQDEVDEIEVYGSEAQSGT-QLATYSFEVCDSMLNIGPCANAAVGEPA 483

  Fly   506 EFEEDGVTLRPHAESLQDLKIELVAATGHSKNGALSVFVNCINPQIITSFELDGCLDVWTVF--- 567
            ...|:       .::..:..:|:|..:|:.|||||||....|.||::|:|||.||.|:|||.
Mouse   484 FLSEE-------FQNSPEPDLEIVVCSGYGKNGALSVLQKSIRPQVVTTFELPGCYDMWTVIAPV 541

  Fly   568 ---DDATKKSSRNDQ-------------HDFMLLSQRNSTLVLQTGQEINEIENTGFTVNQPTIF 616
               ::.|.|:...:|             |.|::||:.:||::|||||||.|::.:||....||:|
Mouse   542 RKEEEETPKAESTEQEPSAPKAEEDGRRHGFLILSREDSTMILQTGQEIMELDTSGFATQGPTVF 606

  Fly   617 VGNLGQQRFIVQVTTRHVRLLQGTRLIQNVPIDVGSPVVQVSIADPYVCLRVLNGQVITLALR-E 680
            .||:|..|:||||:...:|||:|...:..:|:|:|:|:||.::|||||.:....|.|....|: :
Mouse   607 AGNIGDNRYIVQVSPLGIRLLEGVNQLHFIPVDLGAPIVQCAVADPYVVIMSAEGHVTMFLLKSD 671

  Fly   681 TRG--TPRLAINKHTISSSPAVVAISAYKDLSGLFTVK----GDDINLTGSSNS-AFGHSFGGYM 738
            :.|  ..|||::|..:.....|:|:..|:|:||:||.:    |....|.|.|.| |.|      :
Mouse   672 SYGGRHHRLALHKPPLHHQSKVIALCLYRDVSGMFTTESRLGGARDELGGRSGSEAEG------L 730

  Fly   739 KAEPNMKVEDEEDLLYGDAGSAFKMNSMADLAKQSKQKNSDWWRR--LLVQAKPSYWLVVARQSG 801
            .:|.:..|:|||::||||:.:.|..:.  :.|::|.|..:|   |  ...:|.|::|.::.|::|
Mouse   731 GSETSPTVDDEEEMLYGDSSALFSPSK--EEARRSSQPPAD---RDPAPFKADPTHWCLLVRENG 790

  Fly   802 TLEIYSMPDMKLVYLVNDVGNGSMVLTDAMEFVPISLTTQ------ENSKAGIVQACMPQHANSP 860
            |:|||.:||.:||:||.:...|..||.|:....|   |||      |.::.|          ..|
Mouse   791 TMEIYQLPDWRLVFLVKNFPVGQRVLVDSSFGQP---TTQGEVRKEEATRQG----------ELP 842

  Fly   861 LPLELSVIGLGLNGERPLLLVRTRVELLIYQVFRYP----KGHLKIRFRKM-DQLNLLDQQPTHI 920
            |..|:.::.||....||.|||....|||||:.|.:.    :|:||:||:|: ..:|..:::|
Mouse   843 LVKEVLLVALGSRQSRPYLLVHVDQELLIYEAFPHDSQLGQGNLKVRFKKVPHNINFREKKP--- 904

  Fly   921 DLDENDEQEEIESYQMQP-----KYVQKLRPFANVGGLSGVMVCGVNPCFVFLTFRGELRIHRLL 980
                ...:::.|....:.     ..|.:.|.|.::.|.|||.:||.:|.::.:|.||.||:|.:.
Mouse   905 ----KPSKKKAEGCSTEEGSGGRGRVARFRYFEDIYGYSGVFICGPSPHWLLVTGRGALRLHPMG 965

  Fly   981 GNGDVRSFAAFNNVNIPNGFLYFDTTYELKISVLPSYLSYDSVWPVRKVPLRCTPRQLVYHRENR 1045
            .:|.:.|||.|:|||.|.|||||:...||:|||||:|||||:.|||||:|||||...:.||.|::
Mouse   966 IDGPIDSFAPFHNVNCPRGFLYFNRQGELRISVLPAYLSYDAPWPVRKIPLRCTAHYVAYHVESK 1030

  Fly  1046 VYCLITQTEEPMTKYYRFNGEDKELSEESRGERFIYPIGSQFEMVLISPETWEIVPDASITFEPW 1110
            ||.:.|.|..|.|:..|..||:||.....|.:|:|:|....|.:.||||.:||.:|:|.|..|.|
Mouse  1031 VYAVATSTNTPCTRIPRMTGEEKEFEAIERDDRYIHPQQEAFSIQLISPVSWEAIPNARIELEEW 1095

  Fly  1111 EHVTAFKIVKLSYEGTRSGLKEYLCIGTNFNYSEDITSRGNIHIYDIIEVVPEPGKPMTKFKIKE 1175
            ||||..|.|.|..|.|.||||.|:..||.....|::|.||.|.|.|:||||||||:|:||.|.|.
Mouse  1096 EHVTCMKTVSLRSEETVSGLKGYVAAGTCLMQGEEVTCRGRILIMDVIEVVPEPGQPLTKNKFKV 1160

  Fly  1176 IFKKEQKGPVSAISDVLGFLVTGLGQKIYIWQLRDGDLIGVAFIDTNIYVHQIITVKSLIFIADV 1240
            :::|||||||:|:....|.||:.:||||::|.||..:|.|:|||||.:|:||:|:||:.|..|||
Mouse  1161 LYEKEQKGPVTALCHCNGHLVSAIGQKIFLWSLRASELTGMAFIDTQLYIHQMISVKNFILAADV 1225

  Fly  1241 YKSISLLRFQEEYRTLSLASRDFNPLEVYGIEFMVDNSNLGFLVTDAERNIIVYMYQPEARESLG 1305
            .|||||||:|||.:||||.|||..|||||.::|||||:.|||||:|.:||::||||.|||:||.|
Mouse  1226 MKSISLLRYQEESKTLSLVSRDAKPLEVYSVDFMVDNAQLGFLVSDRDRNLMVYMYLPEAKESFG 1290

  Fly  1306 GQKLLRKADYHLGQVVNTMFRVQCHQKGLHQ---RQPFLYENKHFVVYGTLDGALGYCLPLPEKV 1367
            |.:|||:||:|:|..|||.:|..|  :|..:   ::..::||||...:.||||.:|..||:.||.
Mouse  1291 GMRLLRRADFHVGAHVNTFWRTPC--RGAAEGPSKKSVVWENKHITWFATLDGGIGLLLPMQEKT 1353

  Fly  1368 YRRFLMLQNVLLSYQEHLCGLNPKEYRTLKSSKKQGINPSRCIIDGDLIWSYRLMANSERNEVAK 1432
            |||.|||||.|.:...|..||||:.:|.|...::...|..|.::||:|:..|..::..||:|:||
Mouse  1354 YRRLLMLQNALTTMLPHHAGLNPRAFRMLHVDRRILQNAVRNVLDGELLNRYLYLSTMERSELAK 1418

  Fly  1433 KIGTRTEEILGDLL 1446
            |||| |.:|.|..|
Mouse  1419 KIGT-TPDITGSRL 1431

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cpsf160	NP_995833.1	SFT1	1..1453	CDD:227490	674/1509 (45%)
		MMS1_N	94..674	CDD:287414	286/613 (47%)
		CPSF_A	1086..1419	CDD:281209	176/335 (53%)
Cpsf1	NP_001157645.1	SFT1	1..1421	CDD:227490	667/1496 (45%)
		MMS1_N	92..672	CDD:287414	288/621 (46%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	404..435		5/45 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	545..569		3/23 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	713..775		22/72 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	899..921		2/28 (7%)
		CPSF_A	1071..1406	CDD:281209	176/336 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850531
Domainoid	1	1.000	546	1.000	Domainoid score	I259
eggNOG	1	0.900	-	-		E1_COG5161
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H40865
Inparanoid	1	1.050	1226	1.000	Inparanoid score	I187
Isobase	1	0.950	-	0	Normalized mean entropy	S5756
OMA	1	1.010	-	-		QHG55418
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004621
OrthoInspector	1	1.000	-	-		oto93811
orthoMCL	1	0.900	-	-		OOG6_103351
Panther	1	1.100	-	-	LDO	PTHR10644
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R190
SonicParanoid	1	1.000	-	-		X3233
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.740