Protein Alignment Cpsf160 and CFT1

DIOPT Version :10

• Sequence 1: NP_995833.1
• Gene: Cpsf160 / 44250
• FlyBaseID: FBgn0024698
• Length: 1455
• Species: Drosophila melanogaster
• Sequence 2: NP_010587.1
• Gene: CFT1 / 851895
• SGDID: S000002709
• Length: 1357
• Species: Saccharomyces cerevisiae
• Alignment Length: 1562
• Identity: 363/1562 - (23%)
• Similarity: 629/1562 - (40%)
• Gaps: 347/1562 - (22%)

  Fly    11 ATAVEFSIACRFFNNLDENLVVAGANVLKVYRIAPNVEASQRQKLNPSEMRLAPKMRLECLATYT 75
            ||.|..|:|..|..:..|.|:|...|:|.|||  |..:.                 :|.....:.
Yeast    10 ATVVSHSLATHFTTSDYEELLVVRTNILSVYR--PTRDG-----------------KLYLTDEFK 55

  Fly    76 LYGNVMSLQCVSLAGAMRDALLISFKDAKLSVLQHDPDTFALKTLSLHYFEEDDIRGGWTGRYFV 140
            .:|.:..:..:....:....||:....||:|:|:.:..|.::.||||||:|     |.:.|:..|
Yeast    56 FHGLITDIGLIPQKDSPLSCLLLCTGVAKISILKFNTLTNSIDTLSLHYYE-----GKFKGKSLV 115

  Fly   141 -----PTVRVDPDSRCAVMLVYGKRLVV-LPFR------------KDNSLDEIELADVKPIKKAP 187
                 .|:|:||.|.||  |::...::. |||.            :|.::|:.||......|...
Yeast   116 ELAKISTLRMDPGSSCA--LLFNNDIIAFLPFHVNKNDDDEEEEDEDENIDDSELIHSMNQKSQG 178

  Fly   188 TAMVS---RTPI-----MASYLIALRDLDEKIDNVLDIQFLHGYYEPTLLILYEPVRTCPGRIKV 244
            |...:   ||.:     ..|.::...:|.|...|::|||||..:.:||:.:||:|.....|...:
Yeast   179 TNTFNKRKRTKLGDKFTAPSVVLVASELYEGAKNIIDIQFLKNFTKPTIALLYQPKLVWAGNTTI 243

  Fly   245 RSDTCVLVAISLNIQ------QRVHPIIWTVNSLPFDCLQVYPIQKPIGGCLVMTVNAVIYL-NQ 302
            .......|.::||||      :.....|..|..||:|...:.|:.   .|.:::..|.:.:| |.
Yeast   244 SKLPTQYVILTLNIQPAESATKIESTTIAFVKELPWDLHTIVPVS---NGAIIVGTNELAFLDNT 305

  Fly   303 SVPPYGVSLNSSAD---------------------NSTAFPL---KPQDG------VRISLDC-A 336
            .|....|.|||.||                     |:|:..:   |.::|      ..:.:|. :
Yeast   306 GVLQSTVLLNSFADKELQKTKIINNSSLEIMFREKNTTSIWIPSSKSKNGGSNNDETLLLMDLKS 370

  Fly   337 NFAFIDVD---KLVISLRTGDLYVLTLCVDSMRTVRNFHFHKAAASVLTSCICVLHSEY------ 392
            |..:|.::   :|:|..   |::.|.:..|.::...|           ..||..|::..
Yeast   371 NIYYIQMEAEGRLLIKF---DIFKLPIVNDLLKENSN-----------PKCITRLNATNSNKNMD 421

  Fly   393 IFLGSRLGNSLLLHFTEEDQSTVITLDEVEQQSEQQQRNLQDEDQNLEEIFDVDQLEMAPTQAKS 457
            :|:|...||:|:|..... :||:.|         ::..|......:|.:|.|.|..||....|.
Yeast   422 LFIGFGSGNALVLRLNNL-KSTIET---------REAHNPSSGTNSLMDINDDDDEEMDDLYAD- 475

  Fly   458 RRIEDEELEVYGSGAKASVLQLRKFIFEVCDSLMNVAPINYMCAGERVEFEEDGVTLRPHAESLQ 522
               |..|..:..:.:|.:|..::.|..|:..||.||.||..:..| :|...:|.|...|:....:
Yeast   476 ---EAPENGLTTNDSKGTVETVQPFDIELLSSLRNVGPITSLTVG-KVSSIDDVVKGLPNPNKNE 536

  Fly   523 DLKIELVAATGHSKNGALSVFVNCINPQIITSFELDGCLDVWT----------VFDDATKKSSRN 577
               ..|||.:|:.....|:|....:.|:|..:.:......:|.          :..|:||  ||:
Yeast   537 ---YSLVATSGNGSGSHLTVIQTSVQPEIELALKFISITQIWNLKIKGRDRYLITTDSTK--SRS 596

  Fly   578 DQHDFMLLSQRNSTLVLQTGQEINEIENTGFTVNQPTIFVGNLGQQRFIVQVTTRHVRLLQGTRL 642
            |      :.:.::...|..|..:..        :..|:::...|:::.|:||||.|: .|..|..
Yeast   597 D------IYESDNNFKLHKGGRLRR--------DATTVYISMFGEEKRIIQVTTNHL-YLYDTHF 646

  Fly   643 IQNVPIDVGSPVVQVSIADPYVCLRVLNGQVITLALRETRGTPRLAINKHTISSSPAVVAISAYK 707
            .:...|.....|:.||:.|||:.:.|..|.:....|.|......|.::...|.:...:.
Yeast   647 RRLTTIKFDYEVIHVSVMDPYILVTVSRGDIKIFELEEKNKRKLLKVDLPEILNEMVIT------ 705

  Fly   708 DLSGLFTVKGDDIN--LTGSSNSAFGHSFGGYMKAEPNM--KVEDEEDLLYGDAGSAFKMNSMAD 768
              |||. :|.:..|  |.|.|.|........::.|:..:  ..:|..|.:       |::|.:..
Yeast   706 --SGLI-LKSNMCNEFLIGLSKSQEEQLLFTFVTADNQIIFFTKDHNDRI-------FQLNGVDQ 760

  Fly   769 LAKQSKQKNSDWWRRLLVQAKPSYWLVVARQSGTLEIYSMPDMKLVYLVNDVGNGSMVLTDAMEF 833
            |.:.                     |.::......||...|.:|.| ::|.:|
Yeast   761 LNES---------------------LYISTYQLGDEIVPDPSIKQV-MINKLG------------ 791

  Fly   834 VPISLTTQENSKAGIVQACMPQHANSPLPLELSVIGLGLNGERPLLLVRTRVELLIYQVFRYPKG 898
                                  |.|....|.:...|    ||             |||..:.|:
Yeast   792 ----------------------HDNKEEYLTILTFG----GE-------------IYQYRKLPQ- 816

  Fly   899 HLKIRFRKMDQLNLLDQQPTHIDL-----DENDEQEEIESYQMQPKYVQKLRPFANVGGLSGVMV 958
             .:.||.:         ..|..||     .:|...:.:.|.:....|      |.:..|.|.:.|
Yeast   817 -RRSRFYR---------NVTRNDLAITGAPDNAYAKGVSSIERIMHY------FPDYNGYSVIFV 865

  Fly   959 CGVNPCFVFLTFRGELRIHRLLGNGDV----------RSFAAFNNVNIPNGFLYFDTTYELKISV 1013
            .|..|   ::..:.:....::...|::          ||....:  :|.|..:|..||
Yeast   866 TGSVP---YILIKEDDSTPKIFKFGNIPLVSVTPWSERSVMCVD--DIKNARVYTLTT------- 918

  Fly  1014 LPSYLSYDSVWPVRKVPLR-----------CTPRQLVYHRENRVYCLITQTEEPMTKYYRFNGED 1067
                   |:::...|:||:           .|.::||||...:::.:......|    |...|||
Yeast   919 -------DNMYYGNKLPLKQIKISNVLDDYKTLQKLVYHERAQLFLVSYCKRVP----YEALGED 972

  Fly  1068 KELSEESRGERFI-------YPIGSQFEMVLISPETWEIVPDASITFEPWEHVTAFKIVKLSYEG 1125
                    ||:.|       :..|.|..::||:|::|:::.  .|.|.....|...:...:....
Yeast   973 --------GEKVIGYDENVPHAEGFQSGILLINPKSWKVID--KIDFPKNSVVNEMRSSMIQINS 1027

  Fly  1126 TRSGLKEYLCIGTNFNYSEDITSRGNIHIYDIIEVVPEPGKPMTKFKIKEIFKKEQKGPVSAISD 1190
            .....:||:..|.....:||....|..||||:||||||||||.|.:|:||||::|..|.||.:.:
Yeast  1028 KTKRKREYIIAGVANATTEDTPPTGAFHIYDVIEVVPEPGKPDTNYKLKEIFQEEVSGTVSTVCE 1092

  Fly  1191 VLGFLVTGLGQKIYIWQLR-DGDLIGVAFIDTNIYVHQIITVKSLIFIADVYKSISLLRFQ-EEY 1253
            |.|..:....||:.:..:: |..:|.|||:|..::|....:..:|:.|.|..:....:.|. |.|
Yeast  1093 VSGRFMISQSQKVLVRDIQEDNSVIPVAFLDIPVFVTDSKSFGNLLIIGDAMQGFQFIGFDAEPY 1157

  Fly  1254 RTLSLASRDFNPLEVYGIEFMVDNSNLGFLVTDAERNIIVYMYQPEARESLGGQKLLRKADYHLG 1318
            |.:|| .|..:..:...:||:|:..::.|..|||:||:.|..|.|:...||.||:|:..:.:.|.
Yeast  1158 RMISL-GRSMSKFQTMSLEFLVNGGDMYFAATDADRNVHVLKYAPDEPNSLSGQRLVHCSSFTLH 1221

  Fly  1319 QVVNTMFRVQCHQKGLHQRQPFLYENKHFVVYGTLDGALGYCLPLPEKVYRRFLMLQNVLLSYQE 1383
            ...:.|..:..:::....:.| .::|    |.|.:||::...:||.|:.|||..::|..::..:.
Yeast  1222 STNSCMMLLPRNEEFGSPQVP-SFQN----VGGQVDGSVFKIVPLSEEKYRRLYVIQQQIIDREL 1281

  Fly  1384 HLCGLNPKEYRTLKSSKKQGINPSRCIIDGDLIWSYRLMANSERNEVAKKIGTRTE-EILGDLLE 1447
            .|.||||:..|......:.| :..|.::|.::|..:..:|...|..:|:|.|.... |...|::.
Yeast  1282 QLGGLNPRMERLANDFYQMG-HSMRPMLDFNVIRRFCGLAIDRRKSIAQKAGRHAHFEAWRDIIN 1345

  Fly  1448 IE 1449
            ||
Yeast  1346 IE 1347

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cpsf160	NP_995833.1	SFT1	1..1453	CDD:227490	363/1562 (23%)
CFT1	NP_010587.1	SFT1	1..1353	CDD:227490	363/1562 (23%)