Protein Alignment Cpsf160 and cpsf-1

DIOPT Version :9

• Sequence 1: NP_995833.1
• Gene: Cpsf160 / 44250
• FlyBaseID: FBgn0024698
• Length: 1455
• Species: Drosophila melanogaster
• Sequence 2: NP_500157.2
• Gene: cpsf-1 / 177003
• WormBaseID: WBGene00022301
• Length: 1454
• Species: Caenorhabditis elegans
• Alignment Length: 1552
• Identity: 481/1552 - (30%)
• Similarity: 802/1552 - (51%)
• Gaps: 201/1552 - (12%)

  Fly     1 MFSMCKQTHSATAVEFSIACRFF--NNLDENLVVAGANVLKVYRIAPNVEASQRQKLNPSE--MR 61
            |:...::|..:||:.||...:|.  .|....|:..||..::::|:.|.|      ...|.|  ..
 Worm     1 MYGYLRETDDSTAINFSAYGKFLPGENTGFQLLTIGAKFIRIFRVNPYV------LKEPGEDNEE 59

  Fly    62 LAPKMRLECLATYTLYGNVMSLQCVSLAGAM------RDALLISFKDAKLSVLQHDPDTFALKTL 120
            ...|.:|||:.:..|..     :|.|:|.|.      :|::|::|.|||||::..:.....::|:
 Worm    60 WQQKTKLECMFSCRLLN-----KCHSIAVARVPQLPDQDSILMTFDDAKLSIVSINEKERNMQTI 119

  Fly   121 SLHYFEEDDIRGGWTGRYFVPTVRVDPDSRCAVMLVYGKRLVVLPFRKDNSLDEIELADVKPIKK 185
            |||.||.:.:|.|:...:..|.||.||.:|||..|||||.:.:|||.:::..
 Worm   120 SLHAFENEYLRDGFINHFQPPLVRSDPSNRCAACLVYGKHIAILPFHENSKR------------- 171

  Fly   186 APTAMVSRTPIMASYLIALRDLDEKIDNVLDIQFLHGYYEPTLLILYEPVRTCPGRIKVRSDTCV 250
                       :.||:|.|:.:|.::||:.|:.||.||||||:|.||||::|.|||..||.||..
 Worm   172 -----------IHSYVIPLKQIDPRLDNIADMVFLDGYYEPTILFLYEPIQTTPGRACVRYDTMC 225

  Fly   251 LVAISLNIQQRVHPIIWTVNSLPFDCLQVYPIQKPIGGCLVMTVNAVIYLNQSVPPYGVSLNSSA 315
            ::.:|:||..|...::|...:||.||.|:.||.||:||.||...|.|:||||:|||.|:.|||..
 Worm   226 IMGVSVNIVDRQFAVVWQTANLPMDCSQLLPIPKPLGGALVFGSNTVVYLNQAVPPCGLVLNSCY 290

  Fly   316 DNSTAFPLKPQDGVRISLDCANFAFIDVDKLVISLRTGDLYVLTLCVDS-MRTVRNFHFHKAAAS 379
            |..|.||||....::::|||:...:::..::.:..|.|||::|.|...| ..||::..|.|...:
 Worm   291 DGFTKFPLKDLKHLKMTLDCSTSVYMEDGRIAVGSRDGDLFLLRLMTSSGGGTVKSLEFSKVYET 355

  Fly   380 VLTSCICVLHSEYIFLGSRLGNSLLLHFTEEDQSTVITLDEVEQQSEQQQRNLQDEDQNLEEI-F 443
            .:...:.|....::|:|||||:|.||.:         ||.:..:....::..:.::|....|| .
 Worm   356 SIAYSLTVCAPGHLFVGSRLGDSQLLEY---------TLLKTTRDCAVKRLKIDNKDPAAAEIEL 411

  Fly   444 DVDQLEMAPTQAKSRRIEDEELEVYGSGAKASVLQLRKFIFEVCDSLMNVAPINYMCAGERVEFE 508
            |.|.:|:.....:.::.:|:| ::..|      ||.|:.     |.|.||.|:..||.|
 Worm   412 DEDDMELYGGAIEEQQNDDDE-QIDES------LQFREL-----DRLRNVGPVKSMCVG------ 458

  Fly   509 EDGVTLRPH--AESLQDLK-----IELVAATGHSKNGALSVFVNCINPQIITSFELDGCLDVWTV 566
                  ||:  :..|.|.|     .:||.|:||.|||||.|....:.|:||||..|:|...:|.|
 Worm   459 ------RPNYMSNDLVDAKRRDPVFDLVTASGHGKNGALCVHQRSLRPEIITSSLLEGAEQLWAV 517

  Fly   567 FDDATKKSSRNDQHDFMLLSQRNSTLVLQTGQEINEIENTGFTVNQPTIFVGNLGQQRFIVQVTT 631
                  ....|:.|.::::|:..|||:|:.|:|:.|:|...|...:||:..|.|.|....||||:
 Worm   518 ------GRKENESHKYLIVSRVRSTLILELGEELVELEEQLFVTGEPTVAAGELSQGALAVQVTS 576

  Fly   632 RHVRLLQGTRLIQNVPIDVGSPVVQVSIADPYVCLRVLNGQVITLALRETRGTPRLAINKHTISS 696
            ..:.|:...:.:|.|.||...||:|.||.||||.|...||:   |.|.|....|.:.:.:..||:
 Worm   577 TCIALVTDGQQMQEVHIDSNFPVIQASIVDPYVALLTQNGR---LLLYELVMEPYVQLREVDISA 638

  Fly   697 S------------PAVVAISAYKDLSGLFTVKGDDINLTGSSNSAFGHSFGG----------YMK 739
            :            ..:.:||.|.|.|        :|....::..:.|...||          .||
 Worm   639 TSFATWHATAQNLTQLTSISIYADAS--------EIMKFAAAEKSMGGGGGGDGEVSTAENAMMK 695

  Fly   740 AEPNMKV----EDEEDLLYGDAG-SAFKMNSMADLAKQS-KQKNSDWWRRL---LVQAKP----- 790
            .|.:.:.    .:::|.||||.. :..:.|...:..:.: ||.|:...:||   .:|:..
 Worm   696 KEQHEEAILLHGEDDDFLYGDEDETIMEQNFPVENGEATIKQSNTRKRKRLGHDAIQSSRGGEQS 760

  Fly   791 ------------SYWLVVARQSGTLEIYSMPDMKLVYLVNDVGNGSMVLTDAMEFVPISLTTQEN 843
                        |:||:|:.::|.|.|:|:|:|::||.:....|...:|.|        ||.:|.
 Worm   761 DAIDPTRTFSSISHWLIVSHENGRLSIHSLPEMEVVYQIGRFSNVPELLVD--------LTVEEE 817

  Fly   844 SK-------AGIVQACMP----QHANSPLP------LELSVIGLGLNGERPLLLVRTRVELLIYQ 891
            .|       ....:|.:|    :..|:.:.      ||..::|:|:|...|:|:.....::::|:
 Worm   818 EKERKAKAQQAAKEASVPTDEAEQLNTEMKQLCERVLEAQIVGMGINQAHPILMAIVDEQVVLYE 882

  Fly   892 VFRYPK---GHLKIRFRKMDQLNLLDQQPTHIDLDENDEQEEIESYQMQPKYVQKLRPFANVGGL 953
            :|....   |||.|.|||:.....| :..:|::.|  .::...|......|....:.||..|..:
 Worm   883 MFSSSNPIPGHLGISFRKLPHFICL-RTSSHLNSD--GKRAPFEMKINNGKRFSLIHPFERVSSV 944

  Fly   954 -SGVMVCGVNPCFVFLTFRGELRIHRLLGNGDVRSFAAFNNVNIPNGFLYFDTTY--ELKISVLP 1015
             :|||:.|..|..:.....|.::.|::..:|.:::|..|||.|:.:|.:|. |.:  ||:|:.:.
 Worm   945 NNGVMIVGAVPTLLVYGAWGGMQTHQMTVDGPIKAFTPFNNENVLHGIVYM-TQHKSELRIARMH 1008

  Fly  1016 SYLSYDSVWPVRKVPLRCTPRQLVYHRENRVYCLITQTEEPMTKYYRFNGEDKELSEESRGERFI 1080
            ....|:..:||:|:.:..|...:.|...:.||.:::...:|..|.:....:||:.....:.|.|:
 Worm  1009 PDFDYEMPYPVKKIEVGRTIHHVRYLMNSDVYAVVSSIPKPSNKIWVVMNDDKQEEIHEKDENFV 1073

  Fly  1081 YPIGSQFEMVLISPETWEIVPDASITFEPWEHVTAFKIVKLSYEGTRSGLKEYLCIGTNFNYSED 1145
            .|...::.:.|.|.:.|..||:..|:||..|.|||.:.|.|..|.|.|||:..|.:||..||.|:
 Worm  1074 LPAPPKYTLNLFSSQDWAAVPNTEISFEDMEAVTACEDVALKSESTISGLETLLAMGTVNNYGEE 1138

  Fly  1146 ITSRGNIHIYDIIEVVPEPGKPMTKFKIKEIFKKEQKGPVSAISDVLGFLVTGLGQKIYIWQLRD 1210
            :..||.|.:.::|||||||.:|.:..|||.:|.|||||||:.:..:.|.|:.|:|||::|||.:|
 Worm  1139 VLVRGRIILCEVIEVVPEPDQPTSNRKIKVLFDKEQKGPVTGLCAINGLLLCGMGQKVFIWQFKD 1203

  Fly  1211 GDLIGVAFIDTNIYVHQIITVKSLIFIADVYKSISLLRFQEEYRTLSLASRDFN-----PLEVYG 1270
            .||:|::|:|.:.||:|:.:::::....|..:|:||:||||:.:.:|:||||..     |:   .
 Worm  1204 NDLMGISFLDMHYYVYQLHSLRTIAIACDARESMSLIRFQEDNKAMSIASRDDRKCAQPPM---A 1265

  Fly  1271 IEFMVDNSNLGFLVTDAERNIIVYMYQPEARESLGGQKLLRKADYHLGQVVNTMFRVQCHQKGL- 1334
            .:.:||.:::|||::|...||.::.|.|||.||.||::|..:|..::|..:|...|::.|...|
 Worm  1266 SQLVVDGAHVGFLLSDETGNITMFNYAPEAPESNGGERLTVRAAINIGTNINAFVRLRGHTSLLQ 1330

  Fly  1335 --HQRQPFLYENKHFVVYGTLDGALGYCLPLPEKVYRRFLMLQNVLLSYQEHLCGLNPKEYRTLK 1397
              ::.:....|.:...|:.:|||:.|:..||.||.|||...||..:.|....:.||:.|..|:.|
 Worm  1331 LNNEDEKEAIEQRMTTVFASLDGSFGFVRPLTEKSYRRLHFLQTFIGSVTPQIAGLHIKGSRSAK 1395

  Fly  1398 SSKK--QGINPSRCIIDGDLIWSYRLMANSERNEVAKKIGTRTEEILGDLLEIERLA 1452
            .|:.  .|.| :|.:||||::..|..::..::.::|:::|.....|:.||:::.|:|
 Worm  1396 PSQPIVNGRN-ARNLIDGDVVEQYLHLSLYDKTDLARRLGVGRYHIIDDLMQLRRMA 1451

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cpsf160	NP_995833.1	SFT1	1..1453	CDD:227490	481/1552 (31%)
		MMS1_N	94..674	CDD:287414	207/588 (35%)
		CPSF_A	1086..1419	CDD:281209	131/342 (38%)
cpsf-1	NP_500157.2	SFT1	10..1447	CDD:227490	477/1537 (31%)
		MMS1_N	93..623	CDD:287414	209/595 (35%)
		CPSF_A	1079..1420	CDD:281209	132/344 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167653
Domainoid	1	1.000	352	1.000	Domainoid score	I528
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H40865
Inparanoid	1	1.050	722	1.000	Inparanoid score	I325
Isobase	1	0.950	-	0	Normalized mean entropy	S5756
OMA	1	1.010	-	-		QHG55418
OrthoDB	1	1.010	-	-		D33701at33208
OrthoFinder	1	1.000	-	-		FOG0004621
OrthoInspector	1	1.000	-	-		oto19890
orthoMCL	1	0.900	-	-		OOG6_103351
Panther	1	1.100	-	-	LDO	PTHR10644
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R190
SonicParanoid	1	1.000	-	-		X3233
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	15	14.890