DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sip1 and TFIP11

DIOPT Version :9

Sequence 1:	NP_001285636.1	Gene:	sip1 / 44238	FlyBaseID:	FBgn0024191	Length:	839	Species:	Drosophila melanogaster
Sequence 2:	NP_001008697.1	Gene:	TFIP11 / 24144	HGNCID:	17165	Length:	837	Species:	Homo sapiens

Alignment Length:	887	Identity:	306/887 - (34%)
Similarity:	469/887 - (52%)	Gaps:	121/887 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 DNDYERFEITDYDLDNEFNINRPRGRQSRHQQIYGIWAD-DSEEESGGEGGTKRRGRAARKPKDY 66
            |::.|.|||||:||.||||.||.|..|::.:..||:||: ||::|....||        ::.:||
Human    18 DDERENFEITDWDLQNEFNPNRQRHWQTKEEATYGVWAERDSDDERPSFGG--------KRARDY 74

  Fly    67 TMPVNFVAGGIQQAGKKKKKALQADD-EKGSQKEGAEADQGEESDDSAASGRPAFGQNDPGSSNS 130
            :.||||::.|:::...::.:...:|| ||..:::....|.|.....:..:.:|    :..|.:..
Human    75 SAPVNFISAGLKKGAAEEAELEDSDDEEKPVKQDDFPKDFGPRKLKTGGNFKP----SQKGFAGG 135

  Fly   131 SSEEERPTLSRKQPSTTFQHRSHIASERNVGAWEQHTRGIGAKLLLQMGYEPGKGLGKDLQGISH 195
            :.                       |..:.|:||:||:|||.|||.:|||.||:||||:.|||.:
Human   136 TK-----------------------SFMDFGSWERHTKGIGQKLLQKMGYVPGRGLGKNAQGIIN 177

  Fly   196 PVQAHVRKGRGAIGAYGPETAASIGGKTNKSIK----VDEDVREAKEFKDQLNKWRKGSAGGAEP 256
            |::|..|||:||:||||.|       :|.:|::    ||.:....:||:.:|::|||..:|
Human   178 PIEAKQRKGKGAVGAYGSE-------RTTQSMQDFPVVDSEEEAEEEFQKELSQWRKDPSG---- 231

  Fly   257 MERQGKRYYYKSVEEVIAKGHTSGHLLSEKLS---KKLGNVRVIDMTGPEKRVLSGYHALGQAKI 318
             .::..:|.||:|||:.|||.     :|:||:   |:|..|:||||||.|::|...|..:.....
Human   232 -SKKKPKYSYKTVEELKAKGR-----ISKKLTAPQKELSQVKVIDMTGREQKVYYSYSQISHKHN 290

  Fly   319 TPEE--TLYDTEATEKG-SAPACVFAMPELTHNLQLLVSQCEQQIIAIDNQERECSSQQAALESE 380
            .|::  .|...:..:.| .|.|..||:|||.||||||:...||:||..|.|.:........|..|
Human   291 VPDDGLPLQSQQLPQSGKEAKAPGFALPELEHNLQLLIDLTEQEIIQNDRQLQYERDMVVNLFHE 355

  Fly   381 HRKLEEIVQLERNHIRTLEESLERVERL-------IDNPDLSLPQAERLFRELLVDYAAEFHEFG 438
            ..|:.|::..|...|..|.:.||.||..       ..|| |:|.:..|:|..|...|..|:....
Human   356 LEKMTEVLDHEERVISNLSKVLEMVEECERRMQPDCSNP-LTLDECARIFETLQDKYYEEYRMSD 419

  Fly   439 LADLAAGVIAPLLKRELVQWQPLENPTEPLPLIKKWRGMLQQGDAAEQQPRNV-FDPYSSLIWAG 502
            ..|||..::.||:|....:|.||::.|....:|.||:.:|:.........::: .|.:..|||..
Human   420 RVDLAVAIVYPLMKEYFKEWDPLKDCTYGTEIISKWKSLLENDQLLSHGGQDLSADAFHRLIWEV 484

  Fly   503 VMPSFRSSAAAWQPKEHPPMASLLDAWAPLLPSWVLDSVLEQLVLPRLVAGVQEWDPLTDTVPID 567
            .||..|:....|||:...||...||:|..::|.|:||::|:||:.|:|...|:.|:||||||||.
Human   485 WMPFVRNIVTQWQPRNCDPMVDFLDSWVHIIPVWILDNILDQLIFPKLQKEVENWNPLTDTVPIH 549

  Fly   568 SWVLPWHAILGSKLEEAVYPQIRSKLGIALRAWSPHDRSARAMLTPWQKAFPEEEMQEFLQRYIV 632
            ||:.||..::.::| |.:|..|||||..||:.|.|.|.||:.:|.||:..|.....:.|:.:.||
Human   550 SWIHPWLPLMQARL-EPLYSPIRSKLSSALQKWHPSDSSAKLILQPWKDVFTPGSWEAFMVKNIV 613

  Fly   633 PKLQATLGELIINPMHQDLELWQQVWEWHELIDPMYMAQLLDRHFFPRWMQVLVVWLNQSPDYAE 697
            |||...||||:|||..|.::.:..|.:|..:|....:..||::||||:|:|||..||:.||:|.|
Human   614 PKLGMCLGELVINPHQQHMDAFYWVIDWEGMISVSSLVGLLEKHFFPKWLQVLCSWLSNSPNYEE 678

  Fly   698 ISRWYTGWKSMLSEPLLREPSVKEHLRRALEIMHRASDT----LLQPTVTPTPPPPVPPAPVIMM 758
            |::||.|||||.|:.:|..||||:....||:||:||..:    .:||.....           :.
Human   679 ITKWYLGWKSMFSDQVLAHPSVKDKFNEALDIMNRAVSSNVGAYMQPGAREN-----------IA 732

  Fly   759 DLIHPPAQ------------------------------LEFKELVSQQCADLGIIFAPLPGRREM 793
            .|.|...:                              :.||:|:..:..:..|:|.|:.|:|..
Human   733 YLTHTERRKDFQYEAMQERREAENMAQRGIGVAASSVPMNFKDLIETKAEEHNIVFMPVIGKRHE 797

  Fly   794 GKQIYRVGKLFCYIDRHVCMVSDGSFSNWKPVSLNHLLERSQ 835
            |||:|..|::..||||.|..|.  ....|.|.||..|::.::
Human   798 GKQLYTFGRIVIYIDRGVVFVQ--GEKTWVPTSLQSLIDMAK 837

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sip1	NP_001285636.1	TIP_N	3..93	CDD:289242	35/91 (38%)
		G-patch	167..211	CDD:279867	27/43 (63%)
		GCFC	416..685	CDD:285127	102/269 (38%)
TFIP11	NP_001008697.1	Required for interaction with DHX15. /evidence=ECO:0000269\|PubMed:19103666	1..50		17/31 (55%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21		1/2 (50%)
		TIP_N	23..104	CDD:372123	34/88 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	53..72		7/26 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	85..133		8/51 (16%)
		G-patch	149..191	CDD:366717	26/41 (63%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	179..236		22/68 (32%)
		GCFC	397..666	CDD:369552	102/269 (38%)
		Nuclear localization signal. /evidence=ECO:0000250	700..705		2/4 (50%)
		Required for nuclear speckle localization. /evidence=ECO:0000250	710..734		6/34 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156994
Domainoid	1	1.000	218	1.000	Domainoid score	I2665
eggNOG	1	0.900	-	-		E1_KOG2184
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H40813
Inparanoid	1	1.050	514	1.000	Inparanoid score	I1316
Isobase	1	0.950	-	0	Normalized mean entropy	S4097
OMA	1	1.010	-	-		QHG54857
OrthoDB	1	1.010	-	-		D1238995at2759
OrthoFinder	1	1.000	-	-		FOG0004443
OrthoInspector	1	1.000	-	-		oto90344
orthoMCL	1	0.900	-	-		OOG6_103393
Panther	1	1.100	-	-	LDO	PTHR23329
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1931
SonicParanoid	1	1.000	-	-		X3147
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750