DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment bon and TRIM24

DIOPT Version :9

Sequence 1:NP_001262765.1 Gene:bon / 44235 FlyBaseID:FBgn0023097 Length:1207 Species:Drosophila melanogaster
Sequence 2:NP_056989.2 Gene:TRIM24 / 8805 HGNCID:11812 Length:1050 Species:Homo sapiens


Alignment Length:1209 Identity:313/1209 - (25%)
Similarity:484/1209 - (40%) Gaps:289/1209 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    41 ASGAPTTSSLSSSSLSLSNPCDSAEKRSESNSSASAKFTLF-KCVYCAQLLGSNDRPKLLECLHV 104
            |||.|      |::.|..|..:|.:.........:|:..|. .|..|.|.:.|. .||||.|||.
Human    19 ASGGP------SAAPSGENEAESRQGPDSERGGEAARLNLLDTCAVCHQNIQSR-APKLLPCLHS 76

  Fly   105 ACAQCVSTKFSEL--------DRSLPP--------------------LIHCPVCDNASQQEFIVD 141
            .|.:|:......|        ....||                    :|.||||.....:..|:|
Human    77 FCQRCLPAPQRYLMLPAPMLGSAETPPPVPAPGSPVSGSSPFATQVGVIRCPVCSQECAERHIID 141

  Fly   142 NQFLIEQCTAGDSGDGVGLLGLTGEGQKSSAAASIQ-CSSCSDGAVATSWCVDCSEYICDSCVQA 205
            |.|:.:                |.|...|:...|.| |:||.|.|.|..:||:|.|::|.:|::|
Human   142 NFFVKD----------------TTEVPSSTVEKSNQVCTSCEDNAEANGFCVECVEWLCKTCIRA 190

  Fly   206 HQRLKITKDHTIKPKDEANNEQLAGAAGVDKLH--MCQLHPQEKLSLFCETCDKLTCRDCQLSDH 268
            |||:|.|||||::.|:|.:.|    |.||....  .|..|.:|:|.|:||||||||||||||.:|
Human   191 HQRVKFTKDHTVRQKEEVSPE----AVGVTSQRPVFCPFHKKEQLKLYCETCDKLTCRDCQLLEH 251

  Fly   269 RDHKYKFAHEIATESRQALSTLVSEINYKRFLLSSATKVIDDRQQLIHDKKKDLIKEITAMAVKI 333
            ::|:|:|..|.....:..:.||::::..|...:......|.:|...::..:|.:.::|......:
Human   252 KEHRYQFIEEAFQNQKVIIDTLITKLMEKTKYIKFTGNQIQNRIIEVNQNQKQVEQDIKVAIFTL 316

  Fly   334 TNTVNTRGKQLIMRLNEVC-DSKLKVLVEKKETLQLLSDNTDHCIDFMQNALEKGSDFAILSSKK 397
            ...:|.:||.|:.:|..:. |.::|::.:::|... ||...:|.:.|.:.|:..||..|:|.||:
Human   317 MVEINKKGKALLHQLESLAKDHRMKLMQQQQEVAG-LSKQLEHVMHFSKWAVSSGSSTALLYSKR 380

  Fly   398 SL---VRHLQKLKCQRADIPNPEIPVRIQVQLNQVSDLQKVISQLGIIIVDGKPYPPTPSPNGTP 459
            .:   :|||.:.:|..:.:.|.    .||...:.....|.:|: ||.::::.|          ..
Human   381 LITYRLRHLLRARCDASPVTNN----TIQFHCDPSFWAQNIIN-LGSLVIEDK----------ES 430

  Fly   460 QPQHPPRQPPSPNMAPPLRPGLPPGMPAGLSPNGPPVNFGPQNGPPLYSNAAQQQFNNLSMSRSF 524
            |||.|.:.|.....:.|         |:|||.                        |.||   .|
Human   431 QPQMPKQNPVVEQNSQP---------PSGLSS------------------------NQLS---KF 459

  Fly   525 PGDGSGKVRFGGMPPVGMQRHGQPHVSSSTHPQNMDISLR----GLLNNQAAQSPNAHMAFNGPP 585
            |            ..:.:.:....|:......|...:..|    ||        ||..|  .||.
Human   460 P------------TQISLAQLRLQHMQQQVMAQRQQVQRRPAPVGL--------PNPRM--QGPI 502

  Fly   586 SYPGGPQGAPAP--------AHQPMGPQMRPH-----FMPGQQGFSQGGGPGGGPRDANFMNSNA 637
            ..|......|.|        :.:|.||.:.||     :.|.|....|...|  .|....|:...|
Human   503 QQPSISHQQPPPRLINFQNHSPKPNGPVLPPHPQQLRYPPNQNIPRQAIKP--NPLQMAFLAQQA 565

  Fly   638 RFQSQYQ------RMANHAQQAAAAAAMAGAAGGGGGQIPSPGALQRPQMMSNPMQNVSAMQNSL 696
            ..|.|..      ...|......::..:..|||..|            :...:||.::|      
Human   566 IKQWQISSGQGTPSTTNSTSSTPSSPTITSAAGYDG------------KAFGSPMIDLS------ 612

  Fly   697 GFHGSQAGFNTGPPQTSPQLGGGGMHSLAKWHIPQSAQQSNMCSQ-----QGPLLPFANGRQTSE 756
                            ||..|...:.||.......:....|:..:     .|...|.:|....|.
Human   613 ----------------SPVGGSYNLPSLPDIDCSSTIMLDNIVRKDTNIDHGQPRPPSNRTVQSP 661

  Fly   757 NFKI---SLKSPNTLKNSTPP--SLGGGGAGHQGHGNGSSSAQLNAAALGLGPAVSILSNVTSTN 816
            |..:   .|..|.|:.:..||  |......|.:| .:||||....|.:....|.| :|..:....
Human   662 NSSVPSPGLAGPVTMTSVHPPIRSPSASSVGSRG-SSGSSSKPAGADSTHKVPVV-MLEPIRIKQ 724

  Fly   817 PKTPSPSTHENTKDFTEPIDKVRDDS-------------INDLIATIAKLDSNGVQVLPEGRTKT 868
            ..:..|..:    ||...|.|...|.             :..|:...::..::...||......:
Human   725 ENSGPPENY----DFPVVIVKQESDEESRPQNANYPRSILTSLLLNSSQSSTSEETVLRSDAPDS 785

  Fly   869 TSPQVHSSTDLSNTQEVNNKNE----------------QKDDPNEDWCAVCLDGGELMCCDKCPK 917
            |..|.....|.|:    |.|:|                ::|||||||||||.:||||:||:||||
Human   786 TGDQPGLHQDNSS----NGKSEWLDPSQKSPLHVGETRKEDDPNEDWCAVCQNGGELLCCEKCPK 846

  Fly   918 VFHQNCHIPAISSLPDESESWQCLLCVNIKELTKTE-----------GSEKSSSG--ELSALELR 969
            |||.:||:|.:::.|  |..|.|..|   ::|:|.|           ..:|.:.|  :|:.::.|
Human   847 VFHLSCHVPTLTNFP--SGEWICTFC---RDLSKPEVEYDCDAPSHNSEKKKTEGLVKLTPIDKR 906

  Fly   970 ILQRICLELYCQYEQSLNFREPESPANTSYYEIVSSPMSLDVIRTRLDPSSPNHYKDIAGFVSDV 1034
            ..:|:.|.||| :|.||.|::|.......||:|:.:||.|..|:.||. ...:.|.....||:|.
Human   907 KCERLLLFLYC-HEMSLAFQDPVPLTVPDYYKIIKNPMDLSTIKKRLQ-EDYSMYSKPEDFVADF 969

  Fly  1035 RLIFSNTYLFYQEDTKTYSNAKYLENFFEEQLAKWLPQFEGTKPQGKRNTSNSPALLGVNATGSP 1099
            ||||.|...|.:.|::..:....|||:|||.|....|:....||: .||.|              
Human   970 RLIFQNCAEFNEPDSEVANAGIKLENYFEELLKNLYPEKRFPKPE-FRNES-------------- 1019

  Fly  1100 SPIENGRKSCGSASLGDSDGACLPAKRARRSAHEXNELM 1138
               |:.:.|      .|||...:..::.|..:.|..:|:
Human  1020 ---EDNKFS------DDSDDDFVQPRKKRLKSIEERQLL 1049

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
bonNP_001262765.1 zf-RING_5 82..130 CDD:291308 19/75 (25%)
BBOX 239..275 CDD:237988 22/35 (63%)
BBC 284..409 CDD:128778 29/128 (23%)
PHD_TIF1_like 899..943 CDD:277016 25/43 (58%)
Bromo_tif1_like 963..1072 CDD:99934 39/108 (36%)
TRIM24NP_056989.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 15..44 8/30 (27%)
RING-HC_TIF1alpha 53..134 CDD:319678 21/81 (26%)
RING-HC finger (C3HC4-type) 56..130 CDD:319678 19/74 (26%)
BBOX 158..194 CDD:197662 17/35 (49%)
BBOX 221..259 CDD:237988 22/37 (59%)
BBC 266..392 CDD:128778 29/126 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 429..456 11/59 (19%)
PAT1 <430..>564 CDD:330585 39/193 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 476..550 19/83 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 571..594 1/22 (5%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 643..712 18/69 (26%)
Nuclear receptor binding site (NRBS) 754..779 2/24 (8%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 766..824 10/61 (16%)
PHD_TIF1alpha 828..870 CDD:277092 25/43 (58%)
Interaction with histone H3 that is not methylated at 'Lys-4' (H3K4me0) 834..840 4/5 (80%)
Nuclear localization signal. /evidence=ECO:0000255 891..907 3/15 (20%)
Bromo_tif1_like 900..1007 CDD:99934 39/108 (36%)