Protein Alignment bon and Trim33

DIOPT Version :10

• Sequence 1: NP_001262765.1
• Gene: bon / 44235
• FlyBaseID: FBgn0023097
• Length: 1207
• Species: Drosophila melanogaster
• Sequence 2: NP_444400.2
• Gene: Trim33 / 94093
• MGIID: 2137357
• Length: 1140
• Species: Mus musculus
• Alignment Length: 1187
• Identity: 309/1187 - (26%)
• Similarity: 480/1187 - (40%)
• Gaps: 292/1187 - (24%)

  Fly    26 AVPTDALPQMSTPNTASG-------------APTTSSLSSSSLSLSNPCDSAEKRSESNSSASAK 77
            |||..|   .|||..|:.             ||..:..|||...|..|..
Mouse    88 AVPGGA---ASTPAPAAAPAPAPAPAPAPAPAPAPAPGSSSGPPLGPPAS--------------- 134

  Fly    78 FTLFKCVYCAQLLGS--NDRPKLLECLHVACAQCVSTKFSELDRSLP----------PLIHCPVC 130
             .|..|..|.|.|.|  ...||||.|||..|.:|:.....:|...:|          .:|.||||
Mouse   135 -LLDTCAVCQQSLQSRREAEPKLLPCLHSFCLRCLPEPERQLSVPIPGGSNGDVQQVGVIRCPVC 198

  Fly   131 DNASQQEFIVDNQFLIEQCTAGDSGDGVGLLGLTGEGQKSSAAASIQCSSCSDGAVATSWCVDCS 195
            ....:|..:|||.|:.:...|..|.|           :||...    |:||.|.|.|..:||:|.
Mouse   199 RQECRQIDLVDNYFVKDTSEAPSSSD-----------EKSEQV----CTSCEDNASAVGFCVECG 248

  Fly   196 EYICDSCVQAHQRLKITKDHTIKPKDEANNEQLAGAAGVDKLHMCQLHPQEKLSLFCETCDKLTC 260
            |::|.:|::||||:|.||||.|:.|::.:  :..|.:| .:...|.:|.||:|.|||||||:|||
Mouse   249 EWLCKTCIEAHQRVKFTKDHLIRKKEDVS--ESVGTSG-QRPVFCPVHKQEQLKLFCETCDRLTC 310

  Fly   261 RDCQLSDHRDHKYKFAHEIATESRQALSTLVSEINYKRFLLSSATKVIDDRQQLIHDKKKDLIKE 325
            |||||.:|::|:|:|..|.....:.|:..|::::..|:..:..|...:.:|.:.:::..|.:.:|
Mouse   311 RDCQLLEHKEHRYQFLEEAFQNQKGAIENLLAKLLEKKNYVHFAATQVQNRIKEVNETNKRVEQE 375

  Fly   326 ITAMAVKITNTVNTRGKQLIMRLNEVCDSKLKVLVEKKETLQLLSDNTDHCIDFMQNALEKGSDF 390
            |......:.|.:|.:||.|:.:|..|...:...|::::..:..||....|.::|...|:..||..
Mouse   376 IKVAIFTLINEINKKGKSLLQQLENVTKERQMKLLQQQNDITGLSRQVKHVMNFTNWAIASGSST 440

  Fly   391 AILSSKKSL---VRHLQKLKCQRADIPNPEIPVRIQVQLNQVSDLQKVISQLGIIIVDGKPYPP- 451
            |:|.||:.:   :||:.|.:|.    |.|.....|:...:.....:.|:: ||.::::.||.|.
Mouse   441 ALLYSKRLITFQLRHILKARCD----PVPAANGAIRFHCDPTFWAKNVVN-LGNLVIESKPAPGY 500

  Fly   452 TPS------PNGTPQPQHPPRQPPSPNMA-------------------PPLRPGLPPGMPAGLSP 491
            ||:      |.||   .|..:.|...|:|                   ..:|...||.
Mouse   501 TPNVVVGQVPPGT---NHISKTPGQINLAQLRLQHMQQQVYAQKHQQLQQMRLQQPPA------- 555

  Fly   492 NGPPVNFGPQNGPPLYSNAAQQQFNNLSMSRSFPGDGSGKVRFGGMPPVGMQRHGQPHVSSSTHP 556
               |:        |..:...||.                            .|...|.:.....|
Mouse   556 ---PI--------PTTTATTQQH----------------------------PRQAAPQMLQQQPP 581

  Fly   557 QNMDISL--RGLLNNQAAQSPNAHMAFNGPPSYPGGPQGAPAPAHQPMGPQM-RPHFMPGQQGFS 618
            :.:.:..  ||.:|..|.|:....:|.|. ...||.|:.: ||.:..|.|.: |.|..||.
Mouse   582 RLISVQTMQRGNMNCGAFQAHQMRLAQNA-ARIPGIPRHS-APQYSMMQPHLQRQHSNPGH---- 640

  Fly   619 QGGGPGGGPRDANFMNSNARFQSQYQRMANHAQQAAAAAAMAGAAGGGGGQIPSPGALQRPQMMS 683
              .||.......|.:|..                :...|.||.|  ..|...||..|::....::
Mouse   641 --AGPFPVVSAHNPINPT----------------SPTTATMANA--NRGPTSPSVTAIELIPSVT 685

  Fly   684 NPMQNVSAMQNSLGFHGSQAGFNTGPPQTSPQLGGGGMHSLAKWHI------PQSAQQSNMCSQQ 742
            || :|:.::.:.             ||......|...:.:|...:|      ||.....|.....
Mouse   686 NP-ENLPSLPDI-------------PPIQLEDAGSSSLDNLLSRYISGSHLPPQPTSTMNPSPGP 736

  Fly   743 GPLLPFANGRQTSENFKISLKSPNTLKNSTPPSLGGGGAGHQGHGNGSSSAQLNAAALGLGPAVS 807
            ..|.|.::|...|..   .::.|:|....:..|.|..|...:...:...|.|:..
Mouse   737 SALSPGSSGLSNSHT---PVRPPSTSSTGSRGSCGSSGRTAEKSAHSFKSDQVKV---------- 788

  Fly   808 ILSNVTSTNPKTPSPSTHENTKDFTEPI--DKVRD------------DSINDLIATIAKLDSNGV 858
                       ...|.|.|....|:..:  :|..|            .|:...::|...|:|. :
Mouse   789 -----------KQEPGTEEEICSFSGAVKQEKTEDGRRSACMLSSPESSLTPPLSTNLHLESE-L 841

  Fly   859 QVLP--EGRTKTTSPQVHSS---TDLSNTQEVNNK-----------------NEQKDDPNEDWCA 901
            ..|.  |...||....:..|   :.|||.  ||.|                 |.:.|||||||||
Mouse   842 DTLTGLENHVKTEPTDISESCKQSGLSNL--VNGKSPIRNLMHRSARIGGDGNSKDDDPNEDWCA 904

  Fly   902 VCLDGGELMCCDKCPKVFHQNCHIPAISSLPDESESWQCLLCVNI------KELTKTEGSEKSSS 960
            ||.:||:|:||:|||||||..||:|.:.|.|  |..|.|..|.:|      .:....:.|:|..:
Mouse   905 VCQNGGDLLCCEKCPKVFHLTCHVPTLLSFP--SGDWICTFCRDIGKPEVEYDCDNMQHSKKGKT 967

  Fly   961 GE-LSALELRILQRICLELYCQYEQSLNFREPESPANTSYYEIVSSPMSLDVIRTRLDPSSPNHY 1024
            .: ||.::.|..:|:.|.||| :|.|:.|:||...:..:||:|:..||.|..::.:|......||
Mouse   968 AQGLSPVDQRKCERLLLYLYC-HELSIEFQEPVPVSIPNYYKIIKKPMDLSTVKKKLQKKHSQHY 1031

  Fly  1025 KDIAGFVSDVRLIFSN------------TYLFYQE-----DTKTYSNAKYLENFFEEQLAKW--- 1069
            :....||:||||||.|            .|...||     |::.....|.:..:||::|::.
Mouse  1032 QIPDDFVADVRLIFKNCERFNEMMKVVQVYADTQEINLKGDSEVAKAGKAVALYFEDKLSEIYSD 1096

  Fly  1070 -----LPQFEGTKPQGK 1081
                 ||:||..:..|:
Mouse  1097 RTFTPLPEFEQDEDDGE 1113

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
bon	NP_001262765.1	RING_Ubox	<92..130	CDD:473075	15/49 (31%)
		Bbox1_TIF1	177..220	CDD:380863	22/42 (52%)
		Bbox2_TIF1_C-VI	238..278	CDD:380833	24/39 (62%)
		BBC	284..409	CDD:128778	30/127 (24%)
		Med15	486..>743	CDD:312941	48/265 (18%)
		PHD_TIF1_like	899..943	CDD:277016	25/43 (58%)
		Bromo_tif1_like	963..1072	CDD:99934	40/133 (30%)
Trim33	NP_444400.2	RING-HC_TIF1gamma	135..202	CDD:438422	22/66 (33%)
		Bbox1_TIF1g_C-VI	224..277	CDD:380905	26/67 (39%)
		Bbox2_TIF1g_C-VI	282..334	CDD:380888	26/52 (50%)
		Necessary for oligomerization. /evidence=ECO:0000250	313..415		24/101 (24%)
		BBC	333..459	CDD:128778	29/125 (23%)
		Herpes_BLLF1	<600..>753	CDD:282904	41/195 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	655..674		5/36 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	686..705		5/32 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	716..832		22/139 (16%)
		PHD_TIF1gamma	902..947	CDD:277094	26/46 (57%)
		Bromo_tif1_like	971..1096	CDD:99934	39/125 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1101..1140		5/13 (38%)