DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sip1 and AT2G42330

DIOPT Version :9

Sequence 1:	NP_001285636.1	Gene:	sip1 / 44238	FlyBaseID:	FBgn0024191	Length:	839	Species:	Drosophila melanogaster
Sequence 2:	NP_001078041.1	Gene:	AT2G42330 / 818834	AraportID:	AT2G42330	Length:	752	Species:	Arabidopsis thaliana

Alignment Length:	860	Identity:	227/860 - (26%)
Similarity:	370/860 - (43%)	Gaps:	163/860 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 RPRGRQSRHQQIYGIWADDSEEESGGEGGTKRRGRAARKPKDYTMPVNF-VAGGIQQAGKKKKKA 87
            :.:.||::...:|| :..:|:..|...||::|:.|  ||    |.||.| .||.|.|..|:.:..
plant     7 KEKRRQTKEDAVYG-FVFESDSNSDDSGGSRRKKR--RK----TKPVKFSSAGNIDQVLKQNRGN 64

  Fly    88 LQADDEKGSQKEGAEADQGEESDDSAASGRPAFGQNDPGSSNSSSEEERPTLSRKQPSTTFQHRS 152
            .:.|                |:||:..   |.                  .|.:|     ...::
plant    65 CKID----------------ENDDTIL---PI------------------ALGKK-----IADKA 87

  Fly   153 HIASERNVGA-WEQHTRGIGAKLLLQMGYEPGKGLGKDLQGISHPVQAHVRKGRGAIGAYG--PE 214
            |:..:.|... :|:.:.|||.|||.:|||: |:||||:.|||..|::..:|.....:| |.  .|
plant    88 HVREKNNKKENFEKFSGGIGMKLLEKMGYK-GRGLGKNQQGIVAPIEVQLRPKNMGMG-YNDFKE 150

  Fly   215 TAASIGGKTNK--------SIKVDEDVREAKEFKDQLNKWRKGSAGGAEPMERQGKRYYYKSVEE 271
            ..|.:....||        .:.|.|:..:.:.     :.|:|          :..::..|.:.||
plant   151 KNAPLFPCLNKVEEKKKSVVVTVSENHGDGRR-----DLWKK----------KNVRKEVYITAEE 200

  Fly   272 VIAKGHTSGHLLSEKLSKKLGNVRVIDMTGPEKRVLSGYHALGQAKITPEETLYDTEATEKGSAP 336
            .:.|....|....:         .:||..||:.||::...     .:..||...|....:
plant   201 FLGKKQEEGFGCDQ---------LIIDKRGPQDRVVNSLR-----NLYAEEKATDANVQQ----- 246

  Fly   337 ACVFAMPELTHNLQLLVSQCEQQIIAIDNQERECSSQQAALESEHRKLEEIVQLER---NHIRTL 398
                  |||.|||:.:|...|..|:..|...|.......:|:.|..|.:..|:.::   :::..:
plant   247 ------PELQHNLRFIVKSLEHGILKTDKDLRNEKGLALSLQQEKEKFKMGVKKQKTLFDNLGYV 305

  Fly   399 EESLERVERLIDNPDLSLPQAERLFRELLVDYAAEFHEFGLADLAAGVIAPLLKRELVQWQPLEN 463
            .|.::|:|..|.:.:|:|......|::|...|..::....|:.:|:.:..||..|....|.||.:
plant   306 AEEIDRIEVEIASGNLTLDSLANRFKDLRSSYPDDYKCCNLSCIASSLALPLFIRMFQGWDPLSD 370

  Fly   464 PTEPLPLIKKWRGMLQQGDAAEQQPRNVFDPYSSLIWAGVMPSFR-SSAAAWQPKEHPPMASLLD 527
            ....:..|..|:.:|:..|     .:::..|||.|:...::|:.| |....|:|::..||..||:
plant   371 AEHGIEAISSWKMLLEVED-----NQSISTPYSQLVSEVILPAVRVSGINTWEPRDPEPMLRLLE 430

  Fly   528 AWAPLLPSWVLDSVLEQLVLPRLVAGVQEWDPLTDTVPIDSWVLPWHAILGSKLEEAVYPQIRSK 592
            .|..:|||.:.:::|..:|||:|...::.|:|..:||||..||.||..:||.|||.| |..||.|
plant   431 TWEKMLPSLIFETILTTVVLPKLSIAIESWEPRLETVPIHFWVHPWLPVLGQKLESA-YQIIRMK 494

  Fly   593 LGIALRAWSPHDRSARAMLTPWQKAFPEEEMQEFLQRYIVPKLQATLGELIINPMHQDLELWQQV 657
            .|..|.||.|.|.|...:|:||:..|.....::.::||||||||..|.|..|||..|:|:.:..|
plant   495 FGNLLDAWHPSDVSVHTILSPWKTVFDAASWEQLMRRYIVPKLQVALQEFQINPADQNLDEFNLV 559

  Fly   658 WEWHELIDPMYMAQLLDRHFFPRWMQVLVVWLNQSPDYAEISRWYTGWKSMLSEPLLREPSVKEH 722
            ..|...:....|..|::|.|||:|:.||..||...|.:.||.:|:.|||....:.|.....::..
plant   560 MGWVSSVPIHLMTDLMERFFFPKWLDVLYHWLCSEPKFDEIMKWFLGWKGTFPQELSANRRIEIQ 624

  Fly   723 LRRALEIMHRASDTLLQPTVTPTPPPPVPPAPVIMMDLIHP------------------------ 763
            .:|.|::...|                     |..|::..|
plant   625 FKRGLDMAREA---------------------VERMEMSQPGARENISYHKAQEQRQSEGRAKVQ 668

  Fly   764 -----PAQLEFKELVSQQCADLGIIFAPLPGRREMGKQIYRVGKLFCYIDRHVCMVSDGSFSNWK 823
                 |.:|.|||.|.....:..::..|.|.|...|.||||.|.:...:|.....:.......|.
plant   669 AQVDDPEELSFKEAVELFAQEKELLLKPKPHRMHNGLQIYRFGNVSVLLDSANSKLLAQEEGRWF 733

  Fly   824 PVSLNHLLERSQTGI 838
            ||.|:.||:...:.:
plant   734 PVDLDSLLKMHYSAV 748

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sip1	NP_001285636.1	TIP_N	3..93	CDD:289242	22/69 (32%)
		G-patch	167..211	CDD:279867	20/43 (47%)
		GCFC	416..685	CDD:285127	93/269 (35%)
AT2G42330	NP_001078041.1	TIP_N	<5..>52	CDD:372123	16/51 (31%)
		G-patch	103..144	CDD:366717	19/41 (46%)
		GCFC	323..587	CDD:369552	93/269 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	185	1.000	Domainoid score	I1002
eggNOG	1	0.900	-	-		E1_KOG2184
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H40813
Inparanoid	1	1.050	334	1.000	Inparanoid score	I669
OMA	1	1.010	-	-		QHG54857
OrthoDB	1	1.010	-	-		D1238995at2759
OrthoFinder	1	1.000	-	-		FOG0004443
OrthoInspector	1	1.000	-	-		otm2917
orthoMCL	1	0.900	-	-		OOG6_103393
Panther	1	1.100	-	-	O	PTHR23329
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3147
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.840