DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cpsf160 and CPSF160

DIOPT Version :9

Sequence 1:	NP_995833.1	Gene:	Cpsf160 / 44250	FlyBaseID:	FBgn0024698	Length:	1455	Species:	Drosophila melanogaster
Sequence 2:	NP_199979.2	Gene:	CPSF160 / 835240	AraportID:	AT5G51660	Length:	1442	Species:	Arabidopsis thaliana

Alignment Length:	1509	Identity:	454/1509 - (30%)
Similarity:	709/1509 - (46%)	Gaps:	221/1509 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 NLVVAGANVLKVYRIAPNVEASQRQKLNPSEMRLAPK---------MRLECLATYTLYGNVMSLQ 84
            |:|:..||:|:||.:....|.:.::..||   :||.:         :.||.:..|.|:|||.|:.
plant    59 NVVITAANILEVYIVRAQEEGNTQELRNP---KLAKRGGVMDGVYGVSLELVCHYRLHGNVESIA 120

  Fly    85 CVSLAGAM----RDALLISFKDAKLSVLQHDPDTFALKTLSLHYFEEDDIRGGW----TGRYFV- 140
            .:.:.|..    ||:::::|:|||:|||:.|....:|:..|:|.||..|    |    .||...
plant   121 VLPMGGGNSSKGRDSIILTFRDAKISVLEFDDSIHSLRMTSMHCFEGPD----WLHLKRGRESFP 181

  Fly   141 --PTVRVDPDSRCAVMLVYGKRLVVLPFRKDNSLDEIELADVKPIKKAPTAMVSRTPIMASYLIA 203
              |.|:|||..||..:||||.::::|   |.:.:....:.|........|....   :.:||:|.
plant   182 RGPLVKVDPQGRCGGVLVYGLQMIIL---KTSQVGSGLVGDDDAFSSGGTVSAR---VESSYIIN 240

  Fly   204 LRDLDEKIDNVLDIQFLHGYYEPTLLILYEPVRTCPGRIKVRSDTCVLVAISLNIQQRVHPIIWT 268
            ||||:.|  :|.|..|||||.||.::||.|...|..||:..:..||||.|:|:|...:.||:||:
plant   241 LRDLEMK--HVKDFVFLHGYIEPVIVILQEEEHTWAGRVSWKHHTCVLSALSINSTLKQHPVIWS 303

  Fly   269 VNSLPFDCLQVYPIQKPIGGCLVMTVNAVIYLNQSVPPYGVSLN---SSADNSTAFPLKPQDGVR 330
            ..:||.|..::..:..||||.||:..|.:.|.:||. ...::||   ||||:|...   |.....
plant   304 AINLPHDAYKLLAVPSPIGGVLVLCANTIHYHSQSA-SCALALNNYASSADSSQEL---PASNFS 364

  Fly   331 ISLDCANFAFIDVDKLVISLRTGDLYVLTLCVDSMRTVRNFHFHKAAASVLTSCICVLHSEYIFL 395
            :.||.|:..:|..|..::|.::|:|.:|||..|. |.|:.....|:.||||.|.|..:.:...||
plant   365 VELDAAHGTWISNDVALLSTKSGELLLLTLIYDG-RAVQRLDLSKSKASVLASDITSVGNSLFFL 428

  Fly   396 GSRLGNSLLLHFTEEDQSTVITLDEVEQQSEQQQRNLQDEDQNLE-EIFDVDQLEMAPTQAKSRR 459
            |||||:|||:.|:            ...........|:|||:::| |.....:|.|. :......
plant   429 GSRLGDSLLVQFS------------CRSGPAASLPGLRDEDEDIEGEGHQAKRLRMT-SDTFQDT 480

  Fly   460 IEDEELEVYGSGAKASVLQLRKFIFEVCDSLMNVAPINYMCAGERVEFEED--GVTLRPHAESLQ 522
            |.:|||.::||....|....:.|.|.|.|||:||.|:.....|.|:..:.:  ||:        :
plant   481 IGNEELSLFGSTPNNSDSAQKSFSFAVRDSLVNVGPVKDFAYGLRINADANATGVS--------K 537

  Fly   523 DLKIELVAATGHSKNGALSVFVNCINPQIITSFELDGCLDVWTVFD--------DATKKSSRNDQ 579
            ....|||..:||.|||||.|....|.|::||..||.||..:|||:.        |::|.::..|:
plant   538 QSNYELVCCSGHGKNGALCVLRQSIRPEMITEVELPGCKGIWTVYHKSSRGHNADSSKMAADEDE 602

  Fly   580 -HDFMLLSQRNSTLVLQTGQEINEI-ENTGFTVNQPTIFVGNLGQQRFIVQVTTRHVRLLQGTRL 642
             |.::::|....|:||:|...:.|: |:..:.|...||..|||..:|.::||.....|:|.|:.:
plant   603 YHAYLIISLEARTMVLETADLLTEVTESVDYYVQGRTIAAGNLFGRRRVIQVFEHGARILDGSFM 667

  Fly   643 IQNVPIDV----------GSPVVQVSIADPYVCLRVLNGQVITLALRETRGTPRLAINKHTIS-S 696
            .|.:....          .|.|..||||||||.||:.:..:..|.     |.|...    |:| |
plant   668 NQELSFGASNSESNSGSESSTVSSVSIADPYVLLRMTDDSIRLLV-----GDPSTC----TVSIS 723

  Fly   697 SPAVVAISAYK-DLSGLFTVKGDDINLTGSSNSAFGHSFGGYMKAEPNMKVEDEEDLLYGDAGSA 760
            ||:|:..|..| ....|:..||                      .||.::....:..|....|.|
plant   724 SPSVLEGSKRKISACTLYHDKG----------------------PEPWLRKASTDAWLSSGVGEA 766

  Fly   761 FKMNSMADLAKQSKQKNSDWWRRLLVQAKPSYWLVVARQSGTLEIYSMPDMKLVYLVNDVGNGSM 825
                  .|......|...|            .:.||..:||.|||:.:|....|:.|:...:|..
plant   767 ------VDSVDGGPQDQGD------------IYCVVCYESGALEIFDVPSFNCVFSVDKFASGRR 813

  Fly   826 VLTDAMEFVPISLTTQENSKAGIVQACMPQHANSPLPLELSVIGLGLNGERPLLL-VRTRVELLI 889
            .|:|    :||.....|.:|.........:..|:.: :||::.....:..||.|. |.....:|.
plant   814 HLSD----MPIHELEYELNKNSEDNTSSKEIKNTRV-VELAMQRWSGHHTRPFLFAVLADGTILC 873

  Fly   890 YQVFRY---------------------PKGHLKIRFRKMDQLNLLDQQPTHIDLDENDEQEEIES 933
            |..:.:                     ..|..|:|..|.          ..|.||.:..:...:.
plant   874 YHAYLFDGVDSTKAENSLSSENPAALNSSGSSKLRNLKF----------LRIPLDTSTREGTSDG 928

  Fly   934 YQMQPKYVQKLRPFANVGGLSGVMVCGVNPCFVFLTFRGELRIHRLLGNGDVRSFAAFNNVNIPN 998
            ...     |::..|.|:.|..|..:.|..|.:..| ||..||.|..|.:|.:.:|...:|||..:
plant   929 VAS-----QRITMFKNISGHQGFFLSGSRPGWCML-FRERLRFHSQLCDGSIAAFTVLHNVNCNH 987

  Fly   999 GFLYFDTTYELKISVLPSYLSYDSVWPVRKVPLRCTPRQLVYHRENRVYCLITQTEEPMTKYYRF 1063
            ||:|......|||..|||...||:.|||:|:||:.||.|:.|:.|..:|.||  ...|::|  ..
plant   988 GFIYVTAQGVLKICQLPSASIYDNYWPVQKIPLKATPHQVTYYAEKNLYPLI--VSYPVSK--PL 1048

  Fly  1064 NGEDKELSEESRGERF------------IYPIGSQFEMVLISPE----TWEIVPDASITFEPWEH 1112
            |.....|.::..|::.            .|.: .:||:.::.||    .||  ..|.|..:..||
plant  1049 NQVLSSLVDQEAGQQLDNHNMSSDDLQRTYTV-EEFEIQILEPERSGGPWE--TKAKIPMQTSEH 1110

  Fly  1113 VTAFKIVKLSYEGTRSGLKEYLCIGTNFNYSEDITSRGNIHIYDIIEVVPEPGK--PMTKFKIKE 1175
            ....::|.|....|... :..|.:||.:...||:.:||.:.::..       ||  ..::..:.|
plant  1111 ALTVRVVTLLNASTGEN-ETLLAVGTAYVQGEDVAARGRVLLFSF-------GKNGDNSQNVVTE 1167

  Fly  1176 IFKKEQKGPVSAISDVLGFLVTGLGQKIYIWQLRDGDLIGVAFIDT-NIYVHQIITVKSLIFIAD 1239
            ::.:|.||.:||::.:.|.|:...|.||.:.:....:|.||||.|. .:||..:..|||.|.:.|
plant  1168 VYSRELKGAISAVASIQGHLLISSGPKIILHKWNGTELNGVAFFDAPPLYVVSMNVVKSFILLGD 1232

  Fly  1240 VYKSISLLRFQEEYRTLSLASRDFNPLEVYGIEFMVDNSNLGFLVTDAERNIIVYMYQPEARESL 1304
            |:|||..|.::|:...|||.::||..|:.:..||::|.|.|...|:|.::||.|:.|.|:..||.
plant  1233 VHKSIYFLSWKEQGSQLSLLAKDFESLDCFATEFLIDGSTLSLAVSDEQKNIQVFYYAPKMIESW 1297

  Fly  1305 GGQKLLRKADYHLGQVVNTMFRVQCHQKGLHQRQPFLYENKHFVVYGTLDGALGYCLPLPEKVYR 1369
            .|.|||.:|::|:|..|:...|:|....|..:      .|:..:::|||||:.|...||.|..:|
plant  1298 KGLKLLSRAEFHVGAHVSKFLRLQMVSSGADK------INRFALLFGTLDGSFGCIAPLDEVTFR 1356

  Fly  1370 RFLMLQNVLLSYQEHLCGLNPKEYRTLKSSKKQGINPSRCIIDGDLIWSYRLMANSERNEVAKKI 1434
            |...||..|:....|:.||||..:|..:||.|...:....|:|.:|:..|.::...|:.|:|.:|
plant  1357 RLQSLQKKLVDAVPHVAGLNPLAFRQFRSSGKARRSGPDSIVDCELLCHYEMLPLEEQLELAHQI 1421

  Fly  1435 GTRTEEILGDLLEI 1448
            ||....||.||:::
plant  1422 GTTRYSILKDLVDL 1435

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cpsf160	NP_995833.1	SFT1	1..1453	CDD:227490	454/1509 (30%)
		MMS1_N	94..674	CDD:287414	206/612 (34%)
		CPSF_A	1086..1419	CDD:281209	110/339 (32%)
CPSF160	NP_199979.2	SFT1	79..1442	CDD:227490	446/1489 (30%)
CPSF160	NP_199979.2	CPSF_A	1083..1408	CDD:397339	111/340 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	263	1.000	Domainoid score	I468
eggNOG	1	0.900	-	-		E1_COG5161
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H40865
Inparanoid	1	1.050	561	1.000	Inparanoid score	I248
OMA	1	1.010	-	-		QHG55418
OrthoDB	1	1.010	-	-		D360328at2759
OrthoFinder	1	1.000	-	-		FOG0004621
OrthoInspector	1	1.000	-	-		oto3653
orthoMCL	1	0.900	-	-		OOG6_103351
Panther	1	1.100	-	-	LDO	PTHR10644
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3233
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.840