DRSC/TRiP Functional Genomics Resources

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Protein Alignment sip1 and Tfip11

DIOPT Version :9

Sequence 1:NP_001285636.1 Gene:sip1 / 44238 FlyBaseID:FBgn0024191 Length:839 Species:Drosophila melanogaster
Sequence 2:NP_061253.2 Gene:Tfip11 / 54723 MGIID:1930075 Length:838 Species:Mus musculus


Alignment Length:884 Identity:306/884 - (34%)
Similarity:467/884 - (52%) Gaps:115/884 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 DNDYERFEITDYDLDNEFNINRPRGRQSRHQQIYGIWAD-DSEEESGGEGGTKRRGRAARKPKDY 66
            |::.|.|||||:||.||||.||.|..|::.:..||:||: ||:||....||        ::.:||
Mouse    19 DDERENFEITDWDLQNEFNPNRQRHWQTKEEATYGVWAERDSDEERPSFGG--------KRARDY 75

  Fly    67 TMPVNFVAGGIQQAGKKKKKALQAD-DEKGSQKEGAEADQGEESDDSAASGRPAFGQNDPGSSNS 130
            :.||||::.|:::...::..:..:| :||..::|....|.|.:...:..:.:|    :..|.|..
Mouse    76 SAPVNFISAGLKKGAAEEADSEDSDAEEKPVKQEDFPKDLGPKKLKTGGNFKP----SQKGFSGG 136

  Fly   131 SSEEERPTLSRKQPSTTFQHRSHIASERNVGAWEQHTRGIGAKLLLQMGYEPGKGLGKDLQGISH 195
            :.                       |..:.|:||:||:|||.|||.:|||.||:||||:.|||.:
Mouse   137 TK-----------------------SFMDFGSWERHTKGIGQKLLQKMGYVPGRGLGKNAQGIIN 178

  Fly   196 PVQAHVRKGRGAIGAYGPETAASIGGKTNKSIK----VDEDVREAKEFKDQLNKWRKGSAGGAEP 256
            |::|..|||:||:||||.|       :|.:|::    .|.:....:||:.:|::|||..:|    
Mouse   179 PIEAKQRKGKGAVGAYGSE-------RTTQSLQDFPVADSEEEAEEEFQKELSQWRKDPSG---- 232

  Fly   257 MERQGKRYYYKSVEEVIAKGHTSGHLLSEKLSKKLGNVRVIDMTGPEKRVLSGYHALGQAKITPE 321
             .::..:|.||:|||:.|||..|..|.:.:  |:|..|:||||||.|::|...|..:......|:
Mouse   233 -SKKKPKYSYKTVEELKAKGRVSKKLTAPQ--KELSQVKVIDMTGREQKVYYSYSQISHKHSVPD 294

  Fly   322 E---TLYDTEATEKGSAPACVFAMPELTHNLQLLVSQCEQQIIAIDNQERECSSQQAALESEHRK 383
            |   .|.....|....|....||:|||.||||||:.:.||:||..|.|.:.......:|..|..|
Mouse   295 EGVPLLAQLPPTAGKEARMPGFALPELEHNLQLLIERTEQEIIQSDRQLQYERDMVVSLSHELEK 359

  Fly   384 LEEIVQLERNHIRTLEESL---ERVERLID----NPDLSLPQAERLFRELLVDYAAEFHEFGLAD 441
            ..|::..|...|..|.:.|   |..||.:.    :| |:|.:..|:|..|...|..|:.....||
Mouse   360 TAEVLAHEERVISNLSKVLALVEECERRMQPHGADP-LTLDECARIFETLQDKYYEEYRLADRAD 423

  Fly   442 LAAGVIAPLLKRELVQWQPLENPTEPLPLIKKWRGMLQQGDAAEQQPRNV-FDPYSSLIWAGVMP 505
            ||..::.||:|.....|.|||:.:....:|.||:.:|:.........::: .|.:..|:|...||
Mouse   424 LAVAIVYPLVKDYFKDWHPLEDGSYGTQIISKWKSLLENDQLLSHSSQDLSSDAFHRLMWEVWMP 488

  Fly   506 SFRSSAAAWQPKEHPPMASLLDAWAPLLPSWVLDSVLEQLVLPRLVAGVQEWDPLTDTVPIDSWV 570
            ..|:..|.|||:...||...||:||.::|.|:||::|:||:.|:|...|..|:||||||||.||:
Mouse   489 FVRNVVAQWQPRNCEPMVDFLDSWAHIIPVWILDNILDQLIFPKLQKEVDNWNPLTDTVPIHSWI 553

  Fly   571 LPWHAILGSKLEEAVYPQIRSKLGIALRAWSPHDRSARAMLTPWQKAFPEEEMQEFLQRYIVPKL 635
            .||..::.::| |.:|..:||||..||:.|.|.|.||:.:|.||::.......:.|:.|.|||||
Mouse   554 HPWLPLMQARL-EPLYSPVRSKLSSALQKWHPSDASAKLILQPWKEVLTPGSWEAFMLRNIVPKL 617

  Fly   636 QATLGELIINPMHQDLELWQQVWEWHELIDPMYMAQLLDRHFFPRWMQVLVVWLNQSPDYAEISR 700
            ...||||:|||..|.::.:..|.:|..:|....:..||::||||:|:|||..||:.||:|.||::
Mouse   618 GMCLGELVINPHQQHMDAFYWVMDWEGMISVSSLVGLLEKHFFPKWLQVLCSWLSNSPNYEEITK 682

  Fly   701 WYTGWKSMLSEPLLREPSVKEHLRRALEIMHRASDT----LLQPTVTPTPPPPVPPAPVIMMDLI 761
            ||.|||||.|:.:|..||||:....||:||:||..:    .:||.....           :..|.
Mouse   683 WYLGWKSMFSDQVLAHPSVKDKFNEALDIMNRAVSSNVGAYMQPGAREN-----------IAYLT 736

  Fly   762 HPPAQ------------------------------LEFKELVSQQCADLGIIFAPLPGRREMGKQ 796
            |...:                              :.||:|:..:..:..|:|.|:.|:|..|||
Mouse   737 HTERRKDFQYEAMQERREAENMAQRGIGVAASSVPMNFKDLIETKAEEHNIVFMPVIGKRHEGKQ 801

  Fly   797 IYRVGKLFCYIDRHVCMVSDGSFSNWKPVSLNHLLERSQ 835
            :|..|::..||||.|..|.  ....|.|.||..|::.::
Mouse   802 LYTFGRIVIYIDRGVVFVQ--GEKTWVPTSLQSLIDMAK 838

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sip1NP_001285636.1 TIP_N 3..93 CDD:289242 35/91 (38%)
G-patch 167..211 CDD:279867 27/43 (63%)
GCFC 416..685 CDD:285127 103/269 (38%)
Tfip11NP_061253.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..74 27/62 (44%)
Required for interaction with DHX15. /evidence=ECO:0000250 1..51 17/31 (55%)
TIP_N 21..105 CDD:289242 35/91 (38%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 86..137 9/54 (17%)
G-patch 150..194 CDD:279867 27/43 (63%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 192..237 15/56 (27%)
GCFC 398..667 CDD:285127 103/269 (38%)
Nuclear localization signal 701..706 2/4 (50%)
Required for nuclear speckle localization 711..735 6/34 (18%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167847396
Domainoid 1 1.000 220 1.000 Domainoid score I2619
eggNOG 1 0.900 - - E1_KOG2184
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H40813
Inparanoid 1 1.050 515 1.000 Inparanoid score I1287
Isobase 1 0.950 - 0 Normalized mean entropy S4097
OMA 1 1.010 - - QHG54857
OrthoDB 1 1.010 - - D1238995at2759
OrthoFinder 1 1.000 - - FOG0004443
OrthoInspector 1 1.000 - - oto93927
orthoMCL 1 0.900 - - OOG6_103393
Panther 1 1.100 - - LDO PTHR23329
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1931
SonicParanoid 1 1.000 - - X3147
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1716.750

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