DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bon and TRIM66

DIOPT Version :9

Sequence 1:	NP_001262765.1	Gene:	bon / 44235	FlyBaseID:	FBgn0023097	Length:	1207	Species:	Drosophila melanogaster
Sequence 2:	NP_001374951.1	Gene:	TRIM66 / 9866	HGNCID:	29005	Length:	1392	Species:	Homo sapiens

Alignment Length:	1434	Identity:	323/1434 - (22%)
Similarity:	500/1434 - (34%)	Gaps:	422/1434 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 PNTASGAPTTSSLSSSSLSLSNPCDSAEKRSESNSSASAKFTLFKCVYCAQLL---GSNDRPKLL 99
            |...:|......:|...|.|:.       :.....|...:..:..|..|.|.|   ||:    ||
Human    30 PVLGTGMAVDMGMSFMGLPLAG-------QKHCPKSGQMEAMVMTCSLCHQDLPGMGSH----LL 83

  Fly   100 ECLHVACAQCVSTKFSEL-------DRSLPPLIHCPVCDNASQQEFIVDNQFLIEQCTAGDSGDG 157
            .|.|:....|......||       :.....||.||.|:.......:.::.||  .|...:
Human    84 SCQHLLRKDCFQGLIQELGQIAKAHETVADELISCPGCERVYLTRDVTEHFFL--HCVPTE---- 142

  Fly   158 VGLLGLTGEGQKSSAAASIQCSSCSDGAVATSWCVDCSEYICDSCVQAHQRLKITKDHTIKPKDE 222
                      |...|.   .||.|.:...|...|..|:.::|.||.:.|:...: ......|:.:
Human   143 ----------QPKMAR---NCSECKEKRAAHILCTYCNRWLCSSCTEEHRHSPV-PGGPFFPRAQ 193

  Fly   223 ANNEQLAGAAGVDKLHMCQLHPQEKLSLFCETCDKLTCRDCQLSDHRDHKYKFAHEIATESRQAL 287
            ..:..:.|..|...|: |.||.||.|.|||||||.|||..|.:.:|::|:.:...|:....|..|
Human   194 KGSPGVNGGPGDFTLY-CPLHTQEVLKLFCETCDMLTCHSCLVVEHKEHRCRHVEEVLQNQRMLL 257

  Fly   288 STLVSEINYKRFLLSSATKVIDDRQQLIHDKKKDLIKEITAMAVKITNTVNTRGKQLIMRLNEVC 352
            ..:.:::.:|:..|.::.|.|:||...:..:.:.:..:|....:.:.|.:|.:...||..|..:.
Human   258 EGVTTQVAHKKSSLQTSAKQIEDRIFEVKHQHRKVENQIKMAKMVLMNELNKQANGLIEELEGIT 322

  Fly   353 DSKLKVLVEKKETLQLLSDNTDHCIDFMQNALEKGSDFAILSSKKSLVRHLQKL---KCQRADIP 414
            :.:.:.|.::.:::.:|:...:|..:|:..|:...:....|.||:.:|..:|:|   .|.    .
Human   323 NERKRKLEQQLQSIMVLNRQFEHVQNFINWAVCSKTSVPFLFSKELIVFQMQRLLETSCN----T 383

  Fly   415 NPEIP--VRIQVQLNQVSDLQKVISQLGIIIVDG-----------------KPY----------- 449
            :|..|  :|...:.|..:   |.::.||.|..:|                 .|:
Human   384 DPGSPWSIRFTWEPNFWT---KQLASLGCITTEGGQMSRADAPAYGGLQGSSPFYQSHQSPVAQQ 445

  Fly   450 --------------------------PPTPSPNG-TPQPQ-HPP---RQPPS--PNMAPPLRPG- 480
                                      |.:||..| .|.|. ||.   ||||.  |.....|:..
Human   446 EALSHPSHKFQSPAVCSSSVCCSHCSPVSPSLKGQVPPPSIHPAHSFRQPPEMVPQQLGSLQCSA 510

  Fly   481 -LPPGMPAGLSPNGPPVNFGP--QNGPPLYSNAAQQQFNNLSMSRSF----PGD----------- 527
             ||.......||: ||....|  :..||:...:..|:......|:..    |.|
Human   511 LLPREKELACSPH-PPKLLQPWLETQPPVEQESTSQRLGQQLTSQPVCIVPPQDVQQGAHAQPTL 574

  Fly   528 --GSGKVRFG------------------------------GMPPVGMQRH----GQPHVSSSTH- 555
              .|.:|:||                              .:||...|.|    ...|::||.|
Human   575 QTPSIQVQFGHHQKLKLSHFQQQPQQQLPPPPPPLPHPPPPLPPPPQQPHPPLPPSQHLASSQHE 639

  Fly   556 -------PQNMDI------------SLRGLLNNQAAQSPNAHM---------------------- 579
                   .|||||            .|..||.   ||.|:..:
Human   640 SPPGPACSQNMDIMHHKFELEEMQKDLELLLQ---AQQPSLQLSQTKSPQHLQQTIVGQINYIVR 701

  Fly   580 ---------------AFNGPPSYPGG--------------PQ--GAPAPAHQPMGPQMRPHFMPG 613
                           |.:.||:..|.              ||  |...|...|.......|..|.
Human   702 QPAPVQSQSQEETLQATDEPPASQGSKPALPLDKNTAAALPQASGEETPLSVPPVDSTIQHSSPN 766

  Fly   614 Q----------QGFSQ--------------------------GGGPGGGP----RDANFMNSNAR 638
            .          .|||.                          .|.|...|    .....::|...
Human   767 VVRKHSTSLSIMGFSNTLEMELSSTRLERPLEPQIQSVSNLTAGAPQAVPSLLSAPPKMVSSLTS 831

  Fly   639 FQSQ--------------------YQRMAN-HAQQAAAAAAMAGAAGGGGGQIPSPGALQRPQMM 682
            .|:|                    :|.|.| .:....|.|::|......|..:.|......|.:.
Human   832 VQNQAMPSLTTSHLQTVPSLVHSTFQSMPNLISDSPQAMASLASDHPQAGPSLMSGHTQAVPSLA 896

  Fly   683 SNPMQN---VSAMQNSLGFHGSQAGFNTGP--PQ--TSPQLGGGGMHSLAKWHIPQSAQQSNMCS 740
            :.|:|:   ||.||...| ..|.:|..:|.  |:  ..|.|    .::|.|.....|.:.:::..
Human   897 TCPLQSIPPVSDMQPETG-SSSSSGRTSGSLCPRDGADPSL----ENALCKMESEDSTRFTDLLG 956

  Fly   741 QQGPLLPFANGRQTSENFKI--SLKSPNTLKNSTPP--SLGGGGAGHQGHGNGSSSAQLNAAALG 801
             |||::|   |....::..|  .|:.|..|....||  .:.......|.:.|..........||.
Human   957 -QGPIVP---GLDAPKDLAIPSELEEPINLSVKKPPLAPVVSTSTALQQYQNPKECENFEQGALE 1017

  Fly   802 LG----------------PAVSI--LSNVTSTNPKTP----SPSTHENTKDFTEPID-------- 836
            |.                |.|.:  |....:::.:.|    .|..::....|...|:
Human  1018 LDAKENQSIRAFNSEHKIPYVRLERLKICAASSGEMPVFKLKPQKNDQDGSFLLIIECGTESSSM 1082

  Fly   837 --KVRDDSINDLIATIAKLDSNGVQVLPEGRTKTTS-------PQVHSSTDLSNTQEVNNKNEQK 892
              ||..|.:::  ||.|.    |:    |||..|.:       |:|..::...:.........:|
Human  1083 SIKVSQDRLSE--ATQAP----GL----EGRKVTVTSLAGQRPPEVEGTSPEEHRLIPRTPGAKK 1137

  Fly   893 DDP----NEDWCAVCLDGGELMCCDKCPKVFHQNCHIPAISSLPDESESWQCLLCVNIKELTKTE 953
            ..|    |||:|||||:||||:|||:||||||.:||:||:.|.|  ...|.|.||   :.||:.|
Human  1138 GPPAPIENEDFCAVCLNGGELLCCDRCPKVFHLSCHVPALLSFP--GGEWVCTLC---RSLTQPE 1197

  Fly   954 ------------GSEKSSSGELSALELRILQRICLELYCQYEQSLNFREPESPANTSYYEIVSSP 1006
                        ...::|.| ||..:.:..:::.|.|.|. ..||.|.||.||....||:|:..|
Human  1198 MEYDCENACYNQPGMRASPG-LSMYDQKKCEKLVLSLCCN-NLSLPFHEPVSPLARHYYQIIKRP 1260

  Fly  1007 MSLDVIRTRLDPSSPNHYKDIAGFVSDVRLIFSNTYLFYQEDTKTYSNAKYLENFFEEQLAKWLP 1071
            |.|.:||.:|....|.||......||||||:|.|...|...|::.....:.||.|||..|.:..|
Human  1261 MDLSIIRRKLQKKDPAHYTTPEEVVSDVRLMFWNCAKFNYPDSEVAEAGRCLEVFFEGWLKEIYP 1325

  Fly  1072 QFEGTKPQGKRNTSNSPALLGVNAT--GSPSP--IENGRKSCGSASLGDSDGACLPAKRARRSAH 1132
            :....:|:.:.:.|...:.....:|  |.|.|  ::.|                :..||.||  |
Human  1326 EKRFAQPRQEDSDSEEVSSESGCSTPQGFPWPPYMQEG----------------IQPKRRRR--H 1372

  Fly  1133 EXNE 1136
            ..||
Human  1373 MENE 1376

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bon	NP_001262765.1	zf-RING_5	82..130	CDD:291308	17/57 (30%)
		BBOX	239..275	CDD:237988	19/35 (54%)
		BBC	284..409	CDD:128778	25/127 (20%)
		PHD_TIF1_like	899..943	CDD:277016	26/43 (60%)
		Bromo_tif1_like	963..1072	CDD:99934	40/108 (37%)
TRIM66	NP_001374951.1	Bbox1_TRIM66	149..185	CDD:380869	10/36 (28%)
		Bbox2_TRIM66-like	208..250	CDD:380852	21/42 (50%)
		BBC	253..378	CDD:128778	25/124 (20%)
		PHD_SF	1145..1193	CDD:419867	31/52 (60%)
		Bromo_tif1_like	1218..1326	CDD:99934	40/108 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	75	1.000	Domainoid score	I9077
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	344	1.000	Inparanoid score	I2326
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330513at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.970