DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bon and trim24

DIOPT Version :9

Sequence 1:	NP_001262765.1	Gene:	bon / 44235	FlyBaseID:	FBgn0023097	Length:	1207	Species:	Drosophila melanogaster
Sequence 2:	NP_001002870.2	Gene:	trim24 / 442869	ZFINID:	ZDB-GENE-030131-5913	Length:	961	Species:	Danio rerio

Alignment Length:	1162	Identity:	324/1162 - (27%)
Similarity:	470/1162 - (40%)	Gaps:	339/1162 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 CVYCAQLLGSNDRPKLLECLHVACAQCVSTKFSELDRSLP----PLIHCPVCDNASQQEFIVDNQ 143
            |..| :|..|:..||||.|||..|.:|:....|....:..    .:|.||||........::||.
Zfish    51 CPVC-KLSFSSREPKLLPCLHSFCKRCLPAHSSPAGTTSTAKQLSMIRCPVCQQECMDVEVLDNF 114

  Fly   144 FLIEQCTAGDSGDGVGLLGLTGEGQKSSAAASIQ-CSSCSDGAVATSWCVDCSEYICDSCVQAHQ 207
            |:         .|.|       |...|:...|.| |.||.|...|:.:||:|.|::|.:|:.|||
Zfish   115 FV---------KDSV-------EVPSSTMEKSCQLCMSCDDNTEASGFCVECVEFLCVTCIDAHQ 163

  Fly   208 RLKITKDHTIKPKDEANNEQLAGAAGVDKLHMCQLHPQEKLSLFCETCDKLTCRDCQLSDHRDHK 272
            |:|.|:|||::...|.::|  |..|...|...|.:|.||.|.|||||||:||||||||..|:||.
Zfish   164 RVKFTRDHTVRQITEMSSE--AMGASTQKPVFCDIHRQEPLKLFCETCDRLTCRDCQLLKHKDHN 226

  Fly   273 YKFAHEIATESRQALSTLVSEINYKRFLLSSATKVIDDRQQLIHDKKKDLIKEITAMAVKITNTV 337
            |:|..:.....::.|..:..::..|:..:...|..|::..|.:.:.:|.:..||......:...:
Zfish   227 YQFLEDAYRNHKEHLENMTCQLQEKKKAIEDVTNTINNGLQQVDENRKTVANEIKKSICNLIMEI 291

  Fly   338 NTRGKQLIMRLNEVCDSKLKVLVEKKETLQLLSDNTDHCIDFMQNALEKGSDFAILSSKKSL--- 399
            |.:||.|:.:|..:......:|.::::.:..||.:.||.|:|.:.|....|..|:|..|:.:
Zfish   292 NRKGKLLVNQLEAITKDHEILLKKQQQDVTSLSTHLDHVINFTKWATASNSGTALLYCKRLITCQ 356

  Fly   400 VRHLQKLKCQRADIPNPEIPVRIQVQLNQVSDLQKVISQLGIIIVDGKP--YPPTPSP------N 456
            :::|.:.||..:.:  |:..||.|.:    |........||.::|:..|  :|..|.|      |
Zfish   357 IQYLMRAKCNISYV--PQSLVRFQCR----SAFWASNVDLGSLVVEKTPVRHPSGPQPFPFQQMN 415

  Fly   457 GTP------QPQHPPRQPP-------------------SPNM---APPLR-PGLPPGMPAGLSPN 492
            ..|      |.|...||..                   |||.   .|.:| ||.||       |:
Zfish   416 PGPRAETLQQQQQQQRQSTLAQLQMQVEKLSQHNSRHHSPNQWTWYPGMRLPGPPP-------PH 473

  Fly   493 GPPVNFGPQNGPPLYSNAAQQQFNNLSMSRSFPGDGSGKVRFGGMPPVGMQRHGQPHVSSSTHPQ 557
            .|     .|.|.|               |::.|.......|:|...|..|.   ||   |:..||
Zfish   474 RP-----MQGGSP---------------SQTLPNMPHHGRRYGARSPPPML---QP---SNLPPQ 512

  Fly   558 NMDISLRGLLNNQAAQSPNAHMAFNGPPSYPGGPQGAPAPAH-QPMGPQMRPHFMPGQQGFSQGG 621
                :||||:||               |:||      |.|.. .|.|
Zfish   513 ----TLRGLINN---------------PTYP------PKPVEVLPRG------------------ 534

  Fly   622 GPGGGPRDANFMNSNARFQSQYQRMANHAQQAAAAAAMAGAAGGGGGQIPSPGALQRPQMMSNPM 686
                            ||           .||||.::        |..:|||..||:..|.:...
Zfish   535 ----------------RF-----------PQAAAYSS--------GAPLPSPNTLQQQNMQATSY 564

  Fly   687 QN----VSAMQNSLGFHGSQAGFNTGPPQTSPQLGGGGMHSLAKWHIPQSAQQSNMCSQQGPLLP 747
            .|    .||:.::           ..|..|         |:    |:....:.:
Zfish   565 LNRRCDPSALMSA-----------QRPSYT---------HT----HLSMPTETA----------- 594

  Fly   748 FANGRQTSENFKISLKSPNTLKNSTPPSLGGGGAGHQGHGNGSSSAQLNAAALGLGPAVSILSNV 812
             |.|||.|: ..::...|.|                      ||.:...|.|...||     ||.
Zfish   595 -AQGRQFSQ-MSVTSSEPKT----------------------SSVSWKRAEAPQSGP-----SNP 630

  Fly   813 TSTNPKTPSPSTHENTKDFTEPIDKVRDDSINDLIATIAKL---DSNGVQVLPEGRTKTTSPQVH 874
            ::...:..||......||..|..|:||      .:.|.||.   ||.|||      :::..|
Zfish   631 STKRRRRSSPGPVIVIKDEPEDDDEVR------FVNTSAKASLPDSTGVQ------SQSVQP--- 680

  Fly   875 SSTDLSNTQEVNNKNEQKDDPNEDWCAVCLDGGELMCCDKCPKVFHQNCHIPAISSLPDESESWQ 939
                  ..|:.....|..:||||||||||.:||||:||||||||||.:||:|.:::.|  |..|.
Zfish   681 ------GEQQSEKTPEADEDPNEDWCAVCQNGGELLCCDKCPKVFHLSCHVPTLTASP--SGEWY 737

  Fly   940 CLLC--VNIKEL---TKTEGSEKSSSGELSA-----LELRILQRICLELYCQYEQSLNFREPESP 994
            |..|  :|..|:   ....|..|....:|.:     ::.|..:|:.|.|||. |.|.:|:||.:|
Zfish   738 CTFCRDLNSPEMQYNVNAGGESKDLKQDLHSETFTHVDRRKCERLLLRLYCN-ELSTDFQEPITP 801

  Fly   995 AN-TSYYEIVSSPMSLDVIRTRLDPSSPNHYKDIAGFVSDVRLIFSNTYLFYQEDTKTYSNAKYL 1058
            :: ..|.||:.:||.|.|:|::|:.|   .||....||:||||||.|...|::|||:..|....|
Zfish   802 SSMPEYSEIIKTPMDLSVVRSKLEDS---QYKSTEDFVADVRLIFKNCATFHKEDTEMASVGANL 863

  Fly  1059 ENFFEEQLAKWLPQ--FEGTKPQG-----KRNTS---------NSPALLGVNATGSPSPIENGRK 1107
            |:||||||....|:  |.|.|.:|     ...||         .|||    ..|..| |.|:
Zfish   864 ESFFEEQLKLLYPERTFPGVKEEGIAPACPEETSPIAKTPPQDTSPA----EETARP-PAED--- 920

  Fly  1108 SCGSASLGDSDGACLPAKRARRSAHEXNE-----LMPGGKGTDGEQQAETGQERRQE 1159
                          ||.:.|  ||.: .|     ..|.|   ....:|||..:..::
Zfish   921 --------------LPQEEA--SAKDTEEKPEDISSPAG---SAPAEAETDSKESKD 958

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bon	NP_001262765.1	zf-RING_5	82..130	CDD:291308	17/50 (34%)
		BBOX	239..275	CDD:237988	24/35 (69%)
		BBC	284..409	CDD:128778	27/127 (21%)
		PHD_TIF1_like	899..943	CDD:277016	26/43 (60%)
		Bromo_tif1_like	963..1072	CDD:99934	47/114 (41%)
trim24	NP_001002870.2	zf-RING_5	51..103	CDD:291308	19/52 (37%)
		BBOX	132..176	CDD:197662	21/43 (49%)
		BBOX	192..230	CDD:237988	24/37 (65%)
		iSH2_PI3K_IA_R	237..363	CDD:304922	26/125 (21%)
		TNG2	<604..744	CDD:227367	61/189 (32%)
		PHD_SF	699..744	CDD:304600	27/46 (59%)
		Bromo_tif1_like	771..877	CDD:99934	46/109 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	69	1.000	Domainoid score	I9590
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	340	1.000	Inparanoid score	I2332
OMA	1	1.010	-	-		QHG46815
OrthoDB	1	1.010	-	-		D330513at33208
OrthoFinder	1	1.000	-	-		FOG0003753
OrthoInspector	1	1.000	-	-		otm24948
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR25462
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3741
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	9.080