Protein Alignment bon and TRIM33

DIOPT Version :10

• Sequence 1: NP_001262765.1
• Gene: bon / 44235
• FlyBaseID: FBgn0023097
• Length: 1207
• Species: Drosophila melanogaster
• Sequence 2: XP_005270993.1
• Gene: TRIM33 / 51592
• HGNCID: 16290
• Length: 1151
• Species: Homo sapiens
• Alignment Length: 1225
• Identity: 318/1225 - (25%)
• Similarity: 491/1225 - (40%)
• Gaps: 294/1225 - (24%)

  Fly    14 PLIAGIKQEQLD-----------AVPTDALPQMSTPNTASGAPTTSSLSSSSL-------SLSNP 60
            ||.|.:.:|:.:           |.|.|.    .....:||:...:|..::|:       ::|.|
Human    37 PLTAVLVEEEEEEGGRAGAEGGAAGPDDG----GVAAASSGSAQAASSPAASVGTGVAGGAVSTP 97

  Fly    61 CDSAEKRSESNSSAS-----AKFTLFKCVYCAQLLGS--NDRPKLLECLHVACAQCVSTKFSELD 118
            ..:.........||.     ....|..|..|.|.|.|  ...||||.|||..|.:|:.....:|.
Human    98 APAPASAPAPGPSAGPPPGPPASLLDTCAVCQQSLQSRREAEPKLLPCLHSFCLRCLPEPERQLS 162

  Fly   119 RSLP----------PLIHCPVCDNASQQEFIVDNQFLIEQCTAGDSGDGVGLLGLTGEGQKSSAA 173
            ..:|          .:|.||||....:|..:|||.|:.:...|..|.|           :||...
Human   163 VPIPGGSNGDIQQVGVIRCPVCRQECRQIDLVDNYFVKDTSEAPSSSD-----------EKSEQV 216

  Fly   174 ASIQCSSCSDGAVATSWCVDCSEYICDSCVQAHQRLKITKDHTIKPKDEANNEQLAGAAGVDKLH 238
                |:||.|.|.|..:||:|.|::|.:|::||||:|.||||.|:.|::.:  :..||:| .:..
Human   217 ----CTSCEDNASAVGFCVECGEWLCKTCIEAHQRVKFTKDHLIRKKEDVS--ESVGASG-QRPV 274

  Fly   239 MCQLHPQEKLSLFCETCDKLTCRDCQLSDHRDHKYKFAHEIATESRQALSTLVSEINYKRFLLSS 303
            .|.:|.||:|.|||||||:||||||||.:|::|:|:|..|.....:.|:..|::::..|:..:..
Human   275 FCPVHKQEQLKLFCETCDRLTCRDCQLLEHKEHRYQFLEEAFQNQKGAIENLLAKLLEKKNYVHF 339

  Fly   304 ATKVIDDRQQLIHDKKKDLIKEITAMAVKITNTVNTRGKQLIMRLNEVCDSKLKVLVEKKETLQL 368
            |...:.:|.:.:::..|.:.:||......:.|.:|.:||.|:.:|..|...:...|::::..:..
Human   340 AATQVQNRIKEVNETNKRVEQEIKVAIFTLINEINKKGKSLLQQLENVTKERQMKLLQQQNDITG 404

  Fly   369 LSDNTDHCIDFMQNALEKGSDFAILSSKKSL---VRHLQKLKCQRADIPNPEIPVRIQVQLNQVS 430
            ||....|.::|...|:..||..|:|.||:.:   :||:.|.:|.    |.|.....|:...:...
Human   405 LSRQVKHVMNFTNWAIASGSSTALLYSKRLITFQLRHILKARCD----PVPAANGAIRFHCDPTF 465

  Fly   431 DLQKVISQLGIIIVDGKPYPP-TPS------PNGTPQPQHPPRQPPSPNMA-------------- 474
            ..:.|:: ||.::::.||.|. ||:      |.||   .|..:.|...|:|
Human   466 WAKNVVN-LGNLVIESKPAPGYTPNVVVGQVPPGT---NHISKTPGQINLAQLRLQHMQQQVYAQ 526

  Fly   475 -----PPLRPGLPPGMPAGLSPNGPPVNFGPQNGPPLYSNAAQQQFNNLSMSRSFPGDGSGKVRF 534
                 ..:|...||.          ||        |..:...||.
Human   527 KHQQLQQMRMQQPPA----------PV--------PTTTTTTQQH-------------------- 553

  Fly   535 GGMPPVGMQRHGQPHVSSSTHPQNMDISL--RGLLNNQAAQSPNAHMAFNGPPSYPGGPQGAPAP 597
                    .|...|.:.....|:.:.:..  ||.:|..|.|:....:|.|. ...||      .|
Human   554 --------PRQAAPQMLQQQPPRLISVQTMQRGNMNCGAFQAHQMRLAQNA-ARIPG------IP 603

  Fly   598 AHQPMGPQ---MRPHFMPGQQGFSQGGGPGGGPRDANFMNSNARFQSQYQRMANHAQQAAAAAAM 659
            .|.  |||   |:||.   |:..|..|..|..|           ..|.:....|......|..|.
Human   604 RHS--GPQYSMMQPHL---QRQHSNPGHAGPFP-----------VVSVHNTTINPTSPTTATMAN 652

  Fly   660 AGAAGGGGGQIPSPGALQRPQMMSNPM---------------------------------QNV-- 689
            |..    |...||..|::....::||.                                 |||
Human   653 ANR----GPTSPSVTAIELIPSVTNPENLPSLPDIPPIQANVVPMMHSWYEFGAREKTQDQNVLE 713

  Fly   690 ----SAMQNSL-----GFHGSQAGFNTGPPQTSPQLGGGGMHSLAKWHIP------QSAQQSNMC 739
                |::.|.|     |.|......:|..|...|.....|...|:..|.|      .|......|
Human   714 DAGSSSLDNLLSRYISGSHLPPQPTSTMNPSPGPSALSPGSSGLSNSHTPVRPPSTSSTGSRGSC 778

  Fly   740 SQQGPLLPFANGRQTSENFKISLKSPNTLKNSTPP------SLGGGGAGHQGHGNGSSSAQLNAA 798
            ...|         :|:|...:|.||........|.      |..||....:......|:..|::.
Human   779 GSSG---------RTAEKTSLSFKSDQVKVKQEPGTEDEICSFSGGVKQEKTEDGRRSACMLSSP 834

  Fly   799 ALGLGPAVSILSNVTSTNPKTPSPSTHENTKDFTEPIDKVRDDSINDLIATIAKLDSNGVQVLPE 863
            ...|.|.:|...::.|......|...|..    .||.|      :|:      ....:|:..|..
Human   835 ESSLTPPLSTNLHLESELDALASLENHVK----IEPAD------MNE------SCKQSGLSSLVN 883

  Fly   864 GRTKTTSPQVHSSTDLSNTQEVNNKNEQKDDPNEDWCAVCLDGGELMCCDKCPKVFHQNCHIPAI 928
            |::...| .:|.|..:..  :.|||:   |||||||||||.:||:|:||:|||||||..||:|.:
Human   884 GKSPIRS-LMHRSARIGG--DGNNKD---DDPNEDWCAVCQNGGDLLCCEKCPKVFHLTCHVPTL 942

  Fly   929 SSLPDESESWQCLLCVNI------KELTKTEGSEKSSSGE-LSALELRILQRICLELYCQYEQSL 986
            .|.|  |..|.|..|.:|      .:....:.|:|..:.: ||.::.|..:|:.|.||| :|.|:
Human   943 LSFP--SGDWICTFCRDIGKPEVEYDCDNLQHSKKGKTAQGLSPVDQRKCERLLLYLYC-HELSI 1004

  Fly   987 NFREPESPANTSYYEIVSSPMSLDVIRTRLDPSSPNHYKDIAGFVSDVRLIFSN----------- 1040
            .|:||...:..:||:|:..||.|..::.:|......||:....||:||||||.|
Human  1005 EFQEPVPASIPNYYKIIKKPMDLSTVKKKLQKKHSQHYQIPDDFVADVRLIFKNCERFNEMMKVV 1069

  Fly  1041 -TYLFYQE-----DTKTYSNAKYLENFFEEQLAKW--------LPQFEGTKPQGK 1081
             .|...||     |::.....|.:..:||::|.:.        ||:||..:..|:
Human  1070 QVYADTQEINLKADSEVAQAGKAVALYFEDKLTEIYSDRTFAPLPEFEQEEDDGE 1124

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
bon	NP_001262765.1	RING_Ubox	<92..130	CDD:473075	15/49 (31%)
		Bbox1_TIF1	177..220	CDD:380863	22/42 (52%)
		Bbox2_TIF1_C-VI	238..278	CDD:380833	24/39 (62%)
		BBC	284..409	CDD:128778	30/127 (24%)
		Med15	486..>743	CDD:312941	58/311 (19%)
		PHD_TIF1_like	899..943	CDD:277016	25/43 (58%)
		Bromo_tif1_like	963..1072	CDD:99934	40/133 (30%)
TRIM33	XP_005270993.1	RING-HC_TIF1gamma	121..188	CDD:438422	22/66 (33%)
		Bbox1_TIF1g_C-VI	210..263	CDD:380905	26/67 (39%)
		Bbox2_TIF1g_C-VI	268..320	CDD:380888	27/52 (52%)
		BBC	319..445	CDD:128778	29/125 (23%)
		Herpes_BLLF1	<603..>764	CDD:282904	38/180 (21%)
		PHD_TIF1gamma	913..958	CDD:277094	26/46 (57%)
		Bromo_tif1_like	982..1107	CDD:99934	39/125 (31%)