Protein Alignment sip1 and stip-1

DIOPT Version :9

• Sequence 1: NP_001285636.1
• Gene: sip1 / 44238
• FlyBaseID: FBgn0024191
• Length: 839
• Species: Drosophila melanogaster
• Sequence 2: NP_496226.2
• Gene: stip-1 / 174600
• WormBaseID: WBGene00007412
• Length: 830
• Species: Caenorhabditis elegans
• Alignment Length: 898
• Identity: 283/898 - (31%)
• Similarity: 444/898 - (49%)
• Gaps: 135/898 - (15%)

  Fly     1 MSDND-YERFEITDYDLDNEFNINRPRGR---QSRHQQIYGIWADDSEEESGGEGGTKRRGRAAR 61
            |.|:| .|.|||.|.||:...|   |.||   |::.|..||::|.||:::...:|.:  ||...:
 Worm     1 MEDDDGRESFEINDMDLEYAMN---PGGRRRFQNKDQATYGVFAPDSDDDDDEQGTS--RGPYKK 60

  Fly    62 KPKDYTMPVNFVAGGIQQAGKKKKKALQADD------EKGSQKEGAEADQGEESDDSAASGRPAF 120
            :.| .:.|::||:|||||..|     :..||      ..|.:|:..|.|:|....|.....:.|.
 Worm    61 RSK-ISAPMSFVSGGIQQGNK-----IDKDDPASLNLNLGGEKKPKEDDEGSIQIDFDKRTKKAP 119

  Fly   121 GQND----PGSSNSSSEEERPTLSRKQPSTTFQHRSHIASERN-VGAWEQHTRGIG-----AKLL 175
            .||.    .|..:|:                    :|.|::.| .|:|   .||.|     .|::
 Worm   120 KQNGAQVFAGMRSSA--------------------NHGAADINQFGSW---MRGDGNSNKIMKMM 161

  Fly   176 LQMGYEPGKGLGKDLQGISHPVQAHVRKGRGAIGAYGPETAASIGGKTNKSIKVDEDVREAKE-- 238
            ..|||:||:|||...|||..||||.:||||||:||||.|:.|: |.|..:| ..|...|.|:|
 Worm   162 QAMGYKPGEGLGAQGQGIVEPVQAQLRKGRGAVGAYGKESTAT-GPKFGES-AADAQKRMAQEGT 224

  Fly   239 ----FKDQLNK--------WRKGSAGGAEPMERQGKRYYYKSVEEVIAKGHTSGHLLSEKLSKKL 291
                ..|...|        |:|.          |..:..|:::|:|:.:|.::....|.:.|::.
 Worm   225 SSRPTNDDQEKSGLKIKGSWKKS----------QTVKTKYRTIEDVMEEGMSASRPASHQQSQQY 279

  Fly   292 GNVRVIDMTGPEKRVLSGYHALGQAKITPEETLYDTEATEKGSAPACVFAMPELTHNLQLLVSQC 356
            .|::||||||.::::.|||.:......:..:|:.|.|.|        ||.:|||.|||.|||...
 Worm   280 SNIKVIDMTGKQQKIYSGYDSFSMKTRSEYDTVDDEERT--------VFDVPELIHNLNLLVDLT 336

  Fly   357 EQQIIAIDNQERECSSQQAALESEHRKLEEIVQLERNHIRTLEESLERVERLIDNPDLSLPQAER 421
            |:.|...:.|......|..|||.:.:::::.:..|....:.:::..|.::....|...|:.:.:.
 Worm   337 EEGIRRSNQQLISLKDQTTALEYDLQQVQKSLGTEEQEAQHIKDVYELIDGFSSNRSPSMEECQE 401

  Fly   422 LFRELLVDYAAEFHEFGLADLAAGVIAPLLKRELVQWQPLENPTEPLPLIKKWRGMLQQGDAAEQ 486
            |||.|..::..|:..:.|..:|...:.||:::..|.|:|||:......||..||.:|   |.::.
 Worm   402 LFRRLRSEFPHEYELYSLETVAIPTVLPLIQKYFVAWKPLEDKNYGCELISTWRDIL---DDSKN 463

  Fly   487 QPRNVFD----------PYSSLIWAGVMPSFRSSAAAWQPK-EHPPMASLLDAWAPLLPSWVLDS 540
            ..:..|.          .|..:||.|::||.|.:...|.|. :...|..|::.|.|||.:|:.::
 Worm   464 GRKMTFGHNKTKGDEIRAYDRIIWEGILPSIRRACLQWDPSTQMHEMIELVEQWIPLLSAWITEN 528

  Fly   541 VLEQLVLPRLVAGVQEWDPLTDTVPIDSWVLPWHAILGSKLEEAVYPQIRSKLGIALRAWSPHDR 605
            :|||||:|::...|.:|||:||.:||..|::||..:||.:: :.|.|.||.||..||:.|.|.||
 Worm   529 ILEQLVVPKIAERVNQWDPMTDEIPIHEWLVPWLVLLGDRI-QTVMPPIRQKLSKALKLWDPMDR 592

  Fly   606 SARAMLTPWQKAFPEEEMQEFLQRYIVPKLQATLGELIINP-MHQDLELWQQVWEWHELIDPMYM 669
            ||...|.|||..:.......|:.:.|||||...|..:.:|| |:.:...|....||.|...|..:
 Worm   593 SALETLRPWQNVWSAATFSAFIAQNIVPKLGVALDTMELNPTMNPEYPEWTACMEWLEFTHPDAI 657

  Fly   670 AQLLDRHFFPRWMQVLVVWLNQSP--DYAEISRWYTGWKSMLSEPLLREPSVKEHLRRALEIMHR 732
            |.::.::||||:...|.:||: ||  ||.|:.|||..||:.:.:.|:..|:|.|:|||::..:.|
 Worm   658 ANIVTKYFFPRFYNCLCLWLD-SPGVDYNEVKRWYGSWKARIPQVLVNYPTVNENLRRSMIAIGR 721

  Fly   733 ASDTLLQ----------PTVTPTPPPPVPP-----APVIMMDLIHPPAQLEFKELVSQQCADLGI 782
            :    ||          |.....||||:.|     |||         .:|..||::.......|.
 Worm   722 S----LQGEKVGGLQATPIAPMAPPPPMAPHFTQAAPV---------QKLSLKEIIEYTAGKNGF 773

  Fly   783 IFAPLPGRREMGKQIYRVGKLFCYIDRHVCMVSDGSFSNWKPVSLNHLLERSQ 835
            .:.|...|.:.|:|::..|.|..|:|..:..|.|.....|:|..||.|::.:|
 Worm   774 TYHPQKDRYKDGRQVFWFGALSIYLDSEMVYVMDPIEFVWRPSGLNELIQMAQ 826

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sip1	NP_001285636.1	TIP_N	3..93	CDD:289242	35/99 (35%)
		G-patch	167..211	CDD:279867	26/48 (54%)
		GCFC	416..685	CDD:285127	94/280 (34%)
stip-1	NP_496226.2	TIP_N	4..104	CDD:289242	37/110 (34%)
		G-patch	154..197	CDD:279867	23/42 (55%)
		DUF1319	310..>411	CDD:284451	30/108 (28%)
		GCFC	397..673	CDD:285127	94/279 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160165212
Domainoid	1	1.000	189	1.000	Domainoid score	I1951
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H40813
Inparanoid	1	1.050	417	1.000	Inparanoid score	I1017
Isobase	1	0.950	-	0	Normalized mean entropy	S4097
OMA	1	1.010	-	-		QHG54857
OrthoDB	1	1.010	-	-		D1238995at2759
OrthoFinder	1	1.000	-	-		FOG0004443
OrthoInspector	1	1.000	-	-		oto19768
orthoMCL	1	0.900	-	-		OOG6_103393
Panther	1	1.100	-	-	LDO	PTHR23329
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1931
SonicParanoid	1	1.000	-	-		X3147
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	15	14.890