Protein Alignment sip1 and ntr1

DIOPT Version :10

• Sequence 1: NP_524725.2
• Gene: sip1 / 44238
• FlyBaseID: FBgn0024191
• Length: 839
• Species: Drosophila melanogaster
• Sequence 2: NP_594091.1
• Gene: ntr1 / 2542910
• PomBaseID: SPAC1486.03C
• Length: 797
• Species: Schizosaccharomyces pombe
• Alignment Length: 939
• Identity: 197/939 - (20%)
• Similarity: 368/939 - (39%)
• Gaps: 261/939 - (27%)

  Fly     4 NDYERFEITDYDLDNEFNINRPRGR-----QSRHQQIYGIWADDSEE--ESGGEGGTKRRGRAAR 61
            |:|.....:..|.|.:..:...|.|     |.:.:.:.||:.::.|:  .:.|.|..:.|    |
pombe     3 NEYVDMNSSSEDSDGDSILEEGRLRPSFRGQQKERDMLGIFGEEDEDGFHNSGIGSARLR----R 63

  Fly    62 KPKDYTMPVNFVAGGIQQAGKKKKKALQADDEKGSQKEGAEADQGEESDDSAASGRPAFGQNDPG 126
            |      .::||                   ||..|   .:|::...:||...:      .:.|.
pombe    64 K------NISFV-------------------EKSEQ---VKANKQVTADDLLEA------HSIPQ 94

  Fly   127 SSNSSSEEERPTLSRKQPSTTFQHRSHIASERNVGAWEQHTRGIGAKLLLQMGYEPGKGLGKDLQ 191
            ..|.:.|                    ::..:|:...:.:|.|.|||:|.:|||:.|:|||.:.:
pombe    95 LKNKNDE--------------------VSQAKNIPKMKFNTTGFGAKMLEKMGYKQGQGLGANAE 139

  Fly   192 GISHPVQAHVRKGRGAIGAYGPETAASIGGKTNKSIKVDEDVREAKEFKDQLNKWRKGSAGGAEP 256
            ||:.|||:.:|..|..:||....|.     |..|......::.::::.|..:.:         :|
pombe   140 GIAEPVQSKLRPERVGLGAVRERTE-----KQRKEAIARGEISDSEDEKHTVKQ---------KP 190

  Fly   257 MERQGKRYYYKSVEEVIAKGHTSGHLLSEKLSKKLGNVRVIDMTGPEKRVLSGYHALGQAKITPE 321
            : |:.|:...||               ||::||.:|:..:       .|.|:
pombe   191 L-REKKKKPLKS---------------SEEISKDMGSYNL-------PRFLA------------- 219

  Fly   322 ETLYDTEATEKGSAPACVFAMPELTHNLQLLVSQCEQQIIAIDNQERECS-----SQQAALESEH 381
             :|.|....:              |..::.:.|..|:  :.::.::...|     |:.|.:|.||
pombe   220 -SLIDASLND--------------TKEIEFVTSNKEE--LGLEGRDMSTSGINQLSRLARVECEH 267

  Fly   382 -----RKLE---EIVQLERNHIRTL--EESLE--RVERLID--------NPDLSLPQAE------ 420
                 ::|:   ..|::|...:.|.  |:|:|  |:|:|:.        :.:.::|:||
pombe   268 HASAWQQLQARRAYVKMELKRVTTEFDEKSVEISRLEKLLGKVMEVKSRSMEFTVPEAEIDVIEK 332

  Fly   421 ------RLFRELLVDYAAEFHEFGLADLAAGVIAPLLKRELVQWQPLENPTEPLPLIKKWRGML- 478
                  .|...|.|:::.....|.|..:|..::|.:|...:..|...::|...|.....|:..|
pombe   333 RLQPLNNLIETLPVEFSEASMHFELDSVAVSILAFVLSEPIKNWDVWKHPYFMLESFLSWKNSLY 397

  Fly   479 -------------------QQGDAAEQQPRNVFDPYSSLIWAGVMPSFRSSAAAWQPKEHPPMAS 524
                               :..|..|.|....::.:...:|   ..........|..::......
pombe   398 SKDFRPKREESSTFMDIDVEFDDELEGQSLTHYESFMMFVW---KKKIGEELKKWIIQDSLKALQ 459

  Fly   525 LLDAWAPLLPSWVLDSVLEQLVLPRLVAGVQEWDPLTDTVPIDS---WVLPWHAILGSKLEEAVY 586
            ||:||.|::|..|.||:::..:||||...|.:|:|.......||   .:.||...| .|..:::.
pombe   460 LLEAWDPVVPEKVKDSLIQDDILPRLKDAVSKWNPKLKLKKNDSLHHCIFPWLPYL-EKHADSLL 523

  Fly   587 PQIRSKLGIALRAWSPHDRSARAMLTPWQKAFPEEEMQEFLQRYIVPKLQATLG-ELIINPMHQD 650
            ..:..:..:.|..|...:.|... .:.|:.||..:.:...|::.|:|||:..:. ||:|:|.:||
pombe   524 QSVLVQFSLILSPWKIKNGSIDD-FSVWRSAFANDALDRLLEKVILPKLEKLMDEELVIDPSNQD 587

  Fly   651 LELWQQVWEWHELIDPMYMAQLLDRHFFPRWMQVLVVWLNQSPDYAEISRWYTGWKSMLSEPLLR 715
            ||::..:..|......|...||...||||:|::.|..||.::|::.|.|.|||.|||:..:.||.
pombe   588 LEIFFIILSWKGSFKAMVFGQLFADHFFPKWLETLYQWLTEAPNFDEASEWYTWWKSVFPKDLLS 652

  Fly   716 EPSVKEHLRRALEIMHRASDTLLQPTVTPTPPPPVPPA--------------------------- 753
            ...:::...:.|::|   ::.|...::|    .|:|.|
pombe   653 NAYIQQGFSKGLDMM---NECLENKSIT----APLPFAKDSTKGVNLQFSKEKHEFTAESDDTTS 710

  Fly   754 ---PVIMMDLIHPPAQLEFKELVSQQCADLGIIFAPLPGRR---EMGKQIYRVGK-------LFC 805
               |::           .|:|||.:.||:..::|.||  ||   ..|..::|:..       :..
pombe   711 YDEPLV-----------SFRELVEEFCAENSLLFVPL--RRSHLSTGSALFRISTQASKARGITV 762

  Fly   806 YIDRHVCMVSDGSFSN---WKPVSLNHLL 831
            |:...:........|.   :.|:..|.:|
pombe   763 YLRNDIIWKKSPGASEDTPYDPIGFNEIL 791

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sip1	NP_524725.2	TIP_N	3..93	CDD:463593	17/95 (18%)
		G-patch	167..211	CDD:396249	21/43 (49%)
		SMC_N	<357..>426	CDD:481474	21/105 (20%)
		GCFC	416..685	CDD:400273	71/304 (23%)
ntr1	NP_594091.1	DUF4670	33..>296	CDD:464815	74/387 (19%)
		G-patch	115..159	CDD:396249	21/43 (49%)
		GCFC	334..622	CDD:400273	68/292 (23%)